Age-Related Hematological Changes in Normal F344 Rats: during the Neonatal Period
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概要
- 論文の詳細を見る
In order to clarify age-related changes in hematological values of normal rats after birth, blood samples from neonatal F344 rats of both sexes were examined periodically during the period from 0 to 40 days postpartum. The erythrocyte count (RBC) increased with time after birth as a function of age. In contrast, the reticulocyte count (Retics) continuously decreased with time after birth. Hemoglobin (Hb), hematocrit (Ht), and the mean corpuscular hemoglobin concentration (MCHC) tended to decrease after birth until weaning (about 21 days postpartum), but they began to increase after weaning. Mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) also gradually decreased after birth until weaning, but they were unchanged thereafter. The platelet count (PLT) gradually increased after birth and reached a plateau at weaning. Microscopic examination of blood smears revealed that erythrocytes at birth had characteristic morphological features such as anisocytosis, polychromasia, basophilic stippling, Howell-Jolly body, and erythroblastosis. These characteristic features, however, disappeared by 30 days after birth. The total leukocyte count (WBC) gradually increased with time after birth, due to an increase in the number of lymphocytes. The lymphocyte count started to rapidly increase within several days after birth and the increase continued thereafter. Other differential leukocyte counts also showed various characteristic patterns of changes during the neonatal period. There were no apparent differences between males and females in these changes in hematological values.
- 社団法人 日本実験動物学会の論文
著者
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
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Kojima Sayuri
The Institute of Environmental Toxicology
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Enomoto Akiko
The Institute of Environmental Toxicology
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Harada Takanori
The Institute of Environmental Toxicology
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Mitsumori Kunitoshi
杏林製薬研究センター
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Maita Keizo
The Institute of Environmental Toxicology
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Haruta Junko
The Institute Of Environmental Toxicology
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Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
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Harada Tomoko
協和醗酵工業
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Harada Tomoko
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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MITSUMORI Kunitoshi
Institute of Environmental Toxicology
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原田 孝則
The Institute of Environmental Toxicology
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FUJISAWA Hideki
The Institute of Environmental Toxicology
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Kojima Sayuri
残留農薬研究所
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Mitsumori K
The Institute Of Environmental Toxicology:agrotox Inc.
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