Ratio of Leptin to Adiponectin as an Obesity Index of Cynomolgus Monkeys : Macaca Fascicularis
スポンサーリンク
概要
- 論文の詳細を見る
Obesity is responsible for inducing various metabolic diseases. Laboratory-bred cynomolgus monkeys exhibit spontaneous onset of obesity. However, to date, no blood chemistry index to identify the state of obesity in cynomolgus monkeys has been determined. In the present study, to determine such an index, we measured the serum levels of two adipocyte-derived hormones, leptin and adiponectin, and evaluated the relationship between these hormones and other serum energy metabolic factors (i.e. insulin, total protein, glucose, total cholesterol and triglyceride) as well as the percentage of body fat (%Fat) in mature cynomolgus monkeys. Both in females and males, leptin was positively correlated with insulin and %Fat, and adiponectin was negatively correlated with insulin and %Fat. In female cynomolgus monkeys, leptin, adiponectin, and glucose were selected as the most important determinants for %Fat in multiple regression analysis, and in male cynomolgus monkeys, leptin was selected. The ratio of leptin to adiponectin (L/A ratio) was significantly elevated in the animals with %Fat over 40 (P<0.01). The results indicate that L/A ratio is a potential index for comprehensively identifying obesity in cynomolgus monkeys.
- 社団法人 日本実験動物学会の論文
- 2003-04-01
著者
-
YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
-
Yoshikawa Y
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences Universtiy Of Tok
-
SHEN Yang
Tsukuba Primte Center, National Institute of Infections Diseases
-
OGAWA Hiromi
The Corporation for Production and Research of Laboratory Primates
-
NARITA Hayato
The Corporation for Production and Research of Laboratory Primates
-
OHTOH Keiko
The Corporation for Production and Research of Laboratory Primates
-
YOSHIDA Takashi
Tsukuba Primte Center, National Institute of Infections Diseases
-
Chen Yang
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases:seiwa Pharmaceu
-
Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
-
Shen Yang
Tsukuba Primte Center National Institute Of Infections Diseases
-
Ohtoh K
The Corporation For Production And Research Of Laboratory Primates
-
Yoshida Takashi
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases
-
Yoshida Takashi
Tsukuba Primte Center National Institute Of Infections Diseases
関連論文
- カニクイザルの網膜における黄斑および周辺網膜の比較プロテオミクス
- マウスノロウイルスS7株に対する特異抗体を検出するための間接ELISA法および間接蛍光抗体法
- Retroperitoneal Fibromatosis in a Cynomolgus Monkey (Macaca fascicularis)
- ストレプトゾトシン誘発糖尿病APAハムスターの大動脈における小胞体ストレス
- Astroglial responses against Aβ initially occur in cerebral primary cortical cultures : species differences between rat and cynomolgus monkey
- Immunohistochemical Analysis of Protein Gene Product 9.5, a Ubiquitin Carboxyl-terminal Hydrolase, during Placental and Embryonic Development in the Mouse
- Protective Effects of Probucol Treatment on Pancreatic β-cell Function of SZ-induced Diabetic APA Hamsters
- Characterization of the Testis in Congenitally Ubiquitin Carboxy-Terminal Hydrolase-1 (Uch-L1) Defective (gad) Mice
- Changes in mRNA Expression in Mouse Postnatal Cochlea by Differential Display Method
- The Effect of Probucol on Atherosclerosis in Streptozotocin-Induced Diabetic-Hyperlipidemic APA Hamsters in Different Stages of Atherosclerosis
- Histopathological Studies of Aortic Dissection in Streptozotocin-Induced Diabetic APA Hamsters
- Presenilin-2 in the cynomolgus monkey brain : investigation of age-related changes
