Liver Responses to Repeated Doses of Carbon Tetrachloride in Mini and Wistar Rats
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概要
- 論文の詳細を見る
The liver responses to repeated doses of CCl4 (0.5 mg/kg b.w., twice weekly) were compared between Wistar and Mini rats, in which the expression of growth hormone (GH) gene is suppressed by the presence of an antisense gene, at 2, 4, and 6 weeks after treatment (WAT). Fibrosis started earlier and its degree was severer in Mini rats than in Wistar rats, and hepatocyte damage was also severer in Mini rats than in Wistar rats. This corresponded well with the changes in serum AST and ALP levels. Oval cell proliferation in the fibrous septa of the liver of CCl4-treated Mini rats may also have some relations to such increase in ALP activity and fibrogenesis in Mini rats. The increase in the level of TGF-β1 mRNA was more prominent in Mini rats than in Wistar rats at 4 and 6 WAT, and this corresponded to the strain difference in the degree of liver fibrosis. The present results indicate that the responsibility of the liver to repeated doses of CCl4 was different between Mini rats and Wistar rats. Mini rats seem to be useful as a new tool in the investigation of regulatory mechanisms of GH on liver injury and regeneration.
- 日本毒性病理学会の論文
- 2002-06-30
著者
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Doi K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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土井 邦雄
産業医総研
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土井 邦雄
残留農薬研究所
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Nakayama H
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences University Of T
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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NAKAYAMA Hiroyuki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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UETSUKA Koji
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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UETSUKA Koji
Dept. VetPathol., Univ. Tokyo
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OKADA Taro
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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SHIMIZU Hiroko
Department of Veterinary Pathology, Graduate School of Agricultural anf Life Sciences, The Universit
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Okada Taro
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Okada Taro
Department Of Marine Biotechnology Faculty Of Engineering Fukuyama University
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Nakayama Hiroyuki
東京大学 農学生命科学研究科獣医病理学
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Nakayama H
Dep. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Doi Kunio
日本生物科学研究所
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土井 邦雄
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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Uetsuka K
Univ. Tokyo Tokyo
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Uetsuka Koji
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Uetsuka K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Doi K
Nippon Inst. For Biological Sci.
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Shimizu Hiroko
Department Of Veterinary Pathology Graduate School Of Agricultural Anf Life Sciences The University
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Nakayama Hiroyuki
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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SHIMIZU Hiroko
Department of Chemistry, University of Hawaii at Manoa
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