Peripheral Blood CD4 and CD8 Double-Positive T Cells of Rhesus Macaques Become Vulnerable to Simian Immunodeficiency Virus by In Vitro Stimulation Due to the Induction of CCR5
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概要
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In vivo Simian Immunodeficiency Virus (SIV) challenge of macaques demonstrated the earlier disappearance of CD4 and CD8 double-positive (DP) T cells than CD4 single-positive T cells, although its mechanism remains unclear. Here we found that peripheral DP T cells were readily induced to express CCR5, a secondary receptor for SIV, by in vitro stimulation with either concanavalin A or anti-CD3/CD28 monoclonal antibodies. Activated DP T cells were more vulnerable to SIV infection, indicating that the ability of DP T cells to readily express CCR5 after activation may hasten DP T cell death by SIV infection in vivo.
著者
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Matsumoto Yusuke
Department of Veterinary Microbiology, University of Miyazaki
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Miura Tomoyuki
Laboratory of Primate Model, Experimental Research Center for Infectious Disease, Institute for Viru
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Akari Hirofumi
Tsukuba Primate Research Center, National Institute of Biomedical Innovation
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GOTO Yoshitaka
Department of Veterinary Microbiology, University of Miyazaki
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HAGA Takeshi
Department of Veterinary Microbiology, University of Miyazaki
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Miura Tomoyuki
Laboratory Of Viral Pathogenesis Institute For Virus Research Kyoto University
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Miura Tomoyuki
Laboratory Of Pathogenic Virus Institute For Virus Research Kyoto University
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Akari Hirofumi
Tsukuba Primate Center For Medical Science National Institute Of Health
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Haga Takeshi
Department Of Veterinary Microbiology Miyazaki University
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Miura Tomoyuki
Laboratory Of Primate Model Experimental Research Center For Infectious Disease Institute For Virus
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Goto Yoshitaka
Department Of Applied Chemistry Faculty Of Engineering Oita University
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Matsumoto Yusuke
Department Of Surgery National Defense Medical College
関連論文
- Peripheral Blood CD4 and CD8 Double-Positive T Cells of Rhesus Macaques Become Vulnerable to Simian Immunodeficiency Virus by In Vitro Stimulation Due to the Induction of CCR5
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