Translational and clinical studies of target-based cancer therapy

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概要

• 論文の詳細を見る
• 2003-08-01

著者

• Kaniwa N

  Department Of Genome Biology Kinki University School Of Medicine

• Tamura T

  Division Of Internal Medicine National Cancer Center Hospital

• Saijo N

  Division Of Internal Medicine National Cancer Center Hospital East

• Saijo Nagahiro

  国立医薬品食品衛生研究所

• Saijo N

  Medical Oncology National Cancer Center Hospital

• SAIJO Nagahiro

  National Cancer Center Hospital East

• Tamura Tomohide

  国立がんセンター中央病院 腫瘍内科

• Tamura T

  National Cancer Center Hospital Tokyo

• Tamura Tomohide

  Medical Oncology Division National Cancer Center Hospital

• NISHIO Kazuto

  Department of Genome Biology, Kinki University School of Medicine

• Nishio K

  Department Of Genome Biology Kinki University School Of Medicine

• Tagawa Toshiaki

  国立がんセンター中央病院 消化器内科

• Kuzuya Nobuaki

  国立医薬食品衛生研究所 薬物応答予測プロジェクト

• TAMURA Tomohide

  National Cancer Center Hospital

• Nishio Kazuto

  National Cancer Center

• Saijo Nagahiro

  Department Of Internal Medicine National Cancer Center Hospital

• Saijo Nagahiro

  National Cancer Center

• Tamura Tomohide

  Division Of Internal Medicine National Cancer Center Hospital

• Tamura Tomohide

  National Cancer Center

• NAKATA Kotoko

  National Institute of Health Sciences

• Katori N

  National Cancer Center

関連論文

• Genetic Variations and Haplotypes of ABCC2 Encoding MRP2 in a Japanese Population
• Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences
• Genetic Variations of the ABC Transporter Gene ABCB11 Encoding the Human Bile Salt Export Pump (BSEP) in a Japanese Population
• LACK OF MODIFYING EFFECTS OF EUGENOL ON DEVELOPMENT OF LUNG PROLIFERATIVE LESIONS INDUCED BY URETHANE IN TRANS-GENIC MICE CARRYING THE HUMAN PROTOTYPE c-Ha-ras GENE
• Difference in the Types of Uterine Tumors between Heterozygous p53-deficient and Wild Type CBA Mice Treated with Ethinylestradiol after N-ethyl-N-nitrosourea Initiation
• Twelve Novel Single Nucleotide Polymorphisms in the CES2 Gene Encoding Human Carboxylesterase 2 (hCE-2)
• 日本人におけるGSTT1及びGSTM1の遺伝子多型の同定及びハプロタイプ構造の解析
• Twenty Novel Genetic Variations and Haplotype Structures of the DCK Gene Encoding Human Deoxycytidine Kinase (dCK)
• Genetic Variations of VDR/NR1I1 Encoding Vitamin D Receptor in a Japanese Population
• Genetic Variations and Frequencies of Major Haplotypes in SLCO1B1 Encoding the Transporter OATP1B1 in Japanese Subjects : SLCO1B1^*17 is More Prevalent Than ^*15
• Genetic Variations and Haplotype Structures of the ABC Transporter Gene ABCC1 in a Japanese Population
• Fourteen Novel Genetic Variations and Haplotype Structures of the TYMS Gene Encoding Human Thymidylate Synthase (TS)
• 日本人における Denaturing HPLC を用いた Thiopurine S-Methyltransferase 遺伝子の新規SNPスクリーニング
• 日本人におけるヒトSLC29A1の新規遺伝子多型の同定
• Genetic Variation and Haplotype Structure of the ABC Transporter Gene ABCG2 in a Japanese Population
• Genetic Variations and Haplotypes of UGT1A4 in a Japanese Population
• Genetic Polymorphisms of UGT1A6 in a Japanese Population
• Single Nucleotide Polymorphisms and Haplotypes of CYP1A2 in a Japanese Population
• Genetic Variations of the AHR Gene Encoding Aryl Hydrocarbon Receptor in a Japanese Population
• Non-synonymous Single Nucleotide Alterations Found in the CYP2C8 Gene Result in Reduced in Vitro Paclitaxel Metabolism
• Expression of CYP2A6 in Tumor Cells Augments Cellular Sensitivity to Tegafur
• Phase I pharmacokinetic and pharmacogenomic study of E7070 administered once every 21 days
• Three Novel Single Nucleotide Polymorphisms in UGT1A9
• Novel Genetic Polymorphisms in the NR3C1 (Glucocorticoid receptor) Gene in a Japanese Population
• Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR113 (CAR) Gene in a Japanese Population
• Eight Novel Single Nucleotide Polymorphisms in ABCG2/BCRP in Japanese Cancer Patients Administered Irinotacan
