Kuroiwa Yuichi | Division Of Pathology National Institute Of Health Sciences
スポンサーリンク
概要
関連著者
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Kitamura Y
Division Of Pathology National Institute Of Health Sciences
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Kodama Yukio
Division Of Pathology National Institute Of Health Sciences
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Yasuhara Kazuo
Division Of Pathology National Institute Of Health Sciences
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KAWASAKI Yasushi
Div of Cellular and Molecular Toxicology
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Umemura T
Division Of Pathology National Institute Of Health Sciences
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Mori H
Division Of Pathology National Institute Of Health Sciences
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UMEMURA Takashi
Division of Pathology, National Institute of Health Sciences
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Yasuhara Kazuo
Divisions Of Toxicology National Institute Of Hygienic Sciences
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Nishikawa Akiyoshi
Division of Pathology, National Institute of Health Sciences
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Hirose Masao
Division of Pathology, National Institute of Health Sciences
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Mitsumori Kunitoshi
東京大学医科学研究所 癌細胞シグナル分野
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Hirose Masao
国立医薬品食品衛生研究所 病理
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Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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INOUE Tohru
Safety and Research Center of National Institute of Health Sciences
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Mitsumori K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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INOUE Tohru
Center for Biological Safety and Research
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MITSUMORI Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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KANKI Keita
Division of Pathology, National Institute of Health Sciences
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Kanki K
Division Of Pathology National Institute Of Health Sciences
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Kanki Keita
国立医薬品食品衛生研究所 病理部
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Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
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Hirose M
Division Of Pathology National Institute Of Health Sciences:food Safety Commission
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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ISHII Yuji
Division of Pathology, National Institute of Health Sciences
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KODAMA Yukio
Division of Toxicology, National Institute of Health Sciences
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Kanki Keita
Division Of Pathology National Institute Of Health Sciences
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KITAMURA Yasuki
Division of Pathology, National Institute of Health Sciences
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HIRABAYASHI Yoko
Division of Cellular and Molecular Toxicology, Kangwon National University
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Nishimura T
Division Of Environmental Chemistry
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Kitajima Satoshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Satoh Kanako
東京都健康安全研究センター 環境保健部
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Sai-kato Kimie
Division Of Toxicology
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Hirabayashi Yoko
Division Of Cellular And Molecular Toxicology Kangwon National University
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IMAZAWA Takayoshi
Division of Pathology, National Institute of Health Sciences
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KASHIDA Yoko
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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YOON Byung-Il
Division of Cellular and Molecular Toxicology, Kangwon National University
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KANEKO Toyozo
Division of Cellular and Molecular Toxicology, Kangwon National University
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Sai Kimie
Divislon Of Toxicology National Institute Of Health Sciences
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Imazawa T
Division Of Pathology National Institute Of Health Sciences
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Imazawa Takayoshi
国立医薬品食品衛生研究所 病理部
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KANEKO Toyozo
National Center for Drug Safety Evaluation
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Sekita Kiyoshi
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Hoshi Manabu
大阪市立大学 医学部病理学
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OKAMURA Miwa
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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KANNO Jun
Division of Cellular and Molecular Toxicology, Kangwon National University
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Satoh Kanako
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Shirao Kuniaki
Gastrointestinal Oncology Division National Cancer Center Hospital
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Hasegawa Ryuichi
National Institute Of Health Sciences
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Hasegawa Ryuichi
Division Of Toxicology National Institute Of Health Sciences
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Watanabe Takao
Laboratory Of Veterinary Pathology Faculty Of Agriculture Tokyo University Of Agriculture And Techno
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KUROIWA Yuichi
Division of Pathology, National Institute of Health Sciences
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NOHMI Takehiko
Division of Genetics and Mutagenesis, National Institute of Health Sciences
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WATANABE Takao
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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MOTO Mitsuyoshi
Laboratory of Veterinary of Pathology, Tokyo University of Agriculture and Technology
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Tasaki Masako
Division Of Pathology National Institute Of Health Sciences
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三森 国敏
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Okazaki K
Toxicology Division Gotemba Laboratory Bozo Research Center Inc.
