Relationship between Body Weight and Hematological and Serum Biochemical Parameters in Female Cynomolgus Monkeys (Macaca fascicularis)
スポンサーリンク
概要
- 論文の詳細を見る
Obesity is a risk factor triggering a variety of metabolic diseases. Cynomolgus monkeys (Macaca fascicularis) exhibit spontaneous onset of obesity in adulthood, similar to such onset exhibited by humans. To clarify the characteristics accompanying obesity in female cynomolgus monkeys, we used simple and multiple regression analyses to determine the relationship between body weight and hematological and serum biochemical parameters as well as obesity-related hormones, namely, leptin and insulin. Simple regression analysis showed that body weight was significantly (P<0.05) correlated with leptin level, insulin level, hemoglobin concentration, hematocrit values, mean corpuscular volume, glucose concentration, and triglyceride concentration. In addition, a multiple regression model containing leptin level, insulin level, mean corpuscular volume, and red blood cell count explained 66.9% of the variance in body weight. Therefore, female cynomolgus monkeys show similar obesity characteristics to humans, i.e., obesity is associated with enhanced synthesis and excretion of leptin in adipocytes, high risk of diabetes mellitus, and high levels of hematocytes. Our results indicate that female cynomolgus monkeys are good models for studying obesity in humans.
- 社団法人 日本実験動物学会の論文
著者
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YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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Yoshikawa Y
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences Universtiy Of Tok
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YOSHIDA Takashi
Tsukuba Primte Center, National Institute of Infections Diseases
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CHEN Yang
Tsukuba Primate Center, National Institute of Infectious Diseases
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ONO Fumiko
Corporation for Production and Research of Laboratory Primates
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Chen Yang
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases:seiwa Pharmaceu
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Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Yoshida Takashi
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases
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Chen Y
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases:seiwa Pharmaceu
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Yoshida Takashi
Tsukuba Primte Center National Institute Of Infections Diseases
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