A Further Comparative Study on Early Histological Changes in Respiratory Tract of Brown Norway and Fischer 344 Rats after Short-Term Inhalation of Formaldehyde Aerosol
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概要
- 論文の詳細を見る
Early histological changes in the mucosa of the respiratory system were examined in Brown Norway (BN) and Fischer 344 (F344) rats exposed to aerosol inhalation of 1% formaldehyde (HCHO) solution of 3 or 5 days. Treatment-related clinical signs suggestive of respiratory disorders were more obviously observed in F344 rats than in BN rats. In F344 rats, mucosal changes were found in the nasal cavity and trachea. They were initiated by degeneration and/or desquamation of epithelial cells with inflammation and then followed by stratification or squamous metaplasia of epithelial cells. The incidence and extent of these lesions were increased with duration of exposure. On the other hand, similar but less severe changes were observed restricted to the nasal mucosa in BN rats. The degree of epithelial damage was consistent with that of mucosal inflammation, and squamous cell metaplasia occurred only in the portion where severe mucosal lesions preexisted. The present study confirms that BN rats are less sensitive to HCHO inhalation than F344 rats.
- 1998-12-01
著者
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Doi K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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土井 邦雄
Department of Radiology, The University of Chicago
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土井 邦雄
残留農薬研究所
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Harada Takanori
The Institute of Environmental Toxicology
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Harada Tomoko
協和醗酵工業
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Harada Tomoko
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Ohtsuka Ryoichi
The Institute Of Environmental Toxicology
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大塚 亮一
Institute Of Environmental Toxicology
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Ohtsuka Ryoichi
Department Of Biomedical Science The University Of Tokyo
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Doi Kunio
日本生物科学研究所
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Takeda Makio
The Institute of Environmental Toxicology
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Fujie Hideaki
The Institute of Environmental Toxicology
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原田 孝則
The Institute of Environmental Toxicology
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Yoshikawa Y
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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武田 真記夫
Institute Of Environmental Toxicology
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Takeda M
Kobe-university
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藤江 秀彰
The Institute Of Environmental Toxicology
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板垣 慎一
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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大塚 亮一
Department of Veterinary Pathology, The University of Tokyo
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首藤 康文
The Institute of Environmental Toxicology
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武田 真記夫
The Institute of Environmental Toxicology
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吉川 泰弘
Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo
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Takeda Makio
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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首藤 康文
岩手大学農学部家畜解剖学教室
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吉川 泰弘
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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土井 邦雄
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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板垣 慎一
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Itagaki Shin-ichi
Department Of Biomedical Science The University Of Tokyo
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吉川 泰弘
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Fujie Hideaki
Toxicology Division The Institute Of Environmental Toxicology
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Itagaki Shin-ichi
Department Of Biomedical Science Faculty Of Agriculyure The University Of Tokyo
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