EFFECTS OF pH AND OSMOLALITY ON PHLEBITIC POTENTIAL OF INFUSION SOLUTIONS FOR PERIPHERAL PARENTERAL NUTRITION

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概要

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• In this study, we investigated the phlebitic potentials of several infusion solutions for peripheral parenteral nutrition to clarify the effects of pH and osmolality on the development of infusion phlebitis. A 10% glucose solution with electrolytes (GE, pH 4.93, 727 mOsm/kg), a 10% amino acid solution (AA, pH 6.95, 929 mOsm/kg), or a 5:2 admixture of GE and AA (GEAA, pH 6.46, 779 mOsm/kg) was infused into the rabbit ear vein for 6 hr at 10 mL/kg/hr, and the infused veins were examined histopathologically. Both GE and AA caused phlebitic changes, such as loss of venous endothelial cells, inflammatory bell infiltration, and perivascular edema. However, their admixture, GEAA, caused scant phlebitic changes. These results were as follows: 1) rabbit peripheral veins could tolerate the pH (6.46) and the osmolality (779 mOsm/kg) of GEAA under the conditions of this study;2) GE caused phlebitis due to its acidity (PH 4.93); 3) AA caused phlebitis due to its hyperosmolslity (929 mOsm/kg); and 4) mixing GE and AA eliminated the factors causing phlebitis in each solution. The admixture of GE and another 10% amino acid solution (AB, pH 6.04) at the ratio of 5:2 (GEAB, pH 5.76, 758 mOsm/kg) caused phlebitic changes. Since its osmolality was lower than that of GEAA, it was considered that GEAB caused phlebitic changes due to its acidity (pH 5.76), which was attributed to the acidic amino acid solution used as a component.

• 日本トキシコロジー学会の論文
• 1998-02-13

著者

• Tamura T

  Division Of Internal Medicine National Cancer Center Hospital

• Tamura Tomohide

  国立がんセンター中央病院 腫瘍内科

• Tamura T

  National Cancer Center Hospital Tokyo

• Tamura Tomohide

  Medical Oncology Division National Cancer Center Hospital

• Tagawa Toshiaki

  国立がんセンター中央病院 消化器内科

• KANEDA Shinya

  Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.

• Tamura Tomohide

  Division Of Internal Medicine National Cancer Center Hospital

• KUWAHARA Takashi

  Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.

• ASANAMI Shougo

  Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.

• Kaneda S

  Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.

• Kaneda Shinya

  Naruto Research Institute Otsuka Pharmaceutical Factory Inc.

• Asanami Shougo

  Naruto Research Institute Otsuka Pharmaceutical Factory Inc.

• TAMURA Takumi

  Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.

• Kuwahara Takashi

  Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.

• Kuwahara Takashi

  Naruto Research Institute Otsuka Pharmaceutical Factory Inc.

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