Lack of Modifying Effects of Cinnamaldehyde on Development of Lung Proliferative Lesions Induced by Urethane in Transgenic Mice Carrying the Human Prototype c-Ha-ras Gene
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the modifying effects of cinnamaldehyde (CNMA) on the development of lung proliferative lesions, male transgenic mice carrying the human prototype c-Ha-ras gene (rasH2 mice) were given a single intraperitoneal injection of 250 mg/kg urethane (UR) or saline (vehicle control), followed by a diet containing 0.5% CNMA or basal diet, respectively, for 26 weeks. Their non-transgenic CB6F1 littermates (non-Tg mice) were also treated in the same manner. In rasH2 mice, alveolar/bronchiolar hyperplasias were observed in all treated groups including untreated controls, and adenomas were induced in the treated groups except for CNMA-alone group. However, there were no significant intergroup differences in the incidences and multiplicities of these lesions. In addition, although carcinomas were found in both UR-alone and UR+CNMA groups, there was no significant differences in the incidences and multiplicities between them. In non-Tg mice, alveolar/bronchiolar hyperplasias were observed in both untreated control and UR+CNMA groups with no significant differences in the incidences and multiplicities. Adenomas were induced in all treated groups except for CNMA-alone group in non-Tg mice, the incidences and multiplicities were lower than those in rasH2 mice and no significant intergroup differences were observed. There were no significant intergroup differences between UR-alone and UR+CNMA groups in the PCNA labeling indices of adenomas or carcinomas and the areas of adenomas or carcinomas to whole examined area of lungs. The present results suggest that the CNMA treatment under the present experimental conditions does not influence on the development of lung proliferative lesions induced by urethane in both rasH2 mice and non-Tg mice.
著者
-
Hirose Masao
Division of Pathology, National Institute of Health Sciences
-
TAKIZAWA Tamotsu
Division of Pathology, National Institute of Health Sciences
-
ONODERA Hiroshi
Division of Pathology, National Institute of Health Sciences
-
Yasuhara Kazuo
Divisions Of Toxicology National Institute Of Hygienic Sciences
-
TAKAGI Hisayoshi
Division of Pathology, National Institute of Health Sciences
-
TAMURA Toru
Division of Pathology, National Institute of Health Sciences
-
MITSUMORI Kunitoshi
Division of Pathology, National Institute of Health Sciences
-
Takizawa Tamotsu
Division Of Pathology National Institute Of Health
-
Hirose Masao
国立医薬品食品衛生研究所 病理
-
Koujitani Takatoshi
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 1
-
Hayashi Yuzo
Department of Pharmaceutical Sciences, Kitasato University, 5-9-1, Shirogane, Minato-ku, Tokyo 108-0
-
Takagi Hisayoshi
Division Of Pathology National Institute Of Health Sciences
-
Onodera Hiroshi
東京都健康安全研究センター
-
Onodera Hiroshi
Pharmaceuticals And Medical Devices Agency
-
Koujitani Takatoshi
国立医薬品食品衛生研究所
-
Koujitani Takatoshi
Division Of Pathology National Institute Of Health Sciences
-
Hirose Masao
Division Of Pathology National Institute Of Health Sciences
-
Mitsumori Kunitoshi
Division Of Pathology National Institute Of Health Sciences
-
Yasuhara Kazuo
Division Of Medicinal Chemistry And Pharmacognosy Ohio State University
-
Hayashi Yuzo
Department Of Cardiology Kasugai Municipal Hospital
-
Tamura Toru
Division Of Pathology National Institute Of Health
-
Takizawa Tamotsu
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501
-
Mitsumori Kunitoshi
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501
-
Koujitani Takatoshi
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501
-
Tamura Toru
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501
-
Yasuhara Kazuo
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501
-
Hirose Masao
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501
-
Takagi Hisayoshi
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501
-
Onodera Hiroshi
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501
関連論文
- A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats
- Lack of modifying effects of prepubertal exposure to acrylamide (AA) on N-methyl-N-nitrosourea (MNU)-induced multi-organ carcinogenesis in F344 rats
