Modifying effect of Siraitia grosvenori extract on piperonyl butoxide-promoted hepatocarcinogenesis in rats
スポンサーリンク
概要
- 論文の詳細を見る
To examine the possible modifying effect of the extract of Siraitia grosvenori (SGE), a naturally occurring antioxidative agent, on piperonyl butoxide (PBO)-promoted hepatocarcinogenesis, male F344 rats were administered a single intraperitoneal injection of N-diethylnitrosamine (DEN) as an initiator followed by administration of a diet containing 2% PBO for 7 weeks with or without SGE (1,000 ppm) in the drinking water. To enhance cellular proliferation, all animals underwent two-thirds partial hepatectomy 1 week after the commencement of PBO administration. Pretreatment with SGE was also applied to the PBO + SGE group for 2 weeks prior to DEN initiation. Liver immunohistochemistry revealed that although the PBO-mediated increase in the number of glutathione S-transferase placental form (GST-P)-positive foci and proliferating cell nuclear antigen-positive cells remained unaltered with SGE coadministration, the area of the GST-P-positive foci was increased. On the contrary, real-time RT-PCR showed hat coadministration of SGE increased hepatic GST and glutathione peroxidase (GSH-Px) antioxidant activities and mRNA expression levels of the phase II enzymes that are known to be transcriptionally up-regulated through the Nrf 2-Keapl -antioxidant responsive element (ARE) as well as the phase III enzymes. Furthermore, measurement of thiobarbituric acid-reactive substances showed a decrease in lipid peroxidation by SGE coadministration. The results suggest that SGE may exert hepatic antioxidant activity by up-regulating the genes under the control of the Nrf 2-Keapl-ARE transcriptional machinery; however, this activity was neither effective nor sufficient for suppression of PBO-promoted early hepatocarcinogenesis.
- 日本トキシコロジー学会の論文
- 2008-05-01
著者
-
DEWA Yasuaki
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
NISHIMURA Jihei
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
SHIBUTANI Makoto
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
MITSUMORI Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Mitsumori Kunitoshi
東京大学医科学研究所 癌細胞シグナル分野
-
Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
-
Mitsumori K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
三森 国敏
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Murata Yuji
Biochemical Laboratory, Saraya Company, Ltd.
-
Yasuno Hironobu
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
Muguruma Masako
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
Takabatake Masayoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
Muguruma Masako
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Dewa Yasuaki
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Dewa Yasuaki
東京農工大学 獣医病理学
-
Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
-
Mitsumori Kunitoshi
Department Of Pathology National Institute Of Health Sciences
-
Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Division Of Animal Science Institute Of Symbiotic Science And Tec
-
Murata Yuji
Biochemical Laboratory Saraya Company Ltd.
-
Yasuno Hironobu
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Shibutani Makoto
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Shibutani Makoto
Division Of Pathology National Institute Of Health Sciences
-
Takabatake Masayoshi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Matsumoto K
Kyushu Univ. Fukuoka Jpn
-
Matsumoto K
Drug Safety Research Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.:l
-
三森 国敏
Division Of Pathology National Institute Of Health Sciences
-
Matsumoto K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Nishimura Jihei
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Nishimura Jihei
Laboratory Of Applied Physiology Faculty Of Agriculture Kobe University Graduate School Of Science A
-
Murata Yuji
Biochemical Laboratory Saraya Co. Ltd.
関連論文
- The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice
- A Mixed Apocrine Gland Tumor with Metastases to the Bone and Bone Marrow in a Miniature Poodle
- Low dose effects of dichlorodiphenyltrichloroethane (DDT) on gene transcription and DNA methylation in the hypothalamus of young male rats : implication of hormesis-like effects
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Lack of Modifying Effects of Combined Treatment of t-butylhydroquinone and Sodium Nitrite on Forestomach Carcinogenesis in rasH2 Mice Initiated with N-ethyl-N-nitrosourea
- Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
- Tumorigenic Susceptibility of Catechol on the Gastric Mucosa in rasH2 Mice