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Okazaki Kazushi
国立医薬品食品衛生研究所 病理部
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Okazaki Kazushi
Gotemba Laboratory Bozo Research Center Inc.
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Okazaki Kazushi
Division Of Pathology National Institute Of Health Sciences
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Moto Mitsuyoshi
東京農工大学 獣医病理学
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Moto Mitsuyoshi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Muguruma Masako
東京農工大学 獣医病理学
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INOUE Tohru
Division of Toxicology
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KUROKAWA Yuji
Division of Toxicology
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OKAMURA Toshiya
Division of Pathology, National Institute of Health Sciences
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TASAKI Masako
Division of Pathology, National Institute of Health Sciences
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OKAZAKI Kazushi
Division of Pathology, National Institute of Health Sciences
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Muto Tomoko
麻布大学 獣医学部比較毒性学
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武藤 朋子
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Muto Tomoko
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Muto Tomoko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Muto Tomoko
Comparative Toxicology Laboratories Azabu University School Of Veterinary Medicine
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HASEGAWA Ryuichi
Division of Medical Safety Science, National Institute of Health Sciences
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Hirose Masao
名古屋市立大学 医学研究科実験病態病理学
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Okamura Toshiya
Division Of Pathology National Institute Of Health Sciences
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KUROKAWA Yuji
Sasaki Cancer Research Foundation
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Nakamura H
Department Of Analytical Chemistry Hoshi University
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Yodoi Junji
Department Of Biological Responses Institute For Virus Research Kyoto University
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KITAJIMA Satoshi
Division of Cellular and Molecular Toxicology, BSRC, National Institute of Health Sciences
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TAKIZAWA Tamotsu
Division of Pathology, National Institute of Health Sciences
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UMEMURA Takashi
Div. Pathol, Natl. Inst. Hlth. Sci.
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NISHIKAWA Akiyoshi
Div. Pathol, Natl. Inst. Hlth. Sci.
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KANKI Keita
Div. Pathol, Natl. Inst. Hlth. Sci.
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HIROSE Masao
Div. Pathol, Natl. Inst. Hlth. Sci.
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MORI Taeko
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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和久井 信
Department Of Toxicology Azabu University School Of Veterinary Medicine
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NISHIMURA Tetsuji
Division of Environmental Health, National Institute of Health Sciences
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TAMURA Toru
Division of Pathology, National Institute of Health Sciences
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和久井 信
麻布大学 獣医
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Takizawa Tamotsu
東京農工大学
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Takizawa Tamotsu
Division Of Pathology National Institute Of Health
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Takizawa Tamotsu
Division Of Pathology National Institute Of Health Sciences
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Inoue Tomoki
Division of Pathology, National Institute of Health Sciences
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Muguruma Masako
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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KASHIDA Yoko
Tokyo University of Agriculture and Technology
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MITSUMORI Kunitoshi
Tokyo University of Agriculture and Technology
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Tamura Toru
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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LI Guang-Xun
Div of Cellular and Molecular Toxicology
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NAGAO Taku
National Institute of Health Sciences
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Muguruma Masako
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Hasegawa Ryuichi
ボゾリサーチセンター
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Ono Atsushi
Division of Toxicology, National Institute of Health Sciences
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TSUDA Mitsuhiro
Division of Pharmacology, National Institute of Health Sciences
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Sasaki Yu
八戸工業高等専門学校
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Sasaki Yu
東京農工大学 農学部
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Suzuki Yuta
Division of Cardiology Department of Medicine, Keio University School of Medicine
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KANAI Yoshikatsu
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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NAKATSU Noriyuki
Division of Cellular and Molecular Toxicology, BSRC, National Institute of Health Sciences
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AISAKI Ken-ichi
Division of Cellular and Molecular Toxicology, BSRC, National Institute of Health Sciences
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IGARASHI Katsuhide
Division of Cellular and Molecular Toxicology, BSRC, National Institute of Health Sciences
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OGAWA Yukio
Cellular & Molecular Toxicology Division, Biological Safety Research Center, National Institute of H
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SEKITA Kiyoshi
Cellular & Molecular Toxicology Division, Biological Safety Research Center, National Institute of H
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KITAJIMA Satoshi
Cellular & Molecular Toxicology Division, Biological Safety Research Center, National Institute of H
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Imai Toshio
Division of Pathology, National Institute of Health Sciences
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Nakamura Yasushi
Department of Clinical Laboratory Medicine, Wakayama Medical University
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高橋 通正
(独)産業技術総合研究所 環境管理技術研究部門
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鷹橋 浩幸
Department of Pathology, The Jikei University School of Medicine
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鷹橋 浩幸
Dept. Pathol. Jikei Univ. Sch. Med.
