IN VITRO CHEMOSENSITIVITY PATTERNS OF CARCINOMA OF THE LUNG IN HUMAN TUMOR CLONOGENIC ASSAY

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概要

• 論文の詳細を見る

• One hundred and sixty-eight different specimens of human carcinoma of the lung were tested for in vitro drug sensitivity using the human tumor clonogenic assay (HTCA) originally described by Hamburger and Salmon. One hundred and twenty-two (73%) specimens grew adequately for chemosensitivity testing. Most tumors were resistant to chemotherapeutic drugs, but in vitro sensitivity, regardless of the type of drugs, varied markedly from specimen to specimen. Although response rates to individual drugs ranged between 9% and 23%, half the specimens tested were sensitive in vitro to at least one drug. A higher in vitro sensitivity rate was observed in small cell lung carcinoma (31%) than in non-small cell lung carcinoma (17%). The frequency of in vitro sensitivity was greater for patients who had received no prior chemotherapy than those who were in relapse. These in vitro results are similar to current clinical experience. There was a significant association between in vitro sensitivity of cells from a primary tumor as compared to its metastases. Overall HTCA appears to be useful in selecting appropriate chemotherapy for individual patients with carcinoma of the lung.

• 公益社団法人日本薬学会の論文

著者

• Saijo N

  Division Of Internal Medicine National Cancer Center Hospital East

• Saijo Nagahiro

  国立医薬品食品衛生研究所

• Saijo N

  Medical Oncology National Cancer Center Hospital

• Yoshida Shigeaki

  国立がんセンター東病院 消化管内科

• Kanzawa Fumihiko

  国立がんセンター

• Kanzawa Fumihiko

  Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen

• Kanzawa Fumihiko

  Pharmacology Division National Cancer Center Research Institute

• Fukuoka K

  National Cancer Center Res. Inst.

• Eguchi Kenji

  Department Of Medical Oncology National Cancer Center Hospital

• Shinkai Tetsu

  Department Of Medical Oncology National Cancer Center Hospital

• MATSUSHIMA YUKA

  Pharmacology

• ISHIHARA JUNICHI

  Pharmacology Division, National Cancer Center Research Institute

• Shimizu E

  Osaka City Univ. Osaka‐shi Jpn

• Miyazawa Naoto

  Surgery Division National Cancer Center Hospital

• Ishihara J

  Epidemiology And Prevention Division Research Center For Cancer Prevention And Screening National Ca

• SHIMIZU EIJI

  Internal Medicine National Cancer Center Hospital

• SASAKI YASUTSUNA

  Internal Medicine National Cancer Center Hospital

• EGUCHI KENJI

  Internal Medicine National Cancer Center Hospital

• SHINKAI TETSU

  Internal Medicine National Cancer Center Hospital

• SAIJO NAGAHIRO

  Internal Medicine National Cancer Center Hospital

• HAMBURGER ANNE

  University of Maryland Cancer Center

• Matsushima Y

  Pharmacology:pathology Division National Cancer Center Research Institute:surgery Division:departmen

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