BIOLOGICAL ACTIVITY OF VITAMIN D_3 DERIVATIVES IN INDUCING DIFFERENTIATION OF HL-60 HUMAN PROMYELOCYTIC LEUKEMIA CELLS
スポンサーリンク
概要
- 論文の詳細を見る
Induction of cell differentiation by twenty-one derivatives of vitamin D_3 and their binding affinity for the receptor of 1α, 25-dihydroxyvitamin D_3 an active vitamin D_3 metabolite, were examind using HL-60 human promyelocytic leukemia cells and chick intestinal cytosol, respectively. 1α, 24(R)-dihydroxy-26-chlorovitamin D_3 is found to be more active than 1α, 24(R)-dihydroxyvitamin D_3 and 1α, 25-dihydroxyvitamin D_3 in the two abilities to induce the differeniation and to bind to the receptor. the results suggest that a hydroxy group at C-1 position of vitamin D_3 and a hydroxy or oxo group at C-25 or C-24 position are essential for both abilities. In diastereoisomers of 1α, 25-dihydroxyvitamin D_3-26,23-lactone, synthesized (23S, 25S)1α, 25-dihydroxyvitamin D_3-26,23-lactone was more active in both abilities than the natural metabolite, (23S, 25R)1α, 25-dihydroxy-vitamin D_3-26,23-latone, which shows anti-vitamin D action.
- 社団法人日本薬学会の論文
著者
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Hoshi Akio
National Cancer Center Research Institute
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Hoshi A
National Cancer Center Research Inst. Tokyo
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YOSHIDA MITSUZI
National Cancer Center Research Institute
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ISHIZUKA SEIICHI
Teijin Institute for Bio-Medical Research
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