- Lack of Modifying Effect of Glycerol in Pulmonary Carcinogenesis in rasH2 Mice Induced by Urethane or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Promoting Effects of Ethinylestradiol but not Atrazine on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in ICR Mice
- Modifying Effects of 2,6-Dimethylaniline on Nasal Carcinogenesis in RasH2 Mice Initiated with 4-Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Lack of Modifying Effects of 2,6-Dimethylaniline on Lung Carcinogenesis in Transgenic Mice Carrying Human Prototype c-Ha-ras Gene Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Difference in the Types of Uterine Tumors between Heterozygous p53-deficient and Wild Type CBA Mice Treated with Ethinylestradiol after N-ethyl-N-nitrosourea Initiation
- Modifying effect of atrazine on DMBA-induced mammary carcinogenesis in ovariectomized rats.(GENERAL SESSION BY POSTER PRESENTATION)(CARCINOGENICITY)
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Crosstalk between PTEN/Akt2 and TGFβ signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model
- A Case Report of a Cerebellar Neuroblastoma in a p53 Null Mutation Mouse(Pathology)
- Suppressive effect of Siraitia grosvenorii extract on dicyclanil-promoted hepatocellular proliferative lesions in male mice
- In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens
- Modifying effect of Siraitia grosvenori extract on piperonyl butoxide-promoted hepatocarcinogenesis in rats
- Concurrent administration of ascorbic acid enhances liver tumor-promoting activity of kojic acid in rats
- Reactive Oxygen Species Are Possibly Involved in the Mechanism of Flumequine-Induced Hepatocarcinogenesis in Mice
- Molecular Analysis on the Possible Mechanism of β-Naphthoflavone-Induced Hepatocarcinogenesis in Rats
- Molecular Pathological Analysis of Apoptosis Induced in Testicular Germ Cells after a Single Administration of Mono-(2-ethylhexyl) phthalate to F344 Rats
- The expression of Ras-related molecules in DMBA-induced forestomach tumors in rasH2 mice(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- In vitro genotoxic potential and liver initiation activity of ciprofloxacin(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Mechanistic study on hepatocarcinogenesis induced by dicyclanil in mice : possible involvement of oxidative stress(Proceedings of the 32nd Annual Meeting)
- Induction of Hepatocellular Proliferative Lesions in CBA Mice by a 26-week Dietary Administration of Kojic Acid
- Absence of DNA Damage in Comet Assay and Liver Initiation Activity of Cinnamaldehyde
- O-16 Analysis of gene expression profiles of forestomach tumors in rasH2 mice initiated with N-ethyl-N-nitrosourea(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st
- Modifying Effects of Genistein, 4-Nonylphenol and Methoxychlor on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in RasH2 Transgenic Mice Harboring a Human Prototype C-Ha-ras Gene
- Enhancing Effects β-Estradiol 3-Benzoate but Not Methoxychlor on the Promotion/Progression Stage of Chemically-induced Mammary Carcinogenesis in Ovariectomized Rats
- GONADAL TOXICITY OF AN ETHANOL EXTRACT OF PSORALEA CORYLIFOLIA IN A RAT 90-DAY REPEATED DOSE STUDY
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- O-16 Analysis of gene expression profiles of forestomach tumors in rasH2 mice initiated with N-ethyl-N-nitrosourea(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Analysis of Gene Expression Profile on Uterine Tumorigenesis Initiated with N-ethyl-N-nitrosourea and Inhibited by Ethinylestradiol in rasH2 Mice
- THIRTEEN-WEEK REPEATED DOSE TOXICITY OF RICE BRAN GLYCOSPHINGOLIPID IN WISTAR HANNOVER (GALAS) RATS
- THIRTEEN-WEEK REPEATED DOSE TOXICITY STUDY OF WORMWOOD (ARTEMISIA ABSINTHIUM) EXTRACT IN RATS
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Investigation on liver initiation activity and DNA damages of flumequine in mice.(GENERAL SESSION BY ORAL PRESENTATION)(CARCINOGENICITY)
- A case report of a renal mixed epithelial and stromal tumor in a heterozygous S1P2 receptor deficient mouse
- Optimization of Enhancement of Therapeutic Efficacy of Ultrasound : Frequency-Dependent Effects on Iodine Formation from KI-Starch Solutions and Ultrasound-Induced Killing of Rat Thymocytes
- Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
- Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
- A Case Report of an Uncommon Sex-Cord Stromal Tumor consisted of Luteal and Sertoli Cells in a Spayed Bitch
- Possible enhancing effects of atrazine on growth of 7, 12-dimethylbenz(a) anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats
