A Neuroendocrine Carcinoma of Undetermined Origin in a Dog
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概要
- 論文の詳細を見る
In this report, we describe a case of neuroendocrine carcinoma of undetermined origin in a dog. Necropsy revealed scattered small neoplastic nodules in the bilateral lungs and a small nodule in the parapancreatic lymph node. Histopathologically, both pulmonary and lymph nodal nodules showed a similar histologic pattern, with neoplastic cells being arranged in diffusely proliferating sheet-like cellular nests separated by variable amounts of fibrous septa, sometimes forming rosettes and duct-like structures. Scattered small necrotic foci and invasion to fibrous septa were typically observed. Neoplastic cells showed round to oval-shaped nuclei with prominent nucleoli and abundant eosinophilic cytoplasm that were positive for Grimelius silver impregnation staining and immunostaining with cytokeratin, synaptophysin, vasoactive intestinal peptide and chromogranin A, indicative of the development of a neuroendocrine carcinoma. However, judging from the distribution of tumors lacking the portion suggestive of the primary site in any organ examined, as well as no further indication of differentiation potential of neoplastic cells, this tumor has so far been diagnosed as neuroendocrine carcinoma of undetermined origin.
- 日本毒性病理学会の論文
著者
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SHIBUTANI Makoto
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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MITSUMORI Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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TANIAI Eriko
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Morita Reiko
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Kuwata Kazunori
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Division Of Animal Science Institute Of Symbiotic Science And Tec
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Taniai Eriko
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Shibutani Makoto
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Shibutani Makoto
Division Of Pathology National Institute Of Health Sciences
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Kemmochi Yusuke
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Ogawa Bunichiro
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Morita Reiko
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Kemmochi Yusuke
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Kuwata Kazunori
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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