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鷹橋 浩幸
麻布大学 獣医
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FURUKAWA Fumio
Division of Pathology, National Institute of Health Sciences
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YOSHIMURA Yoshihiro
Department of Analytical Chemistry, Hoshi University
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MIYAUCHI Makoto
Division of Pathology, National Institute of Health Sciences
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ISHII Yuji
Faculty of Pharmaceutical Science, Department of Analytical Chemistry, Hoshi University
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OKANO Keita
Faculty of Pharmaceutical Science, Department of Analytical Chemistry, Hoshi University
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MARUYAMA Satoshi
Department of Analytical Chemistry, Hoshi University
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YAMAGISHI Megumi
Division of Pathology, National Institute of Health Sciences
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NAKAZAWA Hiroyuki
Department of Analytical Chemistry, Hoshi University
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MASUMURA Ken-ichi
Division of Genetics & Mutagenesis, National Institute of Health Sciences
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ISHII Yuji
Div. Pathol, Natl. Inst. Hlth. Sci.
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KUROIWA Yuichi
Div. Pathol, Natl. Inst. Hlth. Sci.
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NAKAZAWA Hiroyuki
Dep. Anal. Chem., Hoshi Univ.
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IMAZAWA Takayoshi
Department of Pathology, Kangwon National University
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NISHIKAWA Akiyoshi
Department of Pathology, Kangwon National University
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YODOI Junji
Department of Biological Responses, Institute for Virus Research, Kyoto University
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HAN Jeong-Hee
Department of Veterinary Medicine, Kangwon National University
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HIROSE Masao
Department of Pathology, Kangwon National University
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YAMAZAKI Masaki
Laboratory of Veterinary of Pathology, Tokyo University of Agriculture and Technology
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KITAMURA Yasuki
Div. of Pathol.
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IMAZAWA Takayoshi
Div. of Pathol.
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KODAMA Yukio
Toxicol., NIHS
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ITOH Ken
Univ. of Tsukuba
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YAMAMOTO Masayuki
Univ. of Tsukuba
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Hirose Akihiko
National Institute Of Health Sciences
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Hirose Akihiko
National Inst. Of Health Sciences
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MASEGI Toshiaki
Department of Veterinary Pathology, Gifu University
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Yasuhara K
Division Of Pathology National Institute Of Health Sciences
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MARUYAMA Satoshi
Division of Pathology, National Institute of Health Sciences
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SON Hwa-young
Division of Pathology, National Institute of Health Sciences
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LEE Kyong-Youl
Division of Pathology, National Institute of Health Sciences
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MINEMURA Yukie
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Hirose Masao
国立医薬品食品衛生研究所 病理部
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Mitsumori Kunitoshi
杏林製薬研究センター
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Sai Kimie
Div. Of Toxicology Biological Safety Research Center National Institute Of Hygienic Sciences
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OKAMURA Miwa
Tokyo University of Agriculture and Technology
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UNAMI Akira
Astellas Pharma Inc.
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MATSUMOTO Masahiro
Astellas Pharma Inc.
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OISHI Yuji
Astellas Pharma Inc.
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ITOH Tadashi
Tokyo University of Agriculture and Technology
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SASAKI Yu
Hachinohe National College of Technology
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KUMATANI Kiyomi
Hachinohe National College of Technology
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SAKAI Hiroki
Gifu University
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SASAKI Yu
Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National Colle
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Hayashi Y
National Inst. Health Sci. Tokyo
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Hayashi Yuzo
Department Of Pharmaceutical Sciences Kitasato University
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Takahashi M
National Inst. Health Sci. Tokyo
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KAMATA Eiichi
National Institute of Health Sciences
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HIRABAYASHI Yoko
Div of Cellular and Molecular Toxicology
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YODOI Junnji
Dept of Biological Responses, Institute for Virus Research, Kyoto Univ.