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points
- DNA Adduct Formation, Nucleolar Segregation and Cell Proliferation in Rats Treated with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
- Depression of T cell-mediated immunity reduces sulfadimethoxine-induced capsular inflammation and inhibits associated development of invasive thyroid follicular cell carcinomas in rats
- Lack of enhancement of susceptibility to mammary and thyroid carcinogenesis in rats exposed to DMBA and DHPN following prepubertal iodine deficiency
- In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Comparison of enhancing effects of different goitrogen treatments in combination with β-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds
- In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Lack of Modifying Effects of Combined Treatment of t-butylhydroquinone and Sodium Nitrite on Forestomach Carcinogenesis in rasH2 Mice Initiated with N-ethyl-N-nitrosourea
- Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
- Tumorigenic Susceptibility of Catechol on the Gastric Mucosa in rasH2 Mice
- Lack of Modifying Effect of Glycerol in Pulmonary Carcinogenesis in rasH2 Mice Induced by Urethane or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
- LACK OF MODIFYING EFFECTS OF EUGENOL ON DEVELOPMENT OF LUNG PROLIFERATIVE LESIONS INDUCED BY URETHANE IN TRANS-GENIC MICE CARRYING THE HUMAN PROTOTYPE c-Ha-ras GENE
- Lack of Modifying Effects of Cinnamaldehyde on Development of Lung Proliferative Lesions Induced by Urethane in Transgenic Mice Carrying the Human Prototype c-Ha-ras Gene
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- P7-44 Toxicity Evaluation of Bt protein with 28-days dietary administration to gastric-acid reduced rat models(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-43 Screening of chemopreventive agents using a medium-term pancreas carcinogenesis model in hamsters(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate
- Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl) nitrosamine in rats after initiation
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- A possible role of oxidative stress in potassium bromate (KBrO_3) carcinogenesis (ACTIVE OXYGEN) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Safety evaluetion of Bt protein by dietary administration to a gastro-intestinal impairment rat model (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Promoting Effects of Ethinylestradiol but not Atrazine on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in ICR Mice
- Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl) nitrosamine
- Modifying Effects of 2,6-Dimethylaniline on Nasal Carcinogenesis in RasH2 Mice Initiated with 4-Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Lack of Modifying Effects of 2,6-Dimethylaniline on Lung Carcinogenesis in Transgenic Mice Carrying Human Prototype c-Ha-ras Gene Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Difference in the Types of Uterine Tumors between Heterozygous p53-deficient and Wild Type CBA Mice Treated with Ethinylestradiol after N-ethyl-N-nitrosourea Initiation
- Modifying effect of atrazine on DMBA-induced mammary carcinogenesis in ovariectomized rats.(GENERAL SESSION BY POSTER PRESENTATION)(CARCINOGENICITY)
- Effects of Antioxidant 1-O-Hexy1-2,3,5-trimethylhydroquinone or Ascorbic Acid on Carcinogenesis Induced by Administration of Aminopyrine and Sodium Nitrite in a Rat Multi-organ Carcinogenesis Model
- Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis : Results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- A Preliminary Study of the Effect of Plantago Ovata Forsk on the Development of 7, 12-Dimethylbenz[a]anthracene-initiated Rat Mammary Tumors under the Influence of Hypercholesterolemia
- Establishment of an in vivo Highly Metastatic Rat Hepatocellular Carcinoma Model
- Combined Chemopreventive Effects of Perilla or Corn Oil and Indomethacin in a Rat Medium-Term Multiorgan Carcinogenesis Model
- Modifying Effects of Genistein, 4-Nonylphenol and Methoxychlor on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in RasH2 Transgenic Mice Harboring a Human Prototype C-Ha-ras Gene