- Comparative Study on Toxicokinetics of Bisphenol A in F344 Rats, Monkeys (Macaca fascicularis), and Chimpanzees (Pan troglodytes)
- Molecular Evolution Inferred from Immunological Cross-reactivity of Immunoglobulin G among Chiroptera and Closely Related Species
- Spontaneous T-cell-rich B-cell Lymphoma in a Cynomolgus Monkey (Macaca fascicularis)
- Squamous Cell Carinoma of the Oral Cavity in an Infant Cynomolgus Monkey
- Ratio of Leptin to Adiponectin as an Obesity Index of Cynomolgus Monkeys : Macaca Fascicularis
- Relationship between Body Weight and Hematological and Serum Biochemical Parameters in Female Cynomolgus Monkeys (Macaca fascicularis)
- Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys
- Comparison of the Effects of Two Fixatives for Immunolocalization of Testosterone in the Testes of the Cynomolgus Monkey, Mouse and Rat
- MEASUREMENTS OF TESTOSTERONE IN THE DIGESTIVE TRACT IN THE CYNOMOLGUS MONKEY
- Changes in Bone Mineral Density of Lumbar Vertebrae after Parturition in African Green Monkeys (Cercopithecus aethipos)
- The Region-Specific Functions of Two Ubiquitin C-Terminal Hydrolase Isozymes along the Epididymis
- No Regional Differences of Cytochrome P450 Expression in the Liver of Cynomolgus Monkeys (Macaca fascicularis)
- D-Galactosamine Induced Hepatocyte Apoptosis is Inhabited in vivo and in Cell Culture by a Calcium Calmodulin Antagonist, Chlorpromazine, and a Calcium Channel Blocker, Verapamil
- Renal Function Tests on Diabetes-Induced and Non-Induced APA Hamsters
- Analysis of cDNA Coding MHC Class II β Chain of The Chimpanzee (Pan troglodytes)
- Expression of Lipoprotein Receptors in the Aortic Walls of Diabetic APA hamsters
- Functional and Histochemical Analysis on Pancreatic lslets of APA Hamsters with SZ-Induced Hyperglycemia and Hyperlipidemia
- APA Hamster Model for Diabetic Atherosclerosis. 2. Analysis of Lipids and Lipoproteins
- Aortic Atheromatous Lesions Developed in APA Hamsters with Streptozotocin induced Diabetes: A New Animal Model for Diabetic Atherosclerosis. 1. Histopathological Studies
- Localization and Age-Related Changes in Cytochrome P450 Expression in APA Hamster Livers
- Histopathology of Natural Ebola Virus Subtype Reston Infection in Cynomolgus Macaques during the Philippine Outbreak in 1996
- Chronological and Spatial Analysis of the 1996 Ebola Reston Virus Outbreak in a Monkey Breeding Facility in the Philippines
- Differences between BALB/c and C57BL/6 Mice in Mouse Hepatitis Virus Replication in Primary Hepatocyte Culture
- Sendai Virus Vecto-mediated Gene Transfer of Glial Cell Line-Derived Nertotrophic Factor Prevents Delayed Neuronal Death after Transient Global Ischemia in Gerbils
- Acceptor Concentration Control of P-ZnSe Using Nitrogen and Helium Mixed Gas Plasma
- Planar-Doping of Molecular Beam Epitaxy Grown ZnSe with Plasma-Excited Nitrogen
- Nitrogen Doping of ZnSe and ZnCdSe with the Assistance of Thermal Energy and Photon Energy
- Synthesis and Release of Steroids in Intestines from Cynomolgus Monkeys(Macaca fascicularis)(Endocrinology)
- ENZYME ACTIVITIES RELATED TO TESTOSTERONE METABOLISM IN INTESTINAL TISSUES OF MALE CYNOMOLGUS MONKEYS
- Monitoring the Reproductive Status of Female Gorillas (Gorilla gorilla gorilla) by Measuring the Steroid Hormones in Fecal Samples
- ユビキチンのC末端加水分解酵素欠損は骨石灰化を減少させる(生理学)
- Safe And Efficient Collection of Cytokine-Mobilized Peripheral Blood Cells From Cynomolgus Monkeys (Macaca fascicularis) with Human Newborn-Equivalent Body Weights
- Changes in mRNA Expression in Mouse Postnatal Cochlea by Differential Display Method
