A Facile Method for Synthesis of N-Acyloxymethyl-5-fluorouracils, as a Class of Antitumor Agents(Medicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
Antitumor-active derivatives of 5-fluorouracil were prepared via a new method by introducing an acyloxymethyl group at the 1-, 3-, or 1,3-position(s). These derivatives were obtained by condensing 1,3-bis(hydroxymethyl)-5-fluorouracil with various short-/long-chain carboxylic acids or their derivatives, in the presence of dicyclohexylcarbodiimide and a catalytic amount of N,N-dimethylaminopyridine. Some of the derivatives showed strong antitumor activity against the leukemia L1210 system when administered orally.
- 社団法人日本薬学会の論文
- 1987-10-25
著者
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星 昭夫
National Cancer Center Research Institute
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飯郷 正明
National Cancer Center Research Institute
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尾崎 庄一郎
愛媛大工
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尾崎 庄一郎
Faculty of Engineering, Ehime University
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AHMAD SUHAIL
Faculty of Engineering, Ehime University
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長瀬 敏雄
Faculty of Engineering, Ehime University
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徳善 令子
National Cancer Center Research Institute
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Ahmad Suhail
Faculty Of Engineering Ehime University
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Ahmad Suhail
愛媛大学 工
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Iigo M
National Cancer Center Research Institute
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長瀬 敏雄
愛媛大学 工
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