ANTITUMOR ACTIVITY OF QUINOCARMYCIN AGAINST CARCINOMA OF THE LUNG IN HUMAN TUMOR CLONOGENIC ASSAY
スポンサーリンク
概要
- 論文の詳細を見る
Quinocarmycin monocitrate is a novel antitumor antibiotic isolated from Streptomyces melanovinaceus. We have utilized a human tumor clonogenic assay to test the antitumor activity of this drug against carcinoma of the lung and to compare its activity with those of mitomycin C or cisplatin, which are components of the clinically effective regimens in therapy for this desease. The overall in vitro response rate (defined as less than 50% survival of tumor colony forming units) for quinocarmycin at 0.1 and 1.0 μg/ml continuous exposure was 42% and 72%, respectively, which was superior to that of other drugs. Quinocarmycin and other antitumor drugs do not have identical spectra of antitumor activities in vitro, suggesting that this compound with good in vitro activity should be further developed for clinical trials.
- 公益社団法人日本薬学会の論文
著者
-
Saijo N
Division Of Internal Medicine National Cancer Center Hospital East
-
Saijo Nagahiro
国立医薬品食品衛生研究所
-
Saijo N
Medical Oncology National Cancer Center Hospital
-
Saijo Nagahiro
Pharmacology Division, National Cancer Center Research Institute
-
Kanzawa Fumihiko
国立がんセンター
-
Kanzawa Fumihiko
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
-
Fukuoka K
National Cancer Center Res. Inst.
-
Terada Masaaki
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
-
Saijo Nagahiro
Pharmacology Division National Cancer Center Research Institute
-
Tsuchiya R
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
-
CHIANG CHIDER
Pharmacology
-
KANAZAWA FUMIHIKO
Pharmacology
-
MATSUSHIMA YUKA
Pharmacology
-
NAKANO HIDEHIKO
Pharmacology
-
NAKAGAWA KAZUHIKO
Pharmacology
-
TAKAHASHI HIDENOBU
Pharmacology
-
MORINAGA SHOJIRO
Pharmacology
-
TSUCHIYA RYOSUKE
Pharmacology
-
SASAKI YASUTSUNA
Pharmacology
-
Nakagawa Kazuhiko
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
-
Sasaki Y
Mitsubishi Kasei Corporation Research Center:school Of Pharmaceutical Sciences Kitasato University
-
Takahashi H
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
-
Chiang Chider
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
-
Nakano H
Department Of Applied Chemistry Himeji Institute Of Technology
-
Morinaga Shojiro
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
-
Matsushima Y
Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen
関連論文
- Genetic Variations and Haplotypes of ABCC2 Encoding MRP2 in a Japanese Population
- Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences
- Twelve Novel Single Nucleotide Polymorphisms in the CES2 Gene Encoding Human Carboxylesterase 2 (hCE-2)
- 日本人におけるGSTT1及びGSTM1の遺伝子多型の同定及びハプロタイプ構造の解析
- Twenty Novel Genetic Variations and Haplotype Structures of the DCK Gene Encoding Human Deoxycytidine Kinase (dCK)
- Genetic Variations of VDR/NR1I1 Encoding Vitamin D Receptor in a Japanese Population
- Genetic Variations and Frequencies of Major Haplotypes in SLCO1B1 Encoding the Transporter OATP1B1 in Japanese Subjects : SLCO1B1^*17 is More Prevalent Than ^*15
- Fourteen Novel Genetic Variations and Haplotype Structures of the TYMS Gene Encoding Human Thymidylate Synthase (TS)
- 日本人におけるヒトSLC29A1の新規遺伝子多型の同定
- Genetic Variation and Haplotype Structure of the ABC Transporter Gene ABCG2 in a Japanese Population
- Genetic Variations and Haplotypes of UGT1A4 in a Japanese Population
- Genetic Polymorphisms of UGT1A6 in a Japanese Population
