Possible Role of Peripheral CD14^<low> Monocytes in the Development of Collagen-Induced Arthritis in Cynomolgus Monkeys (Macaca fascicularis)
スポンサーリンク
概要
- 論文の詳細を見る
The changes in levels of peripheral major lymphocyte subsets were monitored with 10 adult cynomolgus monkeys (5 females and 5 males) during the 9 weeks after immunization with chick type-II collagen in Freunds complete adjuvant. Three females and 3 males developed overt arthritis determined by swelling of small joints and increase of plasma alkaline phosphatase as well as C-reactive protein. An increase of CD16+ NK cells was observed in four non-arthritis-developed monkeys (two females and two males). There was no significant difference in the fluctuation pattern of CD4+ T cell, CD8+ T cell and CD20+ B cell levels between arthritis-developed monkeys and non-developed ones. In addition, the percentages of CD45RA + CD4+ T cells to total CD4+ T cells, CD28- CD8+ T cells to total CD8+ T cells, and IgD- B cells to total B cells did not significantly differ between them. On the other hand, a significant increase was demonstrated in CD14-positive cells at 3 weeks after immunization in only arthritis-developed monkeys regardless of sex. The expression of CD14 antigen on the surface of increased cells was low in comparison with those appearing in blood obtained before immunization. In addition, increased CD14low cells showed no response to LPS stimulation. However, there was no significant difference in antibody titer to both chick type-II and monkey type-II collagen between arthritis-developed monkeys and non-developed ones. These results suggest that an increase in number of CD14low monocytes with immature function might be a part of the autoimmune response, and that the appearance of these cells is of pathogenic importance in the arthritic process in cynomolgus monkeys regardless of the production of autoantibody.
著者
-
Terao Keiji
Tsukuba Primate Center, National Institute of Infectious Diseases
-
Nagai Yutaka
Koken Bioscience Institute
-
Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
-
Terao Keiji
Tsukuba Primate Center National Institute Of Infectious Diseases
-
Terao Keiji
Tsukuba Primate Center For Medi.sci. Nation.inst.health
-
FUJIMOTO Koji
The Corporation for Production and Research of Laboratory Primates
-
SHIMOZURU Yasunori
Tsukuba Research Laboratory, Eisai Company Ltd
-
Shimozuru Yasunori
Tsukuba Research Laboratory Eisai Company Ltd
-
Nagai Yutaka
Koken Bioscience Institute Koken Company Ltd.
関連論文
- カニクイザルの網膜における黄斑および周辺網膜の比較プロテオミクス
- Retroperitoneal Fibromatosis in a Cynomolgus Monkey (Macaca fascicularis)
- ストレプトゾトシン誘発糖尿病APAハムスターの大動脈における小胞体ストレス
- Astroglial responses against Aβ initially occur in cerebral primary cortical cultures : species differences between rat and cynomolgus monkey
- Immunohistochemical Analysis of Protein Gene Product 9.5, a Ubiquitin Carboxyl-terminal Hydrolase, during Placental and Embryonic Development in the Mouse
- Protective Effects of Probucol Treatment on Pancreatic β-cell Function of SZ-induced Diabetic APA Hamsters
- Characterization of the Testis in Congenitally Ubiquitin Carboxy-Terminal Hydrolase-1 (Uch-L1) Defective (gad) Mice
- The Effect of Probucol on Atherosclerosis in Streptozotocin-Induced Diabetic-Hyperlipidemic APA Hamsters in Different Stages of Atherosclerosis
- PJ-369 Few Transplanted Bone Marrow CD34^+ Cells Become Endothelial and Myocardial Cells in Ischemic Myocardium in Nonhuman Primates(Angiogenesis 3 (IHD) : PJ62)(Poster Session (Japanese))
- Histopathological Studies of Aortic Dissection in Streptozotocin-Induced Diabetic APA Hamsters
- Presenilin-2 in the cynomolgus monkey brain : investigation of age-related changes
