Absence of DNA Damage in Comet Assay and Liver Initiation Activity of Cinnamaldehyde
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the in vivo genotoxicity of cinnamaldehyde (CNMA) that is present in cigarette smoke, 8 organs and bone marrow of male mice given a single oral administration of 250 or 125 mg/kg body weight of CNMA were evaluated by an alkaline single-cell gel electrophoresis (comet) assay. The liver initiation activity of CNMA was also investigated by a short-term liver initiation assay. PH (Partially hepatectomized) male rats were given 1250 mg/kg body weight of CNMA by a single oral administration 12 hours after partial hepatectomy. In the comet assay, no significant differences of nuclear migration were observed in all tissues examined in mice treated with CNMA at 3 and 24 hours after administration. In the initiation assay, there were no significant increases in areas and numbers of glutathione S-transferase placental form (GST-P) positive foci in the livers of rats treated with CNMA. Based on these results, the possibility that CNMA has in vivo genotoxicity or liver initiation activity appears to be extremely low.
- 日本毒性病理学会の論文
- 2005-03-30
著者
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MITSUMORI Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Mitsumori Kunitoshi
東京大学医科学研究所 癌細胞シグナル分野
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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OKAMURA Miwa
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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WATANABE Takao
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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KASHIDA Yoko
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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MOTO Mitsuyoshi
Laboratory of Veterinary of Pathology, Tokyo University of Agriculture and Technology
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Mitsumori K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Yasuhara Kazuo
Divisions Of Toxicology National Institute Of Hygienic Sciences
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Yasuhara Kazuo
Division Of Pathology National Institute Of Health Sciences
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Muguruma Masako
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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SASAKI Yu
Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National Colle
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Moto Mitsuyoshi
東京農工大学 獣医病理学
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Moto Mitsuyoshi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Muguruma Masako
東京農工大学 獣医病理学
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Muguruma Masako
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Sasaki Yu
八戸工業高等専門学校
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Sasaki Yu
東京農工大学 農学部
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Sasaki Yu
Laboratory Of Genotoxicity Faculty Of Chemical And Biological Engineering Hachinohe National College
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Watanabe Takao
Laboratory Of Veterinary Pathology Faculty Of Agriculture Tokyo University Of Agriculture And Techno
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Kodama Yukio
Division Of Pathology National Institute Of Health Sciences
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Kitamura Y
Division Of Pathology National Institute Of Health Sciences
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Okamura Miwa
東京農工大学 農学部獣医病理学研究室
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安原 加壽雄
San-ei Gen F.f.i. Inc.
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Mitsumori Kunitoshi
Department Of Pathology National Institute Of Health Sciences
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Sasaki Yu
Lab. Of Genotoxicity Fac. Of Chemical And Biological Engineering Hachinohe National Coll. Of Technol
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Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Division Of Animal Science Institute Of Symbiotic Science And Tec
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Kamimura Yasuhiro
Safety Evaluation Lab. Yoshitomi Pharm.
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Yoshikawa Katsunori
Department Of Bioinformatic Engineering Graduate School Of Information Science And Technology Osaka
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Okamura Miwa
Laboratory Of Veterinary Pathology Faculty Of Agriculture Tokyo University Of Agriculture And Techno
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Matsumoto K
Kyushu Univ. Fukuoka Jpn
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Matsumoto K
Drug Safety Research Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.:l
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Kurokawa Y
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Kodama Y
Biological Safety Research Center National Institute Of Health Science
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三森 国敏
Division Of Pathology National Institute Of Health Sciences
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Kuroiwa Yuichi
Division Of Pathology National Institute Of Health Sciences
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Kawasaki Yasushi
National Institute Of Health Sciences
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Kashida Y
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Kurokawa Yuji
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
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Kawasaki Yasushi
Div.of Toxicol. National Institute Of Health Sciences
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Kodama Yukio
Cel. Mol. Tox. Div. Nihs
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Matsumoto K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Watanabe Tomoyuki
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Katakura Yoshio
Department Of Life Science And Bioengineering Faculty Of Chemistry Materials And Bioengineering Kans
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Yasuhara Kazuo
Division Of Toxicology Biological Safety Research Center National Institute Of Hygienic Sciences
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Katakura Yoshio
Department Of Biotechnology Faculty Of Engineering Osaka University
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