- Genetic Variations of the AHR Gene Encoding Aryl Hydrocarbon Receptor in a Japanese Population
- Three Novel Single Nucleotide Polymorphisms in UGT1A9
- Novel Genetic Polymorphisms in the NR3C1 (Glucocorticoid receptor) Gene in a Japanese Population
- Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR113 (CAR) Gene in a Japanese Population
- Eight Novel Single Nucleotide Polymorphisms in ABCG2/BCRP in Japanese Cancer Patients Administered Irinotacan
- Three novel single nucleotide polymorphisms in UGT1A10
- A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with breast cancer
- Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway
- Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib ("Iressa")-sensitive and resistant xenograft models
- Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo
- Reversal of Cisplatin Resistance by the 1,4-Benzothiazepine Derivative, JTV-519
- CPT-11 Alters the Circadian Rhythm of Dihydropyrimidine Dehydrogenase mRNA in Mouse Liver
- Enhancement of Cisplatin Sensitivity in High Mobility Group 2 cDNA-transfected Human Lung Cancer Cells
- Characterization of a Human Small-cell Lung Cancer Cell Line Resistant to a New Water-soluble Camptothecin Derivative, DX-8951f
- Preferential Binding of E7010 to Murine β3-Tubulin and Decreased β3-Tubulin in E7010-resistant Cell Lines
- In vitro Enhancement of Antitumor Activity of a Water-soluble Duocarmycin Derivative, KW-2189, by Caffeine-mediated DNA-repair Inhibition in Human Lung Cancer Cells
- p16^ Expression Is Associated with the Increased Sensitivity of Human Non-small Cell Lung Cancer Cells to DNA Topoisomerase I Inhibitors
- Interferon-γ-inducing Factor Gene Transfection into Lewis Lung Carcinoma Cells Reduces Tumorigenicity in vivo
- Effect of Glutathione Depletion on Cisplatin Resistance in Cancer Cells Transfected with the γ-Glutamylcysteine Synthetase Gene
- A Topoisomerase II Inhibitor, NK109, Induces DNA Single- and Double-strand Breaks and Apoptosis
- Effect of suramin on cdc2 kinase activity of the purified enzyme and from the crude extracts from lung cancer cells
- Correlation of Gene-specific Damage with Cisplatin between Human Adenocarcinoma Cells and Peripheral Blood Mononuclear Cells Analyzed by Polymerase Chain Reaction-stop Assay
- A Limited Sampling Model for Estimating Pharmacokinetics of CPT-11 and Its Metabolite SN-38
- Enhancement of in vivo Antitumor Activity of a Novel Antimitotic 1-Phenylpropenone Derivative, AM-132, by Tumor Necrosis Factor-α or Interleukin-6
- Intracellular Carboxyl Esterase Activity Is a Determinant of Cellular Sensitivity to the Antineoplastic Agent KW-2189 in Cell Lines Resistant to Cisplatin and CPT-11
- EFFECTS OF PINACIDIL ON RENAL HEMODYNAMICS AND FUNCTION IN ANESTHETIZED DOGS
- EFFECTS OF TINORIDINE ON LIPID PEROXIDATION AND RENIN RELEASE IN THE RAT RENIN GRANULE FRACTION
- EFFECTS OF ALPHA-ADRENOCEPTOR AGONISTS ON RENIN RELEASE FROM RAT KIDNEY CORTICAL SLICES
- ANTITUMOR ACTIVITY OF 1-ACYLOXYMETHYL DERIVATIVES OF 5-FLUOROURACIL AGAINST L1210 LEUKEMIA
- ISOLATION AND CHARACTERIZATION OF THE MURINE LYMPHOMA L5178Y CELL LINE HIGHLY RESISTANT TO 5-FLUOROURACIL
- ANTITUMOR ACTIVITY OF ALKYLESTERS OF 5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE (FDUMP) AGAINST MURINE LYMPHOMA L5178Y RESISTANT TO 5-FLUORO-2'-DEOXYURIDINE
- Immunotherapy by intra-peritoneal intra-peritoneal injection of interleukin-2 gene transduced ling cancer cell line.
