Age-Related Changes in Major Lymphocyte Subsets in Cynomolgus Monkeys
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概要
- 論文の詳細を見る
Age-related changes in major lymphocyte subsets were analyzed in 195 cynomolgus monkeys (Macaca fascicularis) aged from one month to 31 years. The percentages of CD20+ B cells in peripheral blood lymphocytes (PBL) decreased with age to five years of age, but after that, no significant change was observed. The percentages of CD16+ NK cells gradually increased during the first five years and reached the peak at from four to ten years of age, whereas the percentages of CD3+ T cells in PBL were relatively constant throughout the life. Among the T cells, the CD4+ CD8- T cells decreased, but CD4- CD8+ T cells increased within the first decade of life. We further analyzed the expressions of CD28 and CD29 molecules on T cells to determine the relation between age-related activation and phenotypic changes. Almost all CD4+ CD8- T cells (>90%) were CD28+ at all ages analyzed, but a clear age-related decrease in CD28 expression was demonstrated in CD4- CD8+ T cells during the first ten years. In the case of CD29 expression, age-related increases in CD29hi cells were apparent in both CD4 + CD8- and CD4- CD8+ T cells during the first ten years. The percentages of CD29hi cells, however, were higher in CD4- CD8+ T cells than in CD4+ CD8- T cells in all ages analyzed. These results indicated that the age-related changes in percentages of major lymphocyte subsets as well as in phenotypes of T cells might be related to the maturation of the immune system including an increase in memory cells in cynomolgus monkeys.
- 社団法人 日本実験動物学会の論文
著者
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YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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Akari Hirofumi
Tsukuba Primate Research Center, National Institute of Biomedical Innovation
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Terao Keiji
Tsukuba Primate Center, National Institute of Infectious Diseases
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ITAGAKI Shinichi
Department of Biomedical Science, School of Agricultural and Life Sciences, University of Tokyo
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Yoshikawa Y
Department Of Biomedical Science The Graduate School Of Agricultural And Life Sciences The Universit
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Akari H
Department Of Virology School Of Medicine University Of Tokushima
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Akari H
徳島大学医学部
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Nam Ki-hoan
Tsukuba Primate Center National Institute Of Infectious Diseases
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Nam Ki-hoan
Iclas Monitoring Subcenter Korea Korea Res. Inst. Of Bioscience And Biotechnology
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Akari Hirofumi
Tsukuba Primate Center For Medical Science National Institute Of Health
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Yoshikawa Yasuhiro
Department Of Biomedical Science The Graduate School Of Agricultural And Life Sciences The Universit
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Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Terao K
National Inst. Infectious Diseases Ibaraki Jpn
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Terao Keiji
Tsukuba Primate Center National Institute Of Infectious Diseases
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Terao Keiji
Tsukuba Primate Center For Medi.sci. Nation.inst.health
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Terao K
Tsukuba Primate Center National Institute Of Infectious Diseases
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Terao Kenichi
Department Of Microbiology And Immunology Tokyo Metropolitan Institute For Neuroscience (tmin)
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Itagaki Shinichi
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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