Rapid Induction of Liver Cirrhosis in Mini Rats by Thioacetamide
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概要
- 論文の詳細を見る
A histopathological study was carried out on the liver of thioacetamide (TAA)-treated rats of Jcl: Wistar-TgN(ARGHGEN)1Nts strain (Mini rats), in which the expression of growth hormone (GH) gene is suppressed by the presence of antisense transgene, resulting in the reduction of plasma GH levels. Male Wistar (the parental strain of Mini rats) and Mini rats of 4-6 weeks of age were treated with 0.03% TAA in drinking water for up to 8 weeks. The survival rates of Wistar and Mini rats were 91% and 89%, respectively. Plasma alkaline phosphatase activity and total bilirubin concentration in TAA-treated Mini rats increased to a greater extent than those in TAA-treated Wistar rats. Histopathologically, the liver of TAA-treated Mini rats revealed proliferation of ‘atypical’ hepatocytes throughout the course of the experiment. In addition, fibrosis from the periportal area to the centrilobular region associated with oval cell proliferation was observed at 2 weeks. At 8 weeks, cirrhosis accompanied with proliferation of bile duct epithelial cell-like cells was evident. In the liver of Wistar rats, There were only atypical hepatocytes and slight fibrosis without cirrhotic features even at 8 weeks. These results demonstrate a great advantage in the use of Mini rats to produce liver cirrhosis within a short term and suggest some possible relationships between GH deficiency and experimental cirrhogenesis.
- 日本毒性病理学会の論文
- 1998-06-01
著者
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Doi K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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土井 邦雄
Department of Radiology, The University of Chicago
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土井 邦雄
残留農薬研究所
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Nakayama H
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences University Of T
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中山 裕之
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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Tani Yoshiro
東京大学 農学生命科研究科
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谷 吉朗
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Tani Yoshiro
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
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Tani Yoshiro
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Nakayama H
Dep. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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上塚 浩司
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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谷 吉朗
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
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Doi Kunio
日本生物科学研究所
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Uetsuka K
Univ. Tokyo Tokyo
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MIZUNO Hatsue
Medicinal Safety Research Laboratories
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FUKUSHIGE Junichiro
Lab. Anim. Sci. Toxicol. Labs., Sankyo Co., Ltd.
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福重 潤一郎
Lab. Anim. Sci. Toxicol. Labs. Sankyo Co. Ltd.
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村田 信次
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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梶原 幸子
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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水野 初枝
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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福重 潤一郎
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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細川 常通
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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土井 邦雄
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Uetsuka K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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水野 初枝
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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中山 裕之
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Science The University O
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細川 常通
Medicinal Safety Research Laboratories
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村田 信次
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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谷 吉朗
三共
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梶原 幸子
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Nakayama Hiroyuki
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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