Horizontal Transmission of Toxoplasma gondii in Squirrel Monkeys (Saimiri sciureus)
スポンサーリンク
概要
- 論文の詳細を見る
The possibility of horizontal transmission of T. gondii was examined in squirrel monkeys. After three monkeys were inoculated perorally with 1.1-2.1 × 103 cysts of the T. gondii ME49, the animals were divided into two cages and maintained with one normal monkey for each cage as a cagemate. Two out of the three T. gondii-inoculated monkeys died, and the remaining one monkey was sacrificed in a moribund state one week after infection because of acute toxoplasmosis. Many T. gondii tachyzoites were recovered from broncho-alveolar lavages and were also found histopathologically in the lung, liver, spleen, kidney and lymph nodes and impression smears of tissues from the three T. gondii-inoculated monkeys by Giemsa staining. Anti-T. gondii antibody was examined by immunoblot assay in these animals, and the antibody to T. gondii major surface membrane protein (p30) could be detected after the start of experiment. Furthermore, a specific band of T. gondii NTPase gene was observed by PCR in the liver and lung of infected and cagemate monkeys, and the sequence of the second PCR products obtained from the cagemates, which were clinically normal but gave a positive result in immunoblotting assay, was exactly the same as the sequence of the NTPase gene of T. gondii ME49. These findings suggested that transmission of T. gondii from the infected monkeys to cagemates occurred easily, and since many T. gondii tachyzoites were recovered from the broncho-alveolar lavages of the three T. gondii-inoculated monkeys, we suggest that aerosol infection plays an important role for the enzootic toxoplasmosis in colonies of squirrel monkeys.
- 社団法人 日本実験動物学会の論文
著者
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YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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UNE Yumi
Department of Pathology, School of Veterinary Medicine, Azabu University
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Yoshikawa Y
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Yoshikawa Yasuhiro
Department Of Biomedical Science Graduate School Of Agricultural And Life Science University Of Toky
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NOMURA Yasuo
Department of Beast Surgery, National Kyushu Cancer Center Hospital, Co-chief Investigator of the Ni
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吉川 泰弘
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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FURUTA Takahisa
Devision of Infections Genetics, Department of Microbiology and Immunology, The Institute of Medical
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OMURA Mizuho
Department of Pathology, School of Veterinary Medicine, Azabu University
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MATSUTANI Noriko
Department of Pathology, School of Veterinary Medicine, Azabu University
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KIKUCHI Takane
Devision of Infections Genetics, Department of Microbiology and Immunology, The Institute of Medical
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HATTORI Shosaku
Amami Laboratory of Injurious Animals, The Institute of Medical Science, The University of Tokyo
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Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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吉川 泰弘
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Omura Mizuho
Department Of Pathology School Of Veterinary Medicine Azabu University
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Nomura Yasuo
Department Of Beast Surgery National Kyushu Cancer Center Hospital Co-chief Investigator Of The Nish
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Nomura Y
Laboratory Of Veterinary Pathology Azabu University
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Kikuchi T
Division Of Infectious Genetics Department Of Microbiology And Immunology Institute Of Medical Scien
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Furuta T
Division Of Infectious Genetics Department Of Microbiology And Immunology Institute Of Medical Scien
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Hattori Shosaku
Amami Laboratory Of Injurious Animals The Institute Of Medical Science The University Of Tokyo
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Hattori Shosaku
Amami Branch Laboratory Institute Of Medical Science The University Of Tokyo
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Matsutani Noriko
Department Of Pathology School Of Veterinary Medicine Azabu University
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