IMPROVEMENT OF THERAPEUTIC EFFECT OF 5-FLUOROURACIL BY OROTIC ACID
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概要
- 論文の詳細を見る
Therapeutic effect of FU was improved by the combination with orotic acid. This combination exhibited a marked schedule dependency. The most suitable schedule was to give orally 30 mg/kg/day of orotic acid 30 minutes before FU administration. In combination of FU and orotic acid in this schedule, ILS_<30> was decreased to 2.1 from 3.1 mg/kg/day and the optimal dose was increased to 30 from 20 mg/kg/day. Maximum ILS was also increased to 81 from 54% and the therapeutic ratio was improved to 14 from 5.1.
- 公益社団法人日本薬学会の論文
著者
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Kanzawa Fumihiko
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
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Kanzawa Fumihiko
Pharmacology Division National Cancer Center Research Institute
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Hoshi Akio
Pharmacology Division National Cancer Center Research Institute
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Hoshi A
National Cancer Center Resarch Institute
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Kuretani Kazuo
Pharmacology Division National Cancer Center Research Institute
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Hoshi Akio
Pharmaceutical Development Laboratories Meiji Seika Kaisha Ltd. : Central Research Laboratories Meij
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