HEPATIC AND INTESTINAL CHANGES IN RATS TREATED WITH T-0126, A MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) INHIBITOR
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概要
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In the present study, we investigated the potential toxic effects of 2-week oral treatment with T-0126, a novel microsomal triglyceride transfer protein (MTP) inhibitor, on the liver and intestine in male and female rats. Administration of T-0126 decreased serum lipids and resulted in fat accumulation in the liver and the small intestine. In addition, slight changes in the liver, including an increase in serum aminotransferase (AST and ALT) activity, presence of focal inflammatory lesions, and prolongation of PT and APTT were observed after treatment with T-0126. These changes may be related to a mechanism based on malabsorption of fat, fat-soluble antioxidants, and vitamin K, although we cannot exclude other potential mechanisms such as direct cytotoxicity of T-0126.
- 日本トキシコロジー学会の論文
- 2007-05-16
著者
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NAKAYAMA Hiroyuki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Toriumi Wataru
Exploratory Toxicology & Dmpk Research Laboratories Tanabe Seiyaku Co. Ltd.
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KITAMURA Kazuyuki
Drug Safety Research Laboratories, Tanabe Seiyaku Co., Ltd.
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Kitamura Kazuyuki
Safety Res. Lab. Mitsubishi Tanabe Pharma Corp.
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Miwa Satoko
Exploratory Toxicology & Dmpk Research Laboratories Tanabe Seiyaku Co. Ltd.
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Miwa Satoko
Tanabe Seiyaku Co. Ltd
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MIYAGISHIMA Toshikazu
Toxicogenomics Project, National Institute of Biomedical Innovation
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Kume Eisuke
Strategic Research Planning & Management Div. Research Headquarters Tanabe Seiyaku Co. Ltd.
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Nagata Koichi
Strategic Research Planning & Management Div. Research Headquarters Tanabe Seiyaku Co. Ltd.
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Yamada Harutami
Intellectual Property Div. Research Headquarters Tanabe Seiyaku Co. Ltd.
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MIYAZAKI Tohiko
Exploratory Toxicology & DMPK Research Laboratories, Tanabe Seiyaku Co., Ltd.
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KODAMA Hirohiko
Exploratory Toxicology & DMPK Research Laboratories, Tanabe Seiyaku Co., Ltd.
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Torium Wataru
Tanabe Seiyaku Co. Ltd
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Kitamura Kazuyuki
Drug Safety Research Laboratories Tanabe Seiyaku Co. Ltd.
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Kodama Hirohiko
Exploratory Toxicology & Dmpk Research Laboratories Tanabe Seiyaku Co. Ltd.
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Nakayama Hiroyuki
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Miyazaki Toshiko
Exploratory Toxicology & DMPK Research Laboratories, Tanabe Seiyaku Co., Ltd.
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