- O-13 Genotoxic potential in vitro and liver initiation activity of norfloxacin(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- O-12 Molecular pathological analyses on hepatocarcinogenesis induced by dicyclanil in mouse two-stage liver carcinogenesis model(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- MULTIPLICITY OF SPONTANEOUS LUNG TUMORS IN CD-1 MICE
- SPONTANEOUS TUMORS IN F344/DuCrj RATS FROM 12 CONTROL GROUPS OF CHRONIC AND ONCOGENICITY STUDIES
- 24-MONTH CHRONIC TOXICITY STUDY WITH GUAZATINE IN MICE
- 24-MONTH CHRONIC TOXICITY STUDY WITH GUAZATINE IN RATS
- RENAL TUMOR INDUCED BY METHYLMERCURY CHLORIDE IN ICR MICE
- SUBACUTE TOXICITY STUDIES WITH ZNSO_4 IN RATS AND MICE (The 6th Meeting for the Study of Toxic Effect)
- THIRTY-MONTH CHRONIC TOXICITY STUDIES WITH METHYL MERCURY CHLORIDE IN RATS (The 5th Meeting for the Study of Toxic Effect)
- Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver
- THIRTY-MONTH CHRONIC TOXICITY STUDIES WITH ZINC ETHYLENE BISDITHIOCARBAMATE (ZINEB) IN RATS (The 6th Meeting for the Study of Toxic Effect)
- TWENTY-FOUR-MONTH CHRONIC TOXICITY STUDIES WITH DICHLORODIISOPROPYLETHER (DCIP) IN RATS (The Fourth Meeting for the Study of Toxic Effect)
- TWENTY-FOUR-MONTH CHRONIC TOXICITY STUDIES WITH DICHLORODIISOPROPYLETHER (DCIP) IN MICE (The Fourth Meeting for the Study of Toxic Effect)
- 214. CHRONIC TOXICITY STUDIES IN RATS WITH METHYL MERCURY CHLORIDE (The Third Meeting for the Study of Toxic Effect)
- ABSENCE OF IN VIVO GENOTOXICITY AND LIVER INITIATION ACTIVITY OF DICYCLANIL
- Ultrastructural Morphology of Motor Endplate Neurotoxicities in Rats
- 6例のF344ラットの耳介に発生した無色素性黒色腫〔英文〕
- THIRTEEN-WEEK SUBACUTE TOXICITY STUDY OF 4-BROMOPHENYL CHLOROMETHYL SULFONE (BCS) IN RATS
- SPONTANEOUS RADICULONEUROPATHY IN AGING RATS
- TWENTY FOUR-MONTH CHRONIC TOXICITY STUDY WITH BIS (DIMETHYLTHIOCARBAMOYL) DISULFIDE (THIRAM) IN BEAGLES
- DELAYED NEUROTOXICITY STUDIES IN JAPANESE QUAIL (The 6th Meeting for the Study of Toxic Effect)
- The Influence of Pre- and Post-natal Exposure to Methoxychlor on the Immune System and Renal Function of Sprague-Dawley Rats
- Age-Related Hematological Changes in Normal F344 Rats: during the Neonatal Period
- Point Mutations of the c-H-ras Gene in Spontaneous Pulmonary Tumors of Transgenic Mice Carrying the Human c-H-ras Gene
- Immunohistochemical demonstration of ornithine decarboxylase (ODC) expression in altered liver cell foci of rats treated with peroxisome proliferators.
- Evaluation of carcinogenicity on chemicals using transgenic mice
- Alterations in the Developing Immune System of the Rat after Perinatal Exposure to Methoxychlor
- P11-10 Kidney damages induced by tetrabromobisphenol A in newborn rats
- B25 HEPATOTOXICITY OF TOCP IN RATS
- EFFECTS OF CONTINUOUS ALCOHOL INGESTION ON LOCOMOTOR ACTIVITY AND EATING BEHAVIOR
- EFFECTS OF ALCOHOL ON SUBACUTE TOXICITY OF PESTICIDES
- RETARDATION OF EPIPHYSEAL CLOSURE OF THE TIBIA AND FEMUR IN RATS FOLLOWING THE CHRONIC ORAL ADMINISTRATION OF ZIRAM
- EFFECTS OF QUERCETIN AND BUTYLATED HYDROXYTOLUENE ON HAMSTERS EXPOSED TO TOBACCO SMOKE
- Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma
- Lack of Modifying Effect of Arctiin on ENU-Induced Uterine Carcinogenesis in ICR Mice
- Cytokeratin 8/18 Is a Useful Immunohistochemical Marker for Hepatocellular Proliferative Lesions in Mice
- Classification of Renal Proliferative Lesions in Rats and/or Mice and Their Diagnostic Problems : Report from the Working Group of the Japanese Society of Toxicologic Pathology
- POSSIBLE MECHANISM ON ENHANCED CARCINOGENESIS OF GENOTOXIC CARCINOGENS AND UNSOLVED MECHANISMS ON LESSER CARCINOGENIC SUSCEPTIBILITY TO SOME CARCINOGENS IN RASH2 MICE
- Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model
- A Neuroendocrine Carcinoma of Undetermined Origin in a Dog
- No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats
- Gene Expression Profiling and Cellular Distribution of Molecules with Altered Expression in the Hippocampal CA1 Region after Developmental Exposure to Anti-Thyroid Agents in Rats
- Preparation and Characterization of Liposomal Microencapsulated Poly-γ-glutamic Acid for Prevention of Ca-Phosphate Precipitation under Intestinal Environment
- Spontaneous Renal Mixed Epithelial and Stromal Tumor (MEST) in a Beagle
- Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action
- Threshold dose of liver tumor promoting effect of β-naphthoflavone in rats
- Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action
- Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats
- Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats
- No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats
- A Case Report of a Renal Mixed Epithelial and Stromal Tumor in a Heterozygous S1P2 Receptor Deficient Mouse(Pathology)
- Induction of ovarian toxicity in a subchronic oral toxicity study of citrinin in female BALB/c mice