5-Fluorouracil Derivatives. XXII. Synthesis and Antitumor Activities of 1-Carbamoyl-5-fluorouracils

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概要

• 論文の詳細を見る

• Fifty-four 1-carbamoyl-5-fluorouracils were synthesized from 5-fluorouracil and isocyanate or amine. Antitumor activity was tested in the L-1210 tumor system, and 11 compounds gave better values of therapeutic ratio than HCFU (1-hyxylcarbamoyl-5-fluorouracil). 1-(4-Methoxycyclohexylcarbamoyl)-5-fluorouracil gave the best result.

• 社団法人日本薬学会の論文
• 1997-08-15

著者

• Hoshi Akio

  国立がんセンター

• Hoshi Akio

  National Cancer Center Research Institute

• HOSHIKO TOMONORI

  Faculty of Engineering, Ehime University

• IIGO MASAAKI

  National Cancer Center Research Institute

• Hoshi A

  National Cancer Center Resarch Institute

• Iigo Masaaki

  National Cancer Center Resarch Institute

• Watanabe Y

  Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U

• OZAKI Shoichiro

  Department of Chemistry, Shandong University

• KONG Xiangzheng

  Department of Chemistry, Shandong University

• WATANABE Yutaka

  Faculty of Engineering, Ehime University

• KOGA Toshikazu

  Faculty of Engineering, Ehime University

• OGASAWARA Tomio

  Faculty of Engineering, Ehime University

• TAKIZAWA Tsuneharu

  Faculty of Engineering, Ehime University

• FUJISAWA Hiroshi

  Faculty of Engineering, Ehime University

• 星子 知範

  Faculty of Engineering, Ehime University

• 星子 知範

  Eisai Tsukuba Research Laboratories

• Hoshiko Tomonori

  Faculty Of Engineering Ehime University

• Watanabe Yoshifumi

  Department Of Biomolecular Engineering Tokyo Institute Of Technology

• Ozaki S

  Faculty Of Pharmaceutical Sciences Osaka University

• Koga Toshikazu

  Faculty Of Engineering Ehime University

• Ozaki Shoichiro

  Department Of Applied Chemistry Faculty Of Engineering Ehime University

• Ogasawara T

  Faculty Of Engineering Ehime University

• Fujisawa H

  Faculty Of Engineering Ehime University

• Kong Xiangzheng

  Department Of Chemistry Shandong University

• Takizawa T

  Faculty Of Engineering Ehime University

• Watanabe Yutaka

  Faculty Of Agriculture Hokkaido University

• HOSHI Akio

  National Cancer Center Resarch Institute

• Watanabe Yoshihiko

  Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University

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