- The Mouse rasH2/BHT Model as an in vivo Rapid Assay for Lung Carcinogens
- Enhancing Effects β-Estradiol 3-Benzoate but Not Methoxychlor on the Promotion/Progression Stage of Chemically-induced Mammary Carcinogenesis in Ovariectomized Rats
- GONADAL TOXICITY OF AN ETHANOL EXTRACT OF PSORALEA CORYLIFOLIA IN A RAT 90-DAY REPEATED DOSE STUDY
- The Utility of N-nitrosamines as Initiators for a 26-Week Rat Two-Stage Nasal Carcinogenesis Model
- Enhancement by Cigarette Smoke Exposure of 2-Amino-3,8-dimethylimidazo [4,5-f] quinoxaline-induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- Development of invasive follicular cell carcinomas in a rat thyroid carcinogenesis model : Biological impact of capsular inflammation and reduced cyclooxygenase-2 expression
- Involvement of Lipid Peroxidation in Spontaneous Pancreatitis in WBN/Kob Rats
- Possible enhancing effects of atrazine on growth of 7, 12-dimethylbenz(a) anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats
- THYROID PROLIFERATIVE LESIONS INDUCED BY ANTI-THYROID DRUGS IN RATS ARE NOT ALWAYS ACCOMPANIED BY SUSTAINED INCREASES IN SERUM TSH
- Renal Carcinogenicity of Concurrently Administered Fish Meal and Sodium Nitrite in F344 Rats
- TIME COURSE OBSERVATION OF THYROID PROLIFERATIVE LESIONS AND SERUM LEVELS OF RELATED HORMONES IN RATS TREATED WITH KOJIC ACID AFTER DHPN INITIATION
- Inhibition by β-Carotene of Upper Respiratory Tumorigenesis in Hamsters Receiving Diethylnitrosamine Followed by Cigarette Smoke Exposure
- IMMUNOHISTOCHEMICAL STUDIES OF TSH-PRODUCING CELLS IN THE PITUITARY AND EXPRESSION OF GROWTH FACTORS IN THYROIDAL PROLIF-ERATIVE LESIONS IN RATS TREATED WITH THIOUREA AND EXCESS VITAMIN A
- "P-42 Protective Effect of Lecithinization-Superoxide Dismutase Against Monocrotaline Induced Lung Injuries
- "P-41 A Morphometric study on the time course change of thyrotroph hypertrophy in the pituitary of rats treated with a goitrogen.
- Synergistic Effects of High-dose Soybean Intake with Iodine Deficiency, but Not Sulfadimethoxine or Phenobarbital, on Rat Thyroid Proliferation
- Lack of Effect of Soy Isoflavone On Thyroid Hyperplasia in Rats Receiving an Iodine-deficient Diet
- P-14 Effects of antioxidants on spontaneous hepatic and renal lesions in LEC rats.(Proceedings of the 27th Annual Meeting)
- Lack of Modification by Environmental Estrogenic Compounds of Thyroid Carcinogenesis in Ovariectomized Rats Pretreated with N-bis(2-hydroxynronyl)nitrosamine (DHPN)
- Lack of Modifying Effects of Environmental Estrogenic Compounds on the Development of Thyroid Proliferative Lesions in Male Rats Pretreated with N-Bis(2-hydroxypropyl)nitrosamine(DHPN)
- Inhibitory Effects of 1'-Acetoxychavicol Acetate on N-Nitrosobis(2-oxopropyl)-amine-induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
- Concurrent Administration of Fish Meal and Sodium Nitrite Does not Promote Glandular Stomach Carcinogenesis in Rats after Treatment with N-methyl-N'-nitro-N-nitrosoguanidine
- 22D-10-1 Effects of Oltipraz on Spontaneous Hepatitis of LEC Rats.
- INFLUENCES OF LONG-TERM ADMINISTRATION OF 24R, 25-DIHYDROXYVITAMIN D_3, A VITAMIN D_3 DERIVATIVE, IN RATS
- Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model
- Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods-a preliminary study
- Harman and Norharman Suppressed but NaNO_2 Enhanced the Development of Preneoplastic Liver Cell Foci in 2-Amino-3,8-Dimethylimidazo[4,5-f]Quinoxaline (MeIQx)-Treated Rats
- DOSE-THRESHOLD FOR THYROID TUMOR-PROMOTING EFFECTS OF ORALLY AMINISTERED KOJIC ACID IN RATS AFTER INITIATION WITH N-bis(2-HYDROXYPROPYL) NITROSAMINE
- CAPACITY FOR INDUCTION OF THYROID PROLIFERATIVE LESIONS BY ANTI-THYROID DRUGS WITH DIFFERENT TOXIC MECHANISMS
- TIME COURSE OBSERVATION OF THYROID PROLIFERATIVE LESIONS AND SERUM TSH LEVELS IN RATS TREATED WITH THIOUREA AFTER DHPN INITIATION
- RELATIONSHIP BETWEEN INDUCTION-DOSES OF THYROID TUMORS BY ANTI-THYROID DRUGS AND PLASMA LEVELS OF T_3, T_4 AND TSH
- TOXICITY AND BLOOD CONCENTRATIONS OF XYLAZINE AND ITS METABOLITE, 2, 6-DIMETHYLANILINE, IN RATS AFTER SINGLE OR CONTINUOUS ORAL ADMINISTRATIONS
- 21B-04-1 Preliminary Repeated Dose (28 Days) Oral Toxicity Study of Flutamide to Establish the Efficacy of the "Enhanced OECD Test Guideline 407" in Rats.