- Comparative Study on Toxicokinetics of Bisphenol A in F344 Rats, Monkeys (Macaca fascicularis), and Chimpanzees (Pan troglodytes)
- Molecular Evolution Inferred from Immunological Cross-reactivity of Immunoglobulin G among Chiroptera and Closely Related Species
- Spontaneous T-cell-rich B-cell Lymphoma in a Cynomolgus Monkey (Macaca fascicularis)
- Squamous Cell Carinoma of the Oral Cavity in an Infant Cynomolgus Monkey
- Ratio of Leptin to Adiponectin as an Obesity Index of Cynomolgus Monkeys : Macaca Fascicularis
- Relationship between Body Weight and Hematological and Serum Biochemical Parameters in Female Cynomolgus Monkeys (Macaca fascicularis)
- Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys
- The Region-Specific Functions of Two Ubiquitin C-Terminal Hydrolase Isozymes along the Epididymis
- No Regional Differences of Cytochrome P450 Expression in the Liver of Cynomolgus Monkeys (Macaca fascicularis)
- D-Galactosamine Induced Hepatocyte Apoptosis is Inhabited in vivo and in Cell Culture by a Calcium Calmodulin Antagonist, Chlorpromazine, and a Calcium Channel Blocker, Verapamil
- Renal Function Tests on Diabetes-Induced and Non-Induced APA Hamsters
- Analysis of cDNA Coding MHC Class II β Chain of The Chimpanzee (Pan troglodytes)
- Expression of Lipoprotein Receptors in the Aortic Walls of Diabetic APA hamsters
- Functional and Histochemical Analysis on Pancreatic lslets of APA Hamsters with SZ-Induced Hyperglycemia and Hyperlipidemia
- APA Hamster Model for Diabetic Atherosclerosis. 2. Analysis of Lipids and Lipoproteins
- Aortic Atheromatous Lesions Developed in APA Hamsters with Streptozotocin induced Diabetes: A New Animal Model for Diabetic Atherosclerosis. 1. Histopathological Studies
- Localization and Age-Related Changes in Cytochrome P450 Expression in APA Hamster Livers
- Histopathology of Natural Ebola Virus Subtype Reston Infection in Cynomolgus Macaques during the Philippine Outbreak in 1996
- Chronological and Spatial Analysis of the 1996 Ebola Reston Virus Outbreak in a Monkey Breeding Facility in the Philippines
- Differences between BALB/c and C57BL/6 Mice in Mouse Hepatitis Virus Replication in Primary Hepatocyte Culture
- Sendai Virus Vecto-mediated Gene Transfer of Glial Cell Line-Derived Nertotrophic Factor Prevents Delayed Neuronal Death after Transient Global Ischemia in Gerbils
- ユビキチンのC末端加水分解酵素欠損は骨石灰化を減少させる(生理学)
- Safe And Efficient Collection of Cytokine-Mobilized Peripheral Blood Cells From Cynomolgus Monkeys (Macaca fascicularis) with Human Newborn-Equivalent Body Weights
- Changes in mRNA Expression in Mouse Postnatal Cochlea by Differential Display Method
- Infection of an HIV-1/SIVmac Chimeric Virus Having HIV-1 env to Macaque Monkeys via the Vaginal Cavity
- Cryopreservation of Brain Tissue for Primary Culture
- Effective Delivery of a Lipophilic 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) into Rat Lymphoid Tissues
- Development of an Immunofluorescence Method for the Detection of Antibodies to Ebola Virus Subtype Reston by the Use of Recombinant Nucleoprotein-Expressing HeLa Cells
- INVESTIGATION OF THE MECHANISM OF DRUG-INDUCED AUTOIMMUNE HEMOLYTIC ANEMIA IN CYNOMOLGUS MONKEYS ELICITED BY A REPEATED-DOSE OF A HUMANIZED MONOCLONAL ANTIBODY DRUG
- Distribution of U5 Antigen on Lymphocyte Subsets in Human and Nonhuman Primates
- Chromosome Sorting of Primates : Isolation and Identification of Y Chromosome in Green Monkeys
- Opportunistic Pneumocystis carinii Infection in Red-Bellied Tamarins (Saguinus Iabiatus)
- Possible Role of Genetic Factor(s) on Age-related Increase of Peripheral CD4^+CD^+8 Double Positive T Cells in Cynomolgus Monkeys
- Peripheral blood extrathymic CD4^+CD8^+ T cells with high cytotoxic activity are from the same lineage as CD^+CD8^- T cells in cynomolgus monkeys