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YOON Byung-II
Div of Cellular and Molecular Toxicology
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OKAZAKI SHUZO
Gotemba Lab., Bozo Research Center Inc.
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NAKAMURA HIDEAKI
Gotemba Lab., Bozo Research Center Inc.
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KITAMURA YASUKI
Gotemba Lab., Bozo Research Center Inc.
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HATAYAMA KAZUHISA
Gotemba Lab., Bozo Research Center Inc.
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TSUDA TOSHIHARU
Gotemba Lab., Bozo Research Center Inc.
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KATSUMATA TOMOYOSHI
Gotemba Lab., Bozo Research Center Inc.
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HIOKI Kyoji
Center Institute for Experimental Animals
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NOMURA Tatsuji
Center Institute for Experimental Animals
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OKAZAKI Kazushi
Div.Pathol., Natl.Inst.Health Sci.
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NISHIMURA Susumu
Gotemba Lab., Bozo Research Center Inc.
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NAKAMURA Atushi
Gotemba Lab., Bozo Research Center Inc.
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NISHIKAWA Akiyoshi
Div.Pathol., Natl.Inst.Health Sci.
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HIROSE Masao
Div.Pathol., Natl.Inst.Health Sci.
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TOYOKUNI Shinya
Department of Pathology and Biology of Disease, Graduate School of Medicine, Kyoto University
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UCHIDA Koji
Laboratory of Food and Biodynamics, Nagoya University School of Agriculture
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TAKAGI Atsuya
Div. of Toxicology, National Institute of Health Sciences
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KUROKAWA Yuji
Div. of Toxicology, National Institute of Health Sciences
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Sekita Kiyoshi
Division of Toxicology, National Institute of Health Sciences
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Ogawa Yukio
Division of Toxicology, National Institute of Health Sciences
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Saito Minoru
Division of Toxicology, National Institute of Health Sciences
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Naito Katsushi
Division of Toxicology, National Institute of Health Sciences
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Kawashima Kunio
Division of Toxicology, National Institute of Health Sciences
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SAKEMI Kazue
Division of Pharmacology, National Institute of Health Sciences
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Sasaki Yu
Laboratory Of Genotoxicity Faculty Of Chemical And Biological Engineering Hachinohe National College
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TANAKA Satoru
Toxicology Laboratory, Kissei Pharmaceutical Co., Ltd.
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Furukawa Fumio
Division Of Pathology National Institute Of Health Sciences
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KANNO Jun
Div of Cellular and Molecular Toxicology
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Mori Hideki
岐阜薬科大学 生物薬学研究所
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Kojima Shigeo
Divisions Of Toxicology And Pharmacology National Institute Of Health Sciences
著作論文
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Catechol enhanced mice hepatotoxicity treated with acetaminophen(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
- Electron Microscopical Evidence of the Protective Function of Thioredoxin (TRX/ADF) Transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Cellular Toxicity in the Liver and Brain
- Tumorigenic Susceptibility of Catechol on the Gastric Mucosa in rasH2 Mice
- P8-27 Susceptibility to pentachlorophenol, a mouse liver carcinogen in Nrf2-deficient mice(CIRCULATORY SYSTEM-2/ACTIVE OXYGEN)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-43 Screening of chemopreventive agents using a medium-term pancreas carcinogenesis model in hamsters(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate
- A possible role of oxidative stress in potassium bromate (KBrO_3) carcinogenesis (ACTIVE OXYGEN) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl) nitrosamine
- Modifying Effects of 2,6-Dimethylaniline on Nasal Carcinogenesis in RasH2 Mice Initiated with 4-Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis : Results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
- The expression of Ras-related molecules in DMBA-induced forestomach tumors in rasH2 mice(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- In vitro genotoxic potential and liver initiation activity of ciprofloxacin(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Mechanistic study on hepatocarcinogenesis induced by dicyclanil in mice : possible involvement of oxidative stress(Proceedings of the 32nd Annual Meeting)
- Induction of Hepatocellular Proliferative Lesions in CBA Mice by a 26-week Dietary Administration of Kojic Acid
- Absence of DNA Damage in Comet Assay and Liver Initiation Activity of Cinnamaldehyde
- Enigma of oxidative stress in benzene induced hematotoxicity answered by thioredoxin-overexpression mouse(Blood, Biomarker, Proceedings of the 32nd Annual Meeting)
- The Mouse rasH2/BHT Model as an in vivo Rapid Assay for Lung Carcinogens
- Prevention by 2-Mercaptoethane Sulfonate and N-Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate
- P10-09 A Repeated 28 Days Oral Dose Toxicity Study of Methoxychlor in Rats, Based on the 'Enhanced OECD Test Guideline 407' for Screening Endocrine-disrupting Chemicals.
