Prevention of Stroke by a Japanese Traditional Medicine, Shichimotsu-koka-to, in Stroke-Prone Spontaneously Hypertensive Rats : a Histopathological Study

概要

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Efffect of chronic administration of a Japanese traditional medicine, Shichimotsu-koka-to (SKT) on the incidence of apoplexy was investigated in stroke-prone spontaneously hypertensive rats (SHRSPs). SHRSP fed with SKT extract at 1.5 g/kg/day from 8 through 23 weeks of age showed significantly lower incidence of stroke, although the inherent age-dependent elevation of systolic blood pressure was hardly affected. SHRSP at 23 weeks of age showed hemorrhages, calcification, spongiosis, reticulating colliquation, gliosis and large cysts in the brain. The area and incidence of these cerebral lesions were significantly less in SKT-treated animals. These observations suggest that the SKT-induced prevention of stroke contributes to the prolongation of the life span of SHRSP that we have previously reported.
日本生薬学会の論文
2003-02-20