5-Fluorouracil Derivatives. IV. Synthesis of Antitumor-Active Acyloxyalkyl-5-fluorouracils

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概要

• 論文の詳細を見る

• The toxicity and tumor affinity of 5-fluorouracil (1) have been modified by the introduction of acyloxyalkyl group (s) at the 1-, 3- or 1,3-position (s) of 1. 1-Acyloxyalkyl-5-fluorouracil (3), 3-acyloxyalkyl-5-fluorouracil (4) and 1,3-bis (acyloxyalkyl)-5-fluorouracil (5) were obtained by three methods : i) the reaction of α-chloroalkyl carboxylate (2) with 1,ii) the reaction of alkylidene diacylate with 2,4-bis (trimethylsilyloxy)-5-fluoropyrimidine, iii) partial hydrolysis of 5. Compounds 3,4 and 5 showed antitumor activity.

• 公益社団法人日本薬学会の論文
• 1984-02-25

著者

• 尾崎 庄一郎

  愛媛大工

• 尾崎 庄一郎

  Faculty of Engineering, Ehime University

• 森 春樹

  Research Center, Mitsui Toatsu Chemicals

• 渡辺 裕

  Faculty of Engineering, Ehime University

• 石川 勝敏

  Research Center, Mitsui Toatsu Chemicals

• 水野 晴雄

  Research Center Mitsui Toatsu Chemicals

• Miura Hirohito

  National Food Research Institute

• 星子 知範

  Faculty of Engineering, Ehime University

• 石川 勝敏

  Research Center Mitsui Toatsu Chemicals

• 星子 知範

  Eisai Tsukuba Research Laboratories

• Hoshiko Tomonori

  Faculty Of Engineering Ehime University

• Moriya H

  Department Of Pathology Gifu University School Of Medicine

• 森 春樹

  Research Center Mitsui Toatsu Chemicals

• 星子 知範

  Faculty Of Engineering Ehime University

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