Response of Respiratory Epithelium of BN and F344 Rats to Formaldehyde Inhalation
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概要
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BN rats are well-known for their high capacity for IgE production and hyperresponsiveness to exposure to allergens or other chemicals. We examined the histological changes in the nasal cavity, trachea and lungs of BN and F344 rats after the inhalation of aerosol formaldehyde (HCHO), which exerts direct toxic effects on the respiratory system. The incidence of clinical signs such as sneezing and abnormal respiration in HCHO-treated F344 rats was higher than that in HCHO-treated BN rats. The mean body weight of HCHO-treated F344 rats apparently decreased in comparison with control F344 rats, but that of HCHO-treated BN rats was not significantly different from that of control BN rats. Changes such as squamous metaplasia, stratification, degeneration and desquamation were observed by light microscopy in nasal, tracheal and bronchial mucosa in the lungs of the HCHO-treated F344 rats. In the HCHO-treated BN rats, similar but milder lesions were restricted to the nasal mucosa. Scanning electron microscopic observation supported these light microscopic observations. These results suggest that BN rats have lower sensitivity to HCHO inhalation than F344 rats.
- 社団法人 日本実験動物学会の論文
- 1997-10-01
著者
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Harada Takanori
The Institute of Environmental Toxicology
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ITAGAKI Shin-ichi
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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Harada Tomoko
協和醗酵工業
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Harada Tomoko
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Ohtsuka Ryoichi
The Institute Of Environmental Toxicology
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大塚 亮一
Institute Of Environmental Toxicology
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Ohtsuka Ryoichi
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Ohtsuka Ryoichi
Department Of Biomedical Science The University Of Tokyo
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Takeda Makio
The Institute of Environmental Toxicology
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Fujie Hideaki
The Institute of Environmental Toxicology
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武田 真記夫
Institute Of Environmental Toxicology
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Takeda M
Kobe-university
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首藤 康文
The Institute of Environmental Toxicology
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武田 真記夫
The Institute of Environmental Toxicology
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SHUTO Yasufumi
The Institute of Environmental Toxicology
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Takeda Makio
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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首藤 康文
岩手大学農学部家畜解剖学教室
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板垣 慎一
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Itagaki Shin-ichi
Department Of Biomedical Science The University Of Tokyo
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Fujie Hideaki
Toxicology Division The Institute Of Environmental Toxicology
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Itagaki Shin-ichi
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Itagaki Shin-ichi
Department Of Biomedical Science Faculty Of Agriculyure The University Of Tokyo
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