Synthesis and Release of Steroids in Intestines from Cynomolgus Monkeys(Macaca fascicularis)(Endocrinology)
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概要
- 論文の詳細を見る
To examine the synthesis and release of steroids in intestinal tissues from cynomolgus monkeys (Macaca fascicularis), we performed the following experiments: 1) incubated prepared intestinal tissues with [^3H]testosterone to study the conversion to other steroids; 2) used a radioimmunoassay to determine steroid levels in six segments of intestinal tissues and contents (duodenum, jejunum, ileum, cecum, colon, and rectum); 3) localized testosterone in the six intestinal segments by immunofluorescence histochemistry; and 4) determined steroid levels in feces from males and females of various ages by radioimmunoassay to examine a correlation between steroid levels and age or sex. In prepared intestinal tissues, testosterone was converted into androstenedione, 5α-dihydrotestosterone, and an unidentified substance; all of these steroids were detected in all segments of the intestinal tissues and contents by radioimmunoassay. Immunofluorescence showed that testosterone was located in all segments of intestinal epithelia. Androstenedione, testosterone, 5α-dihydrotestosterone, and the unidentified substance were also detected in feces, and their levels were not affected by the age or sex of the animal. The present findings in cynomolgus monkeys led us to conclude that 1) steroids were synthesized in the intestines; 2) intestinal steroids were released from the six intestinal tissues to the intestinal cavities and excreted outside the body with feces; and 3) intestinal steroids were released irrespective of age or sex of the animal. Intestinal steroids seem to be paracrine or exocrine agents and to have different characteristics from classical serum steroids.
- 社団法人日本動物学会の論文
- 2004-06-25
著者
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Machida Takeo
埼玉大学 理学部生体制御学科
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Machida Takeo
Department Of Regulation Biology Graduate School Of Fisheries Science And Engineering Saitama Univer
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Machida Takeo
Deparatment Of Regulation Biology Faculty Of Science Saitama University
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Machida Takeo
Graduate School Of Science And Engineering Saitama University
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YOSHIDA Takashi
Tsukuba Primte Center, National Institute of Infections Diseases
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CHEN Yang
Tsukuba Primate Center, National Institute of Infectious Diseases
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SANKAI Tadashi
Tsukuba Primate Center, National Institute of Infectious Diseases
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Chen Yang
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases:seiwa Pharmaceu
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Miyamoto Sachiko
Tsukuba Primate Center for Medical Science, National Institute of Infectious Diseases
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Miyamoto Sachiko
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases:graduate School
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Yoshida T
Nagoya Univ. Nagoya Jpn
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Yoshida T
Matsushita Electric Co. Tochigi Jpn
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Sankai T
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases
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Sankai T
Tsukuba Primate Research Center National Institute Of Biomedical Innovation
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Sankai Tadashi
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases
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Yoshida Takashi
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases
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Chen Y
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases:seiwa Pharmaceu
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Nakamura Shin'ichiro
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases:department Of V
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Machida T
Division Of Life Science Graduate School Of Science And Engineering Saitama University
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