- IMPROVEMENT OF THERAPEUTIC EFFECT OF 5-FLUOROURACIL BY OROTIC ACID
- Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients
- What is the most informative pharmacodynamic model for paclitaxel (T)? : a 3 hour-infusion vs. 24-hour infusion.
- Problems with Registration-Directed Clinical Trials for Lung Cancer in Japan
- Phase I study of cisplatin, vinorelbine, and concurrent thoracic radiotherapy for unresectable stage III non-small cell lung cancer
- Tumor response to chemotherapy : The validity and reproducibility of RECIST guidelines in NSCLC patients
- INHIBITORY EFFECTS OF REPEATED INTRAVENOUS INJECTIONS OF DEXAMETHASONE ON PULMONARY TOXICITY OF A NEW MITOMYCIN C ANALOGUE, KW-2149, IN A NOVEL RAT MODEL
- Inhibitory effects of dexamethasone on pulmonary toxicity of a new mitomycin C analogue KW-2149 in a novel rat model.
- Prospective Evaluation of the Feasibility of Cisplatin-based Chemotherapy for Elderly Lung Cancer Patients with Normal Organ Functions
- ANTITUMOR ACTIVITY OF QUINOCARMYCIN AGAINST CARCINOMA OF THE LUNG IN HUMAN TUMOR CLONOGENIC ASSAY
- Enhanced Anti-tumor Effect of Trastuzumab in Combination with Cisplatin
- Long-term follow-up of patients with unresectable locally advanced non-small cell lung cancer treated with chemoradiotherapy: A retrospective analysis of the data from the Japan Clinical Oncology Group trials (JCOG0003A)
- Phase I Study of Paclitaxel by Three-hour Infusion : Hypotension Just after Infusion Is One of the Major Dose-limiting Toxicities
- Prediction of Octanol : Water Partition Coefficients Using Parameters Derived from Molecular Structures
- COMPARATIVE STUDIES OF PULSE AND CONTINUOUS EXPOSURE IN HUMAN TUMOR CLONOGENIC ASSAY
- THE USE OF HUMAN TUMOR CLONOGENIC ASSAY IN PREDICTING COMBINATION EFFECT OF CISPLATIN PLUS VINDESINE IN CARCINOMA OF THE LUNG
- STUDY OF PROTEIN KINASE INHIBITORS WITH ANTIHYPERTENSIVE ACTIVITY
- RELATIONSHIP BETWEEN ENKEPHALINASE INHIBITION OF THIORPHAN IN VIVO AND ITS ANALGESIC ACTIVITY
- Genetic Polymorphisms of Copper- and Platinum Drug-efflux Transporters ATP7A and ATP7B in Japanese Cancer Patients
- Translational and clinical studies of target-based cancer therapy
- A Computational Model for Quantitative Analysis of Cell Cycle Arrest and Its Contribution to Overall Growth Inhibition by Anticancer Agents
- IN VITRO CHEMOSENSITIVITY PATTERNS OF CARCINOMA OF THE LUNG IN HUMAN TUMOR CLONOGENIC ASSAY
- 384 Development of Resistance to Anticancer Drugs in NIH3T3 Cells Transfected with c-myc and/or c-H-ras Genes.
- A Pharmacokinetic and Pharmacodynamic Analysis of CPT-11 and Its Active Metabolite SN-38
- Pierisin-1 from cabbage butterfly suppresses HeLa tumor growth in nude mice
- Genetic Polymorphisms of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis
- Electrochemistry of 2'-Anthraquinone-modified Oligonucleotide Immobilized on Gold Surface : Differential Electron Transfer Efficiency between Single and Double Helical Forms
- Cyclic Voltammetric Responses in Hybrid Formation of 2'-Anthraquinone-Modified Oligonucleotide with DNA
- Homopyrimidine Oligonucleotides Modified by Pyrenylmethyl Group at the Terminal Position: Enhanced Fluorescence upon Binding to Double Helical DNA