Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on an ARC/AIDS Rhesus macaque (Macaca mulatta) Infected with Simian Immunodeficiency Virus
スポンサーリンク
概要
- 論文の詳細を見る
The efficacy of 6-chloro-2,3-dideoxyguanosine (6-Cl-ddG) was investigated in vivo by using a male ARC/AIDS rhesus macaque infected with simian immunodeficiency virus (SIVmac251/32H). He was administered subcutaneously 6-Cl-ddG (50 mg/kg B.W.) every 8 hr for 14 days when he showed clinical features of recurrent weight loss, severe diarrhea and neuropathy. The number of CD4+, CD8+ cells and total T cells increased rapidly after administration of 6-Cl-ddG and a high level was maintained for 2 months, but the B cell count decreased during the treatment. The antibody titer to SIV did not change significantly during or after the treatment, but the virus load in the plasma measured by RT-PCR dropped to one-third at the start of the 6-Cl-ddG treatment. Within 3 days after the start of 6-Cl-ddG administration, he began to show recovery in clinical signs including weight increase, and disappearance of diarrhea and neuropathy. These findings suggested that 6-Cl-ddG was effective at the stage of ARC/AIDS in a rhesus monkey infected with SIV.
- 社団法人 日本実験動物学会の論文
著者
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Akari Hirofumi
Tsukuba Primate Research Center, National Institute of Biomedical Innovation
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YOSHIKAWA Yasuhiro
Tsukuba Primate Center, National Institute of Infectious Diseases
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Yoshikawa Y
Department Of Biomedical Science The Graduate School Of Agricultural And Life Sciences The Universit
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Akari H
Department Of Virology School Of Medicine University Of Tokushima
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Akari H
徳島大学医学部
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FUJII Yuji
Iwakuni Research Laboratory, Nippon Paper Industries Co., Ltd.
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MACHIDA Makoto
Iwakuni Research Laboratory, Nippon Paper Industries Co., Ltd.
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Akari Hirofumi
Tsukuba Primate Center For Medical Science National Institute Of Health
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MUKAI Ryouzaburou
Tsukuba Primate Center for Medical Science, National Institute of Health
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MURAYAMA Yuichi
Institute of Basic Medical Sciences, University of Tsukuba
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MORI Kazuyasu
Tsukuba Primate Center for Medical Science, National Institute of Health
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TAKASAKA Masao
Tsukuba Primate Center for Medical Science, National Institute of Health
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MURAKAMI Kunichka
Iwakuni Research Laboratory of Technology, Nippon Paper Industries Co., Ltd.
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Murayama Yuichi
Institute Of Basic Medical Sciences The University Of Tsukuba
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Yoshikawa Yasuhiro
Department Of Biomedical Science The Graduate School Of Agricultural And Life Sciences The Universit
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Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture University Of Tokyo
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Fujii Y
Hamamatsu University School Of Medicine
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Fujii Yuji
Iwakuni Research Laboratory Nippon Paper Industries Co. Ltd.
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Mori K
Tsukuba Primate Center For Medical Science National Institute Of Health
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Takasaka Masao
Tsukuba Primate Center For Medical Science National Institute Of Health
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Machida Makoto
Iwakuni Research Laboratory Nippon Paper Industries Co. Ltd.
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Yoshikawa Yasuhiro
Tsukuba Primate Center
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Fujii Y
Hamamatsu Univ. School Of Medicine Hamamatsu Jpn
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Murakami Kunichka
Iwakuni Research Laboratory Nippon Paper Industries Co. Ltd.
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Mukai Ryouzaburou
Tsukuba Primate Center For Medical Science National Institute Of Health
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