GONADAL TOXICITY OF AN ETHANOL EXTRACT OF PSORALEA CORYLIFOLIA IN A RAT 90-DAY REPEATED DOSE STUDY

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概要

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• Ethanol extracts of seeds of Psoralea corylifolia are proposed as food additives for processed food preservation. An extract was administered by admixing into diet at concentrations of 0, 0.375, 0.75, 1.5 or 3.0% to 10 male and 10 female F344 rats each for 90 days to evaluate its toxicity. Body weight gain, food consumption and food conversion efficiency (body weight gain per food consumption) were lower in the extract-treated animals, except for the 0.375% males, as compared to the control animals. Absolute and/or relative testes weights in the 1.5 and 3.0% groups and those of ovaries in the 3.0% group were significantly (p<0.01) lower than in the control group. On histopathological examination, seminiferous tubular atrophy and Leydig cell atrophy in the testes, and epithelial cell atrophy in the seminal vesicles and prostate were observed in the 1.5 and 3.0% males. Decrease in the number of corpora lutea associated with frequent necrotic follicles in the ovaries in the 1.5 and 3.0% females and less frequent endometrial glands in the uterus in the 3.0% females were also detected. These results might suggest disruption of the hypothalamus-pituitary-gonadal axis in Psoralea corylifolia-treated rats as possible mechanisms underlying this gonadal toxicity.

• 日本トキシコロジー学会の論文
• 2002-05-17

著者

• Imai Toshio

  Division of Pathology, National Institute of Health Sciences

• Hirose Masao

  Division of Pathology, National Institute of Health Sciences

• Mori H

  Division Of Pathology National Institute Of Health Sciences

• Mitsumori Kunitoshi

  東京大学医科学研究所 癌細胞シグナル分野

• TAKIZAWA Tamotsu

  Division of Pathology, National Institute of Health Sciences

• UEDA Makoto

  Division of Pathology, National Institute of Health Sciences

• ONODERA Hiroshi

  Division of Pathology, National Institute of Health Sciences

• Yasuhara K

  Division Of Pathology National Institute Of Health Sciences

• Yasuhara Kazuo

  Divisions Of Toxicology National Institute Of Hygienic Sciences

• Yasuhara Kazuo

  Division Of Pathology National Institute Of Health Sciences

• TAKAGI Hisayoshi

  Division of Pathology, National Institute of Health Sciences

• TAMURA Toru

  Division of Pathology, National Institute of Health Sciences

• MITSUMORI Kunitoshi

  Division of Pathology, National Institute of Health Sciences

• Takizawa Tamotsu

  東京農工大学

• Takizawa Tamotsu

  Division Of Pathology National Institute Of Health

• Takizawa Tamotsu

  Division Of Pathology National Institute Of Health Sciences

• Hirose Masao

  国立医薬品食品衛生研究所 病理

• Tamura Toru

  Division Of Pathology National Institute Of Health Sciences

• Takagi Hisayoshi

  国立医薬品食品衛生研究所

• Takagi Hisayoshi

  Division Of Pathology National Institute Of Health Sciences

• Onodera Hiroshi

  東京都健康安全研究センター

• 小野寺 博志

  Division Of Pathology National Institute Of Health Sciences

• Onodera Hiroshi

  Pharmaceuticals And Medical Devices Agency

• Tamura Tomohide

  Medical Oncology Division National Cancer Center Hospital

• Kodama Yukio

  Division Of Pathology National Institute Of Health Sciences

• Kitamura Y

  Division Of Pathology National Institute Of Health Sciences

• 安原 加壽雄

  San-ei Gen F.f.i. Inc.

• Kurokawa Y

  Division Of Toxicology National Institute Of Health Sciences

• Hirose Masao

  Division Of Pathology National Institute Of Health Sciences

• Hirose Masao

  Div. Pathol. Natl. Inst. Htlh. Sci.

• Mitsumori Kunitoshi

  Division Of Pathology National Institute Of Health Sciences

• 今井 淑夫

  Division Of Pathology National Institute Of Health Sciences

• 今井 淑夫

  東京工業大学部有機材科工学科

• Ueda Makoto

  Division Of Pathology National Institute Of Health Sciences

• Kamimura Yasuhiro

  Safety Evaluation Lab. Yoshitomi Pharm.

• Onodera H

  Pharmaceuticals And Medical Devices Agency

• 三森 国敏

  Division Of Pathology National Institute Of Health Sciences

• Usami Makoto

  Division Of Pharmacology Biological Safety Research Center National Institute Of Health Sciences

• Kashida Y

  Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology

• Kodama Yukio

  Cel. Mol. Tox. Div. Nihs

• Matsumoto K

  Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology

• Usami M

  Division Of Pathology National Institute Of Health Sciences

• Onodera Hiroshi

  Dvision Of Pathology Biological Safety Research Center National Institute Of Health Sciences

• Yasuhara Kazuo

  Division Of Medicinal Chemistry And Pharmacognosy Ohio State University

• Imai Toshio

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Ueda Makoto

  Division Of Mathematical Sciences Graduate School Of Science And Technology Chiba University

• Tamura Toru

  Div. Of Pathology Nihs

• Tamura Toru

  Division Of Pathology National Institute Of Health

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