Differences between BALB/c and C57BL/6 Mice in Mouse Hepatitis Virus Replication in Primary Hepatocyte Culture
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概要
- 論文の詳細を見る
We previously showed that an intraperitoneal infection with mouse hepatitis virus (MHV) resulted in acute hepatic failure accompanying extremely elevated viral growth in the liver in interferon-γ-deficient BALB/c (BALB-GKO), but not C57BL/6 (B6-GKO) mice. To examine the basis of the strain difference against MHV infection in interferon-γ-deficient mice, viral replication in primary hepatocyte cultures from BALB/c and B6 mice with or without the IFN-γ gene was compared in vitro. The MHV replication in BALB/c hepatocytes with or without the IFN-γ gene was significantly higher than that in B6 hepatocytes with or without the IFN-γ gene, suggesting that there is a strain difference in MHV replication in hepatocytes. Since a significant difference in MHV replication in hepatocytes was not observed between wild type and IFN-γ-deficient mice of the same genetic background, the phenomenon is thought to be independent of IFN-γ. However, pretreatment of hepatocytes with recombinant mouse interferon-γ inhibited MHV replication in a dose-dependent fashion. The results are discussed with respect to the pathology of MHV infection in mice with or without the IFN-γ gene.
- 社団法人 日本実験動物学会の論文
- 2003-01-01
著者
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吉川 泰弘
東京大学 大学院農学生命科学研究科実験動物学教室
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YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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KAWAMURA Seiji
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, the University
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Yoshikawa Yasuhiro
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Kyuwa S
Univ. Tokyo Tokyo Jpn
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Kyuwa Shigeru
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Kyuwa Shigeru
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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URANO Toru
Division of Microbiology and Genetics
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Yoshikawa Y
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Yoshikawa Yasuhiro
Department Of Biomedical Science Graduate School Of Agricultural And Life Science University Of Toky
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Urano Toru
Division Of Microbiology And Genetics Center For Animal Resources And Development Kumamoto Universit
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Kawamura S
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Kawamura Seiji
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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KYUWA Shigeru
Center for Experimental Medicine, Institute of Medical Science, The University of Tokyo
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TAGAWA Yoh-ichi
Center for Experimental Medicine, Institute of Medical Science, The University of Tokyo
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IWAKURA Yoichirou
Center for Experimental Medicine, Institute of Medical Science, The University of Tokyo
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Tagawa Yoh-ichi
Center For Experimental Medicine Institute Of Medical Science The University Of Tokyo
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吉川 泰弘
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Kyuwa Shigeru
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences University Of Tok
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Kyuwa Shigeru
Department Of Reproductive And Developmental Biology Institute Of Medical Science The University Of
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Kyuwa Shigeru
Center For Experimental Medicine Institute Of Medical Science The University Of Tokyo
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Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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吉川 泰弘
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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吉川 泰弘
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Iwakura Yoichirou
Center For Experimental Medicine Institute Of Medical Science The University Of Tokyo
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Kawamura Seiji
Department Of Biomedical Science Faculty Of Agriculture And Life Sciences University Of Tokyo
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KAWAMURA Seiji
Department of Agriculture, The University of Tokyo
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