THE EFFECT OF TESTOSTERONE PROPIONATE SUPPLEMENT ON TESTICULAR TOXICITY WITH THIAMPHENICOL IN MALE SPRAGUE-DAWLEY RATS
スポンサーリンク
概要
- 論文の詳細を見る
Testosterone propionate (TP) was supplemented to male rats for assessment of its ameliorating effect on testicular toxicity with thiamphenicol (TAP). A total of 20 male Sprague-Dawley rats were treated orally with TAP at 200 mg/kg/day for up to 4 weeks. In addition, 5 male rats were allotted to the control group receiving vehicle only. Ten of the 20 treated rats had a Silastic capsule^〓 (containing about 80 mg of TP) implanted in the dorsal skin at Week 2 and assigned to the TAP-TP group, while the other 10 treated rats were in the TAP group. After Weeks 3 and 4, five of both treated groups were examined for weight and histology of the testis and accessory genital glands, and for staging analysis of the seminiferous tubules. The same parameters were also assessed in the control group after Week 4. Weights and morphology of the seminal vesicle and prostate recovered remarkably from the TAP toxicity after TP supplement. However, no ameliorating effects of TP were obtained for the testis in either weight, morphology, or staging analysis of the seminiferous tubules.
- 日本トキシコロジー学会の論文
- 2004-08-30
著者
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
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Kosaka Tadashi
The Institute of Environmental Toxicology
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Harada Takanori
The Institute of Environmental Toxicology
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Mitsumori Kunitoshi
杏林製薬研究センター
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Maita Keizo
The Institute of Environmental Toxicology
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Kuwahara Maki
The Institute of Environmental Toxicology
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Inui Kosei
Central Research Institute Ishihara Sangyo Kaisha Ltd.
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Inui Kosei
残留農薬研究所
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Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
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Kuwahara M
Inst. Environmental Toxicology Ibaraki Jpn
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Kuwahara Maki
Laboratory Of Pathology Toxicology Division Chemistry Division Institute Of Environmental Toxicology
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Harada Tomoko
協和醗酵工業
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Harada Tomoko
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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MITSUMORI Kunitoshi
Institute of Environmental Toxicology
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TAKAHASHI Kazuaki
Institute of Environmental Toxicology
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原田 孝則
The Institute of Environmental Toxicology
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Kosaka T
Toxicology Division Institute Of Environmental Toxicology
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TAKAHASHI Naofumi
The Institute of Environmental Toxicology
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SUGIMOTO Kayoko
Formerly, The Institute of Environmental Toxicology
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KASHIMOTO Yukiko
The Institute of Environmental Toxicology
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Sugimoto Kayoko
Formerly The Institute Of Environmental Toxicology
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Kosaka T
Inst. Environmental Toxicology Tokyo Jpn
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Mitsumori K
The Institute Of Environmental Toxicology:agrotox Inc.
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Tanaka Naoki
Laboratory Of Animal Management And Testing Chemistry Division Institute Of Environmental Toxicology
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Takahashi Kazuaki
Institute Of Environmental Toxicology:(present Address)nippon Veterinary & Zootechnical College
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Takahashi N
The Institute Of Environmental Toxicology
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