• Three novel single nucleotide polymorphisms in UGT1A10
• Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples
• Antibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptor
• Synergistic interactions between the synthetic retinoid tamibarotene and glucocorticoids in human myeloma cells
• A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with breast cancer
• Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway
• Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib ("Iressa")-sensitive and resistant xenograft models
• Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo
• Reversal of Cisplatin Resistance by the 1,4-Benzothiazepine Derivative, JTV-519
• CPT-11 Alters the Circadian Rhythm of Dihydropyrimidine Dehydrogenase mRNA in Mouse Liver
• Enhancement of Cisplatin Sensitivity in High Mobility Group 2 cDNA-transfected Human Lung Cancer Cells
• Characterization of a Human Small-cell Lung Cancer Cell Line Resistant to a New Water-soluble Camptothecin Derivative, DX-8951f
• Preferential Binding of E7010 to Murine β3-Tubulin and Decreased β3-Tubulin in E7010-resistant Cell Lines
• In vitro Enhancement of Antitumor Activity of a Water-soluble Duocarmycin Derivative, KW-2189, by Caffeine-mediated DNA-repair Inhibition in Human Lung Cancer Cells
• p16^ Expression Is Associated with the Increased Sensitivity of Human Non-small Cell Lung Cancer Cells to DNA Topoisomerase I Inhibitors
• Interferon-γ-inducing Factor Gene Transfection into Lewis Lung Carcinoma Cells Reduces Tumorigenicity in vivo
• Effect of Glutathione Depletion on Cisplatin Resistance in Cancer Cells Transfected with the γ-Glutamylcysteine Synthetase Gene
• A Topoisomerase II Inhibitor, NK109, Induces DNA Single- and Double-strand Breaks and Apoptosis
• Effect of suramin on cdc2 kinase activity of the purified enzyme and from the crude extracts from lung cancer cells
• Correlation of Gene-specific Damage with Cisplatin between Human Adenocarcinoma Cells and Peripheral Blood Mononuclear Cells Analyzed by Polymerase Chain Reaction-stop Assay
• Development and characterization of an antibody specifically recognizing a mutant EGFR (L858R) protein expressed frequently in non-small cell lung cancer
• High sensitivity detection of epidermal growth factor receptor mutations in the pleural effusion of non-small cell lung cancer patients
• A Limited Sampling Model for Estimating Pharmacokinetics of CPT-11 and Its Metabolite SN-38
• Safety and pharmacokinetics of panitumumab in Japanese patients with advanced solid tumors
• 日本人におけるABCC3遺伝子の多型解析
• Enhancement of in vivo Antitumor Activity of a Novel Antimitotic 1-Phenylpropenone Derivative, AM-132, by Tumor Necrosis Factor-α or Interleukin-6
• Intracellular Carboxyl Esterase Activity Is a Determinant of Cellular Sensitivity to the Antineoplastic Agent KW-2189 in Cell Lines Resistant to Cisplatin and CPT-11
• The role of a common TNNT2 polymorphism in cardiac hypertrophy
• Summary of the ASCO-JSCO Joint Symposium
• Immunotherapy by intra-peritoneal intra-peritoneal injection of interleukin-2 gene transduced ling cancer cell line.
• Bodyweight change during the first 5 days of chemotherapy as an indicator of cisplatin renal toxicity
• Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients
• What is the most informative pharmacodynamic model for paclitaxel (T)? : a 3 hour-infusion vs. 24-hour infusion.
• Association of epidermal growth factor receptor (EGFR) gene mutations with EGFR amplification in advanced non-small cell lung cancer
• Report from the second Japanese Urological Association-Japanese Society of Medical Oncology joint conference, 2007 : 'Diagnosis and treatment of urological malignant tumors : How can we promote subspecialists?'
• Problems with Registration-Directed Clinical Trials for Lung Cancer in Japan
• Phase I study of cisplatin, vinorelbine, and concurrent thoracic radiotherapy for unresectable stage III non-small cell lung cancer
