1-β-D-Arabinofuranosylcytosine (Ara-C)-induced Apoptosis in the Rat Fetal Tissues and Placenta
スポンサーリンク
概要
- 論文の詳細を見る
1-β-D-Arabinofuranosylcytosine (Ara-C), a cytidine analogue, inhibits DNA synthesis and is used for the treatment of myelogenous leukemia. On the other hand, it is also known that Ara-C has a teratogenic effect. In the present study, pregnant rats were treated with 250 mg/kg of Ara-C on day 13 of gestation, and fetal tissues and placentae were collected from 3 to 48 hours after treatment to examine the sequential histopathological changes induced by prenatal Ara-C treatment. The weights of fetuses and placentae and the thickness of the placental labyrinth zone were significantly reduced at 48 hours after treatment. In the fetal tissues such as central nervous system and mesenchymes and in the placental labyrinth zone, the number of pyknotic cells stained positively by the TUNEL method increased markedly after treatment with Ara-C. In most fetal tissues, the number began to increase from 3 to 6 hours and peaked at 9 to 12 hours after treatment. In the placental labyrinth zone, the number peaked at 6 hours after treatment. Electron microscopical features of the pyknotic cells consisted with the ultrastructural characteristics of apoptotic cells. In various fetal organs and placentae, abnormal induction of apoptosis is suggested to induce growth inhibition and have a certain relation to the malformations. Moreover, abnormal induction of apoptosis would have a deep connection with the cytotoxic effect of Ara-C which may affect proliferative cells in fetuses and placentae developing rapidly.
- 日本毒性病理学会の論文
- 2003-12-30
著者
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Doi K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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土井 邦雄
産業医総研
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土井 邦雄
残留農薬研究所
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Nakayama H
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences University Of T
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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YASOSHIMA Akira
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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NAKAYAMA Hiroyuki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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UETSUKA Koji
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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UETSUKA Koji
Dept. VetPathol., Univ. Tokyo
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KATAYAMA Kei-ichi
Dep. of Vet. Pathol., Grad. Sch. Agr. Life Sci., Univ. Tokyo
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KATAYAMA Kei-ichi
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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YAMAUCHI Hirofumi
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Nakayama Hiroyuki
東京大学 農学生命科学研究科獣医病理学
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Nakayama H
Dep. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Yasoshima A
Pharmaceutical Development Research Laboratory Tanabe Seiyaku Co. Ltd.
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Yasoshima Akira
Dep. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Yasoshima Akira
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Yasoshima Akira
田辺製薬
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Doi Kunio
日本生物科学研究所
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土井 邦雄
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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Uetsuka K
Univ. Tokyo Tokyo
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Uetsuka Koji
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Doi Kunio
Faculty Of Agriculture The University Of Tokyo
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Yamauchi Hirofumi
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Katayama Kei-ichi
Dpt. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University Of Tok
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Katayama Kei-ichi
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Doi K
Univ. Tokyo Tokyo Jpn
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Uetsuka K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Nakayama Hiroyuki
Laboratory Of Veterinary Pathology Graduate School Of Agriculture And Life Science The University Of
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Nakayama Hiroyuki
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Science The University O
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Doi K
Nippon Inst. For Biological Sci.
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Nkayama Hiroyuki
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Science The University O
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Nakayama Hiroyuki
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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