DISTRIBUTION OF 1-HEXYLCARBAMOYL-5-FLUOROURACIL AND 5-FLUOROURACIL BY ORAL ADMINISTRATION IN MICE
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概要
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The distribution of 1-hexylcarbamoyl-5-fluorouracil-6-^<14>C (HCFU) and 5-fluorouracil-6-^<14>C (5FU) was studied in mice following a single oral administration. When HCFU and 5FU were given orally to mice, they were readily absorbed from the gastrointestinal tract and the radioactivity was detected in various tissues and organs. Highest radioactivity after administration of HCFU was shown in the liver, kidneys, stomach wall and plasma, followed by the lungs, and adrenals. On the other hand, highest radioactivity after administration of 5FU was exhibited in the liver, myocardium, lungs, pancreas, spleen, kidneys, adrenals and gastro-intestinal wall. Distribution pattern and disppearance of HCFU were similar to those of 5FU. Marked difference in the distribution between HCFU and 5FU was detected only in the gastro-intestinal wall, namely, HCFU was retained for a long period in the stomach wall while 5FU did in the intestinal wall.
- 公益社団法人日本薬学会の論文
著者
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Hoshi Akio
Pharmacology Division National Cancer Center Research Institute
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Hoshi Akio
National Cancer Center Research Institute
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Hoshi A
National Cancer Center Resarch Institute
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Iigo Masaaki
Pharmacology Division National Cancer Center Research Institute
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Kuretani Kazuo
Pharmacology Division National Cancer Center Research Institute
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Hoshi Akio
Pharmaceutical Development Laboratories Meiji Seika Kaisha Ltd. : Central Research Laboratories Meij
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Ishiguro Masaji
Loboratory Of Chemistry For Natural Products Tokyo Institute Of Technology
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NAKAMURA ASAKO
Pharmacology Division, National Cancer Center Research Institute
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Nakamura Asako
Pharmacology Division National Cancer Center Research Institute
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