Comparative Study on Picryl Chloride (PCL)-Induced Contact Dermatitis in Female IQI/Jic and BALB/c Mice
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概要
- 論文の詳細を見る
Ear skin responses to picryl chloride (PCL)-induced contact dermatitis were compared in detail between IQI/Jic mice developed in Japan and BALB/c mice often used for the investigation of contact dermatitis. PCL was applied to the left ear of each mouse 4 (1st), 11 (2nd), 18 (3rd) and 25 days (4th) after sensitization of the abdominal skin with PCL. Time course examinations were carried out on the ear swelling responses, total IgE levels, skin histology and immunohistochemistry for infiltrated cells after the 1st and 4th application. In IQI mice, the peak time of the ear swelling responses tended to shift from 24 h to 9 h with marked elevation of total IgE levels and marked increase of mast cells showing degranulation after the 4th application when CD8+ cells as well as CD4+ cells also prominently increased. In BALB/c mice, except for the total IgE levels and the number of mast cells, the degrees of ear swelling responses, histological changes and increase of CD4+ and CD8+ cells were much less severe. Female IQI mice are considered to be a useful mouse strain for further investigations on the role of CD4+ and CD8+ T cells in the pathogenesis of contact dermatitis.
- 社団法人 日本実験動物学会の論文
著者
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土井 邦雄
残留農薬研究所
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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Doi K
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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NAKAYAMA Hiroyuki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Shinozuka Junko
田辺三菱製薬
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Doi Kunio
日本生物科学研究所
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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JUNG Ji-Youn
Department of Companion and Laboratory Animal Science, Kongju National University
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Jung Ji-youn
Department Of Companion And Laboratory Animal Science Kongju National University
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Jung Ji-youn
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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SAEGUSA Junzo
Department of Human Engineering, National Institute of Industrial Health
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Saegusa J
National Inst. Industrial Health Kawasaki Jpn
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Saegusa Junzo
National Institute Of Occupational Safety And Health
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Saegusa Junzo
Department Of Experimental Toxicology National Institute Of Industrial Health
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Saegusa Junzo
Department Of Human Engineering National Institute Of Industrial Health
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Doi K
Nippon Inst. For Biological Sci.
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Nakayama Hiroyuki
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Nakayama Hiroyuki
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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