Hepatitogenicity of Three Plaque Purified Variants of Hepatotropic Mouse Hepatitis Virus, MHV-2 in Athymic Nude Mice
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概要
- 論文の詳細を見る
Hepatitogenicity of 3 plaque purified variants of hepatotropic mouse hepatitis virus, MHV-2 were examined in athymic BALB/c-nu/nu mice up to 9 weeks post infection (9WPI). All of the MHV-2S- and MHV-2M-infected mice died with severe acute hepatitis in 3WPI. On the other hand, MHV-2L-infected mice did not die until 9WPI and showed signs of slow-developing chronic hepatitis with persistent infection under low serum virus neutralizing antibody titers. This suggests that MHV-2L-infected athymic nude mice may be useful as a new model of chronic viral hepatitis.
- 社団法人 日本実験動物学会の論文
著者
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NAKAYAMA Hiroyuki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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UETSUKA Koji
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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UETSUKA Koji
Dept. VetPathol., Univ. Tokyo
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Uetsuka Koji
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Uetsuka K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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GOTO Naoaki
Shin Nippon Biomedical Laboratories, Ltd., Tokyo Byouri Center
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Nakayama Hiroyuki
Laboratory Of Veterinary Pathology Graduate School Of Agriculture And Life Science The University Of
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Goto N
Shin-nihon Kagaku Tokyo Pathology Center
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