- Comparison of the early gene responses of Ahr-activating chemicals using the Percellome system(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- The development of Chemical Toxicogenomics Database by the "Percellome" system for the mechanism-based toxicology(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- Toxicity study of Garcinia cambogia extract (3) : Testicular toxicity of Hydroxycitric acid in mice(General toxicity, Proceedings of the 32nd Annual Meeting)
- Bio-molecular model for cancer prevention : Attenuation of oxidative stress by thioredoxin over-expression to reduce the benzene leukemia (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Aryl hydrocarbon receptor (AhR) mediated hematotoxicity induced by benzene.(GENERAL SESSION BY ORAL PRESENTATION)(BLOOD SYSTEM & HEMATOLOGY)
- Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
- Testicular spermiation failure in rats exposed prenatally to 3,3',4,4',5-pentachlorobiphenyl
- Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
- Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver
- CARCINOGENIC SUSCEPTIBILITY OF HRAS2 TRANSGENIC MICE TO VINYL CARBAMATE AND RAS GENE MUTAIONS IN INDUCED LUNG TUMORS
- TOXICITY STUDY OF A RUBBER ANTIOXIDANT, 2-MERCAPTOBENZIMIDAZOLE, BY REPEATED ORAL ADMINISTRATION TO RATS
- P7-35 Three-months dietary toxicity study of o-cymen-5-ol(biosol) in rats : Biosol induced renal injury and thymocyte apoptosis(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Toxicity study of Garcinia canbogia extract I : A 52-week-toxicity study of Garcinia cambogia extract in rats (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- O-17 Analysis of expression profile of circadian genes(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Testicular Toxicology of Pubescent and Adult Rats Prenatally Exposure to 3,3',4,4',5-Pentachlorobiphenyl
- 231 ANALYSIS OF THE NATIONAL TOXICOLOGY PROGRAM DATA ON IN VITRO GENETIC TOXICITY TESTS, OCTANOL/WATER PARTITION COEFFICIENTS AND ACUTE TOXICITY USING MULTIVARIATE STATISTICAL METHOD
- P12-03 Is Nrf2 gene Involved in benzene metabolic pathway?
- O-55 HEMATOTOXICICOLOGIC CHARACTERISTICS FOR OXIDATIVE STRESSES INTRANSGENIC AND/OR KNOCK-OUT MICE FOR THIOREDOXIN/ADF GENE.(Proceedings of the 27th Annual Meeting)
- 21B-10-4 Benzene hemopoietic toxicity revisited- a new concept.
- P10-17 Risk assessment for formaldehyde in drinking water via oral and inhalation exposure.
- Sperm test using CASA (HTM-IVOS) 1. α-chlorohydrin.
- A 14-WEEK ORAL TOXICITY STUDY OF TRIBUTOXYETHYL PHOSPHATE(TBEP) IN RATS
- SENSITIZATION POTENCIES AND CROSS REACTIVITY OF THIOUREADERIVED RUBBER ACCELERATORS IN GUINEA PIGS
- STUDIES ON THE OPTIMAL TREATMENT PERIOD AND PARAMETERS FOR DETECTION OF MALE FERTILITY DISORDER IN RATS : INTRODUCTORY SUMMARY (<SPECIAL ISSUE>TESTICULAR TOXICITY)
- 332 CELL PROLIFERATIVE ACTIVITIES OF CHOLANGIOFIBROSIS IN RATS INDUCED BY BROMODICHLOROMETHANE