Functional and Histochemical Analysis on Pancreatic lslets of APA Hamsters with SZ-Induced Hyperglycemia and Hyperlipidemia
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概要
- 論文の詳細を見る
To clarify how Syrian hamsters of the APA strain (APA hamsters) keep a diabetic condition for a long period, the functional and histochemical changes in the pancreatic islets of diabetic APA hamsters were examined. By glucose tolerance test, no glucose-induced insulin secretion was seen in the diabetic APA hamsters. By immunohistochemistry, it was revealed that at 24 hr after SZ-injection, the number of islets had decreased and that remnant islets had become markedly smaller. The islets had hardly, any insulin-immunoreactive cells and consisted of cells stained by anti-glucagon and somatostatin antibodies. One, three and six months after SZ-injection, a small number of cells with vacuolative changes, which were positive for PAS staining, were observed in most islets and the vacuolated cells were stained mainly by anti-insulin antibody. In addition, a number of PCNA-positive cells were observed, especially in the periphery of the vacuolated cells, while TUNEL-positive cells were not detected. This data suggests that β-cells proliferating as a result of the replication of the resident β-cells in islets had fallen into degeneration and necrosis by a stress, such as the glycogen deposition in hyperglycemia and hyperlipidemia. Consequently, secretion of insulin was maintained at low levels, which allowed the hamsters to live without insulin therapy in the diabetic condition for over 6 months.
- 社団法人 日本実験動物学会の論文
著者
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YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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TAKATORI Atsushi
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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INENAGA Toshiaki
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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HORIUCHI Keiko
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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KAWAMURA Seiji
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, the University
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Yoshikawa Yasuhiro
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Kyuwa S
Univ. Tokyo Tokyo Jpn
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Kyuwa Shigeru
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Kyuwa Shigeru
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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ITAGAKI Shinichi
Department of Biomedical Science, School of Agricultural and Life Sciences, University of Tokyo
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NISHIDA Etsuko
Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo
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Yoshikawa Y
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Horiuchi Keiko
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Kawamura Seiji
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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吉川 泰弘
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Takatori Atsushi
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Inenaga Toshiaki
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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板垣 慎一
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Itagaki Shin-ichi
Department Of Biomedical Science The University Of Tokyo
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Kyuwa Shigeru
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences University Of Tok
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Kyuwa Shigeru
Center For Experimental Medicine Institute Of Medical Science The University Of Tokyo
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Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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吉川 泰弘
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Nishida Etsuko
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Itagaki Shin-ichi
Department Of Biomedical Science Faculty Of Agriculyure The University Of Tokyo
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吉川 泰弘
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Kawamura Seiji
Department Of Biomedical Science Faculty Of Agriculture And Life Sciences University Of Tokyo
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Itagaki Shinichi
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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KAWAMURA Seiji
Department of Agriculture, The University of Tokyo
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