- Absence of Tumor Promoting Activity of Xylazine in a Two-stage Nasal Carcinogenesis Model in N-bis(2-hydroxypropyl)nitrosamine-treated Rats
- O-14 Mechanistic studies on testicular toxicity of Psoralea corylifolia extract in rats.(Proceedings of the 27th Annual Meeting)
- CONFIRMATION STUDY, USING NITROBENZENE, OF THE COMBINED REPEAT DOSE AND REPRODUCTIVE/DEVELOPMENTAL TOXICITY TEST PROTOCOL PROPOSED BY THE ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT (OECD)
- Prevention of Stroke by a Japanese Traditional Medicine, Shichimotsu-koka-to, in Stroke-Prone Spontaneously Hypertensive Rats-a Histopathological Study
- Preventive Effects of Shinchimotsu-koka-to on Renal Lesions in Stroke-Prone Spontaneously Hypertensive Rats
- MORPHOLOGICAL EVALUATION OF CYCLOPHOSPHAMIDE TESTICULAR TOXICITY IN RATS USING QUANTITATIVE MORPHOMETRY OF SPERMATOGENIC CYCLE STAGES
- TESTICULAR TOXICITY EVALUATION OF CYCLOPHOSPHAMIDE BY QUANTITATIVE MORPHOMETRY OF SPERMATOGENIC CYCLE STAGES
- Molecular profiling of genes showing altered expression in the livers of rats treated with non-genotoxic hepatocarcinogens for long-term (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- STUDY OF EXAMINATION METHODS FOR ASSESSING MALE FERTILITY DISTURBANCES 1.QUANTITATIVE MORPHOMETRICAL EVALUATION OF TESTICULAR TOXICITY OF ADRIAMYCIN
- Mutagenicity of Combined Treatment with Sodium Nitrite and Ascorbic Acid in Bacterial and Mammalian Cells
- Problems in the risk assessment of carcinogenic chemicals : from the viewpoint of long-term carcinogenicity studies (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)
- Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation
- Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay
- Gene Expression Profiling and Cellular Distribution of Molecules with Altered Expression in the Hippocampal CA1 Region after Developmental Exposure to Anti-Thyroid Agents in Rats
- SPONTANEOUS MESOTHELIOMAS IN F344 RATS : A LIGHT AND ELECTRON MICROSCOPICAL STUDY
- Prevention of Stroke by a Japanese Traditional Medicine, Shichimotsu-koka-to, in Stroke-Prone Spontaneously Hypertensive Rats : a Histopathological Study
- Susceptibility of Heterozygous p53 Deficient CBA Mice to Induction of Liver Proliferative Lesions by Phenobarbital after Dimethylnitrosamine Initiation
- Modifying Effects of Endocrine Disrupting Chemicals on N-bis (2-hydroxypropyl) Nitrosamine and Sulfadimethoxine-Induced Thyroid Carcinogenesis in Rats
- Lack of Modifying Effects of Cinnamaldehyde on Development of Lung Proliferative Lesions Induced by Urethane in Transgenic Mice Carrying the Human Prototype c-Ha-ras Gene
- Modifying Effects of Flumequine on Dimethylnitrosamine-Induced Hepatocarcinogenesis in Heterozygous p53 Deficient CBA Mice