ANTITUMOR ACTIVITY OF 1-ALKOXYCARBONYLALKYLCAR-BAMOYL-5-FLUOROURACIL DERIVATIVES BY ORAL ADMINISTRATION
スポンサーリンク
概要
- 論文の詳細を見る
Antitumor activity of seven 5-fluorouracil derivatives having carbamoyl linkage with amino acid was examined against L-1210 leukemia, adenocarcinoma 755,ascites sarcoma 180,Ehrlich ascites carcinoma and Lewis lung carcinoma by oral administration. These compounds showed more than 30% increase in life-span (ILS) against L-1210 at optimal doses when given by oral administration. Therapeutic ratios (ILS_<max>/ILS_<30>) of 1-methoxycarbonylmethylcarbamoyl and 1-(1-ethoxycarbonyl-3-methylthiopropylcarbamoyl) derivatives of 5-fluorouracil in L-1210 system were 4.8 and 4.7,respectively. 1-Methoxycarbonylmethylcarbamoyl and 1-(2-ethoxycarbonylethylcarbamoyl) derivatives of 5-fluorouracil inhibited completely the growth of adenocarcinoma 755 when given orally, but only 1-methoxycarbonylmethylcarbamoyl derivative inhibited 99 and 98% of the growth of ascites sarcoma 180 and Ehrlich ascites carcinoma, respectively. The latter compound increased the life-span to 48% at optimal dose in Lewis lung carcinoma system.
- 社団法人日本薬学会の論文
著者
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INOMATA Motoko
Pharmacology Division, National Cancer Center Research Institute
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Hoshi Akio
Pharmacology Division National Cancer Center Research Institute
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Hoshi Akio
国立がんセンター
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Inomata Motoko
Pharmacology Division National Cancer Center Research Institute
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Inomata Motoko
National Cancer Center Research Institute
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Hoshi A
National Cancer Center Resarch Institute
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Iigo M
National Cancer Res. Inst. Tokyo
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Iigo Masaaki
Cancer Prevention Basic Res. Project National Cancer Center Res. Inst.
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Iigo Masaaki
Pharmacology Division National Cancer Center Research Institute
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Iigo Masaaki
Experimental Pathology And Chemotherapy Division National Cancer Center Research Institute
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Kuretani Kazuo
Pharmacology Division National Cancer Center Research Institute
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ANDO NAOKO
Pharmacology Division, National Cancer Center Research Institute
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Hoshi Akio
Pharmaceutical Development Laboratories Meiji Seika Kaisha Ltd. : Central Research Laboratories Meij
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Ando Naoko
Pharmacology Division National Cancer Center Research Institute
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Ishiguro Masaji
Loboratory Of Chemistry For Natural Products Tokyo Institute Of Technology
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