Characterization of the Testis in Congenitally Ubiquitin Carboxy-Terminal Hydrolase-1 (Uch-L1) Defective (gad) Mice
スポンサーリンク
概要
- 論文の詳細を見る
The gracile axonal dystrophy (gad) mice are known to have a deletion within the gene encoding ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) and show hereditary sensory deterioration and motor paresis. Expression of Uch-L1 is reported to be almost limited to the nervous system and testis. To understand whether Uch-L1, one of the major ubiquitin carboxy-terminal hydrolase (UCH) isozymes in the testis, affects spermatogenesis and other UCH isozymes (Uch-L3, L4 and L5) expression in the testis, we compared the testis between gad, hetero and wild type mice by histological, immunohistochemical analyses and RT-PCR. Histological analysis in 25-week-old gad mice showed shrinking of seminiferous tubules, decreasing total number of cells and enlargement of remaining cells in seminiferous tubules. By immunohistochemistry, a significant decrease (p<0.05) in the number of proliferating cell nuclear antigen (PCNA) positive cells was observed. Expression of other UCH isozyme mRNAs was not apparently affected by Uch-L1 deficiency in 25-week-old gad mice. This study is the first report on the testis of gad mutant mouse.
- 社団法人 日本実験動物学会の論文
- 2003-01-01
著者
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吉川 泰弘
東京大学 大学院農学生命科学研究科実験動物学教室
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ISHII Yoshiyuki
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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KYUWA Shigeru
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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KIKUCHI Tateki
Department of Animal Models for Human Disease, National Institute of Neuroscience, NCNP
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Kikuchi Tateki
Department Of Animal Husbandry Faculty Of Agriculture Tohoku University
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Ishii Yoshiyuki
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Ishii Yoshiyuki
東京大学 農生命科研究
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KWON Jungkee
Department of Biomedical Science Graduate School of Agricultural and Life Sciences, The University o
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SETUIE Rieko
Department of Animal Models for Human Disease, National Institute of Neuroscience, National Center o
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Setsuie Rieko
Department Of Animal Models For Human Disease National Institute Of Neuroscience National Center Of
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Ishii Yoshiyuki
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Yoshikawa Yasuhiro
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Kyuwa S
Univ. Tokyo Tokyo Jpn
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Kyuwa Shigeru
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Yoshikawa Y
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Yoshikawa Yasuhiro
Department Of Biomedical Science Graduate School Of Agricultural And Life Science University Of Toky
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Ishii Y
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Ishii Yoshiyuki
Department Of Applied Chemistry Faculty Of Engineering Kyushu Institute Of Technology
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Kwon Jungkee
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Kwon Jungkee
Department Of Laboratory Animal Medicine College Of Veterinary Medicine Chonbuk National University
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Kikuchi Tateki
Department Of Animal Models For Human Disease National Institute Of Neuroscience National Center Of
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Kyuwa Shigeru
Department Of Animal Pathology Institute Of Medical Science University Of Tokyo
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吉川 泰弘
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Kyuwa Shigeru
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences University Of Tok
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Kyuwa Shigeru
Center For Experimental Medicine Institute Of Medical Science The University Of Tokyo
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Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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吉川 泰弘
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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吉川 泰弘
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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