• Tumor response to chemotherapy : The validity and reproducibility of RECIST guidelines in NSCLC patients
• INHIBITORY EFFECTS OF REPEATED INTRAVENOUS INJECTIONS OF DEXAMETHASONE ON PULMONARY TOXICITY OF A NEW MITOMYCIN C ANALOGUE, KW-2149, IN A NOVEL RAT MODEL
• Inhibitory effects of dexamethasone on pulmonary toxicity of a new mitomycin C analogue KW-2149 in a novel rat model.
• Prospective Evaluation of the Feasibility of Cisplatin-based Chemotherapy for Elderly Lung Cancer Patients with Normal Organ Functions
• ANTITUMOR ACTIVITY OF QUINOCARMYCIN AGAINST CARCINOMA OF THE LUNG IN HUMAN TUMOR CLONOGENIC ASSAY
• N-Glycan fucosylation of epidermal growth factor receptor modulates receptor activity and sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor
• Absence of Tumor Promoting Activity of Xylazine in a Two-stage Nasal Carcinogenesis Model in N-bis(2-hydroxypropyl)nitrosamine-treated Rats
• Enhanced Anti-tumor Effect of Trastuzumab in Combination with Cisplatin
• Long-term follow-up of patients with unresectable locally advanced non-small cell lung cancer treated with chemoradiotherapy: A retrospective analysis of the data from the Japan Clinical Oncology Group trials (JCOG0003A)
• Phase I Study of Paclitaxel by Three-hour Infusion : Hypotension Just after Infusion Is One of the Major Dose-limiting Toxicities
• MECHANISM OF FK506-INDUCED GLUCOSE INTOLERANCE IN RATS
• What are the reasons for negative phase III trials of molecular-target-based drugs?
• Epidermal growth factor receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor
• COMPARATIVE STUDIES OF PULSE AND CONTINUOUS EXPOSURE IN HUMAN TUMOR CLONOGENIC ASSAY
• THE USE OF HUMAN TUMOR CLONOGENIC ASSAY IN PREDICTING COMBINATION EFFECT OF CISPLATIN PLUS VINDESINE IN CARCINOMA OF THE LUNG
• Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification
• Genetic Polymorphisms of Copper- and Platinum Drug-efflux Transporters ATP7A and ATP7B in Japanese Cancer Patients
• Ethnic Differences of two Non-synonymous Single Nucleotide Polymorphisms in CDA Gene
• Translational and clinical studies of target-based cancer therapy
• Phase I and pharmacokinetic study of vorinostat (suberoylanilide hydroxamic acid) in Japanese patients with solid tumors
• P7-07 Is emulsification of the test substance with Freund's complete adjuvant(FCA) necessary in the guinea pig maximization test?(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION
• EFFECTS OF pH AND OSMOLALITY ON PHLEBITIC POTENTIAL OF INFUSION SOLUTIONS FOR PERIPHERAL PARENTERAL NUTRITION
• Phase I study of TLR9 agonist PF-3512676 in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer
• Summary of the ASCO-JSCO Joint Symposium
• IN VITRO CHEMOSENSITIVITY PATTERNS OF CARCINOMA OF THE LUNG IN HUMAN TUMOR CLONOGENIC ASSAY
• Bortezomib potentially inhibits cellular growth of vascular endothelial cells through suppression of G2/M transition
• Recent trends in the treatment of advanced lung cancer
• 19.Endpoints for multimodol clinical trials in stage III NSCLC(第108回日本肺癌学会関東支部会)
• A Pharmacokinetic and Pharmacodynamic Analysis of CPT-11 and Its Active Metabolite SN-38
• Prediction of Severe Adverse Drug Reactions Using Pharmacogenetic Biomarkers
• Genetic Polymorphisms of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis
• Plasma concentrations of VCAM-1 and PAI-1 : A predictive biomarker for post-operative recurrence in colorectal cancer
• "P-1 Effects of pH and Osmolality on Phlebitic Potential of infusion Solutions for Peripheral Parenteral Nutrition.
• Stochastic Properties of Prescriptions for Infectious and Non-Infectious Diseases Dispensed by a City Pharmacy
• Innovator and generic cisplatin formulations : Comparison of renal toxicity
• Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer
• Distal Promoter Regions Are Responsible for Differential Regulation of Human Orosomucoid-1 and -2 Gene Expression and Acute Phase Responses

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