5-Azacytidine-induced Apoptosis in the Central Nervous System of Developing Rat Fetuses
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概要
- 論文の詳細を見る
Pregnant Wistar rats were injected i.p. with 5-azacytidine (5AzC) at 11 day of gestation. Brain cell apoptosis determined morphologically or by TUNEL method was observed in the fetuses 3 hrs after injection. Eight to 100% of the fetuses were dead at 1 to7 day after injection. Injection with doses less than 5 mg/kg of 5AzC killed only a few fetuses, though neuronal apoptosis was detected in most of living fetuses. All fetuses were dead when their dams were injected with 5AzC at 9 or 10 day of gestation, whereas most of the fetuses were alive when injected after day 12. The present study revealed that 5AzC specifically induce neuronal apoptosis in rat fetuses at the stage of logarithmic growth.
- 日本毒性病理学会の論文
- 1998-06-01
著者
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Doi K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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土井 邦雄
Department of Radiology, The University of Chicago
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土井 邦雄
残留農薬研究所
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Nakayama H
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences University Of T
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中山 裕之
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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UETSUKA Koji
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Nakayama H
Dep. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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SHINOZUKA Junko
Depart.Vet.Pathol., Fac.Agriculture, Univ.Tokyo
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Shinozuka Junko
田辺三菱製薬
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Doi Kunio
日本生物科学研究所
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呂 東平
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Uetsuka K
Univ. Tokyo Tokyo
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Uetsuka Koji
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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TAKI Ryuichi
Mitsubishi Kagaku Bio-Clinical Laboratories, Inc.
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土井 邦雄
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Taki Ryuichi
Mitsubishi Kagaku Bio-clinical Laboratories Inc.
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Uetsuka K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Saegusa J
National Inst. Industrial Health Kawasaki Jpn
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Saegusa Junzo
National Institute Of Occupational Safety And Health
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Saegusa Junzo
Department Of Human Engineering National Institute Of Industrial Health
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中山 裕之
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Science The University O
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Nakayama Hiroyuki
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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