Histopathology of Natural Ebola Virus Subtype Reston Infection in Cynomolgus Macaques during the Philippine Outbreak in 1996
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the livers, spleens, kidneys and lungs collected from 24 cynomolgus macaques (Macaca fascicularis) naturally infected with Ebola virus subtype Reston (EBO-R) during the Philippine outbreak in 1996, in order to reveal the histopathologic findings. These macaques showed necrotic hepatocytes with inclusions, slight to massive fibrin deposition in splenic cords, depletion of lymphoid cells in the white pulp of the spleen, and fibrin thrombi in some organs. Immunohistochemical analysis using anti-leukocyte antigen L1 antibody revealed an increase in blood-derived macrophages/monocytes in the livers, kidneys and lungs of EBO-R infected macaques. EBO-R NP antigens were detected in the macrophages/monocytes, endothelial cells and fibroblasts in the liver, spleen, kidney and lung. These results indicate that EBO-R infection is characterized by systemic coagulopathy and an increase in blood-derived macrophages/monocytes in accordance with the EBO-R propagation in macrophages/monocytes.
- 2002-10-01
著者
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吉川 泰弘
東京大学 大学院農学生命科学研究科実験動物学教室
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YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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UNE Yumi
Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University
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Yoshikawa Yasuhiro
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Miranda Mary
Veterinary Research Department Research Institute For Tropical Medicine
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Yoshikawa Y
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Yoshikawa Yasuhiro
Department Of Biomedical Science Graduate School Of Agricultural And Life Science University Of Toky
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CALAOR Alan
Veterinary Research Department, Research Institute for Tropical Medicine
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MIRANDA Noel
INA Research Philippines, Inc.
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KSIAZEK Thomas
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control an
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IKEGAMI Tetsuro
Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases
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MANARO Daria
Veterinary Research Department, Research Institute for Tropical Medicine, Department of Health
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NIIKURA Masahiro
Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases
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SAIJO Masayuki
Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases
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NOMURA Yasuo
Laboratory of Veterinary Pathology, Azabu University
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KURANE Ichiro
Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases
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MORIKAWA Shigeru
Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases
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Kurane Ichiro
Special Pathogens Laboratory Department Of Virology 1 National Institute Of Infectious Diseases
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吉川 泰弘
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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SAIJO Masayuki
National Institute of Infectious Diseases
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Morikawa Shigeru
Special Pathogens Laboratory Department Of Virology 1 National Institute Of Infectious Diseases
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Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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吉川 泰弘
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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NIIKURA Masahiro
Department of Epizootiology, Faculty of Veterinary Medicine, Hokkaido University
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Une Yumi
Laboratory Of Veterinary Pathology School Of Veterinary Medicine Azabu University
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Miranda Noel
Ina Research Philippines Inc.
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Calaor Alan
Veterinary Research Department Research Institute For Tropical Medicine
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Nomura Y
Laboratory Of Veterinary Pathology Azabu University
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Manalo Daria
Veterinary Research Department Research Institute For Tropical Medicine
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Manaro Daria
Veterinary Research Department Research Institute For Tropical Medicine Department Of Health
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Saijo M
National Inst. Of Infectious Diseases Tokyo Jpn
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Ksiazek Thomas
Special Pathogens Branch Division Of Viral And Rickettsial Diseases Centers For Disease Control And
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吉川 泰弘
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Ikegami Tetsuro
Special Pathogens Laboratory Department Of Virology 1 National Institute Of Infectious Diseases
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Ksiazek Thomas
Special Pathogens Branch Division Of Viral And Rickettsial Diseases Centers For Disease Control And
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Niikura Masahiro
Special Pathogens Laboratory Department Of Virology 1 National Institute Of Infectious Diseases
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Une Yumi
Laboratory Of Veterinary Pathology Azabu University
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