- Age-Related Changes in Major Lymphocyte Subsets in Cynomolgus Monkeys
- Comparative Analysis of Human and Macaque Monkey CD4: Differences in Formaldehyde Lability and Conformation
- Peripheral blood CD4^+CD8^+ lymphocytes in cynomolgus monkeys are of resting memory T lineage
- Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis
- Horizontal Transmission of Toxoplasma gondii in Squirrel Monkeys (Saimiri sciureus)
- Molecular Cloning of ELOVL4 Gene from Cynomolgus Monkey (Masasa fascicularis)
- Upgrading of Flow Cytometric Analysis for Absolute Counts, Cytokines and Other Antigenic Molecules of Cynomolgus Monkeys (Macaca fascicularis) by Using Anti-Human Cross-Reactive Antibodies
- COMPARISON BETWEEN DENSITY GRADIENT CENTRIFUGAL METHOD AND WHOLE BLOOD METHOD FOR LYMPHOCYTE SURFACE MARKER ANALYSIS WITH FLOW-CYTOMETRY IN RHESUS MONKEYS
- Establishment of Two Substrains, Diabetes-Prone and Non-Diabetic, from Long-Evans Tokushima Lean (LETL) Rats
- MONITORING OF GENE EXPRESSION IN DIFFERENTIATION OF EMBRYOID BODIES FROM CYNOMOLGUS MONKEY EMBRYONIC STEM CELLS IN THE PRESENCE OF BISPHENOL A
- Essentials for starting a pediatric clinical study (3) : Dynamic changes in early development of immune system in macaque monkeys : The significance from standpoint of preclinical toxicity test using nonhuman primates
- Strategies for Tolerance Induction against Xenogeneic-Gene-Transduced Hematopoietic Stem Cells and Their Selective Expansion in a Monkey Model
- STANDARDIZATION OF DENSITY GRADIENT CENTRIFUGAL METHOD FOR LYMPHOCYTE SURFACE MARKER ANALYSIS WITH FLOW-CYTOMETRY IN CYNOMOLGUS MONKEYS.
- Behavioral evidence of color vision deficiency in a protanomalia chimpanzee (Pan troglodytes)
- Polymorphic variations in long- and middle-wavelength-sensitive opsin gene loci in crab-eating monkeys
- The Repeated Procedure of Weaning and Peer Group Formation Causes Accumulation of Stress and Changes of Plasma Cortisol Level and Natural Killer Activity in Squirrel Monkeys (Saimiri sciureus)
- Familial early onset macular degeneration in cynomolgus monkeys (Macaca fascicularis)
- Osteolytic and osteosclerotic lesion in the femur associated with pustulosis palmaris plantaris
- Locking of the thumb in a patient with de Quervain's disease : a case report
- Submicroscopic Morphology of the Laser Induced Surface Structure of Partially Renatured Gelatin Films
- Submicroscopic Morphological Changes of Laser Induced Surface Structure of Collagen, Tendon, and Gelatin Films
- カニクイザル(Macaca fascicularis)の大規模コロニーにおけるメスの繁殖特性
- Senile Plaques in an Aged Western Lowland Gorilla
- Simple Method for Assaying Serum Oxytocin and Changes of Serum Oxytocin Level during Parturition in Cynomolgus Monkeys
- Possible Role of Peripheral CD14^ Monocytes in the Development of Collagen-Induced Arthritis in Cynomolgus Monkeys (Macaca fascicularis)
- Non-human Primate Model in New Field of Immunology, Psychoneuro-Immunology : Significance for Assessment of Environment Enrichment and Psychological Well-being
- White matter activated glial cells produce BDNF in a stroke model of monkeys
- マウスノロウイルスS7株に対する特異抗体を検出するための間接ELISA法および間接蛍光抗体法
- Detection of B Virus Infection in Cynomolgus Monkeys by ELISA Using Simian Agent 8 as Alternative Antigen
- Molecular Cloning and Expression Analysis of the Bat Toll-Like Receptor 3,7, and 9
- Molecular Cloning and Sequencing of the cDNAs Encoding the Bat Interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12p40, and Tumor Necrosis Factor-Alpha
- Development of a microsatellite marker set applicable to genome-wide screening of cynomolgus monkeys (Macaca fascicularis)
- Direct Experimental Occlusion of the Distal Middle Cerebral Artery Induces High Reproducibility of Brain Ischemia in Mice