- Cryopreservation of Brain Tissue for Primary Culture
- Effective Delivery of a Lipophilic 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) into Rat Lymphoid Tissues
- Development of an Immunofluorescence Method for the Detection of Antibodies to Ebola Virus Subtype Reston by the Use of Recombinant Nucleoprotein-Expressing HeLa Cells
- Opportunistic Pneumocystis carinii Infection in Red-Bellied Tamarins (Saguinus Iabiatus)
- Possible Role of Genetic Factor(s) on Age-related Increase of Peripheral CD4^+CD^+8 Double Positive T Cells in Cynomolgus Monkeys
- Peripheral blood extrathymic CD4^+CD8^+ T cells with high cytotoxic activity are from the same lineage as CD^+CD8^- T cells in cynomolgus monkeys
- Age-Related Changes in Major Lymphocyte Subsets in Cynomolgus Monkeys
- Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis
- Horizontal Transmission of Toxoplasma gondii in Squirrel Monkeys (Saimiri sciureus)
- Molecular Cloning of ELOVL4 Gene from Cynomolgus Monkey (Masasa fascicularis)
- Working Pressure Effects on Deposition of Large-Area Microcrystalline Silicon Films on Flexible Plastic Substrate at 130℃ : Semiconductors
- Excitation Frequency Effects on Large-Area Hydrogenated Amorphous Silicon Film Deposition Process Using Flexible Film Substrate : Semiconductors
- Familial early onset macular degeneration in cynomolgus monkeys (Macaca fascicularis)
- Osteolytic and osteosclerotic lesion in the femur associated with pustulosis palmaris plantaris
- Locking of the thumb in a patient with de Quervain's disease : a case report
- Tracing Metabolic Changes in Soybean Cotyledons during Germination by NMR(Biological Chemistry)
- Analysis of Physical States of Water in Soybean Seeds by NMR(Biological Chemistry)
- The Relationship between Imbibitional Damage and Initial Water Content of Soybeans(Biological Chemistry)
- Estimation of Biological Activities by NMR in Soybean Seeds during Maturation(Biological Chemistry)
- Non-destructive Analysis of the Oil Composition of Soybean Seeds by Natural Abundance Carbon-13 Nuclear Magnetic Resonance Spectroscopy(Food & Nutrition)
- カニクイザル(Macaca fascicularis)の大規模コロニーにおけるメスの繁殖特性
- Monitoring the Reproductive Status of Japanese Monkeys (Macaca fuscata) by Measurement of the Steroid Hormones in Fecal Samples
- A SIMPLE NON-INVASIVE METHOD TO MEASURE FECAL STEROID HORMONES FOR MONITORING THE REPRODUCTIVE STATUS OF FEMALE GREAT APES
- Senile Plaques in an Aged Western Lowland Gorilla
- Simple Method for Assaying Serum Oxytocin and Changes of Serum Oxytocin Level during Parturition in Cynomolgus Monkeys
- Possible Role of Peripheral CD14^ Monocytes in the Development of Collagen-Induced Arthritis in Cynomolgus Monkeys (Macaca fascicularis)
- A Relation between Lattice Parameters and Lattice Vibrations of Solid Solutions
- White matter activated glial cells produce BDNF in a stroke model of monkeys
- マウスノロウイルスS7株に対する特異抗体を検出するための間接ELISA法および間接蛍光抗体法
- Fertilization and preimplantation development of mouse oocytes after prolonged incubation with caffeine
- Pituitary Luteinizing Hormone Isohormones-Changes in Profiles during the Menstrual Cycle and Receptor Binding Activities in Cynomolgus Monkeys (Macaca fascicularis)
- Molecular Cloning and Expression Analysis of the Bat Toll-Like Receptor 3,7, and 9
- Molecular Cloning and Sequencing of the cDNAs Encoding the Bat Interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12p40, and Tumor Necrosis Factor-Alpha
- Direct Experimental Occlusion of the Distal Middle Cerebral Artery Induces High Reproducibility of Brain Ischemia in Mice