A comparative pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs
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概要
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Histiocytic proliferative disorders in canine central nervous system (CNS) including granulomatous meningoencephalomyelitis (GME) and malignant histiocytosis were compared pathologically. Lesions of GME mainly existed in the white matter of the cerebrum, brainstem and cerebellum and consisted of characteristic perivascular cuffing, parenchymal granuloma and leptomeningeal infiltrates of mononuclear cells. In malignant histiocytosis, there were two histological patterns, diffuse proliferation of neoplastic histiocytes through the leptomeninges and neoplastic nodule formation in the parenchyma. Neoplastic; histiocytes exhibited mild to severe cellular atypia and high ability of invasion into the brain parenchyma. Mitotic and phagocytic figures were also observed. Several histiocytic markers, including lysozyme, al-antitrypsin and lectin RCA-1, revealed histiocytic origin of both inflammatory and neoplastic cells, however, those were not determinative for the discrimination between GME and malignant histiocytosis. CD3- and PCNA-positive cells existed in the lesions of both diseases. The number of CD3-positive cells in GME tended to be greater than in malignant histiocytosis, while the difference was not statistically significant.肉芽腫性髄膜脳脊髄炎(GME)と悪性組織球症を含む大の中枢神経系(CNS)における組織球増殖疾患を病理学的に比較した.GMEの病変は主として大脳白質,脳幹,小脳に存在し,脳実質における囲管性細胞浸潤と肉芽腫形成,髄膜への単核球浸潤により構成されていた.悪性組織球症は,髄膜への滞漫性播種と腫癌形成の2種の組織型を示した.腫癌性組織球は中等度～高度の細胞異型を呈し,脳実質への浸潤性が高度で,核分裂像や会食像も観察された.リゾチーム,α1-アンチトリプシン,レクチンRCA-1等の組織球マーカーにより炎症性あるいは腫癌性細胞が組織球由来であることが示されたが,GMEと組織球症の鑑別上,有効性は認められなかった.cDS及びPCNA陽性細胞が両疾患の病変中に見出され,GMEにおけるCD3陽性細胞数が悪性組織球症よりも多い傾向にあったが,その差は統計学的に有意ではなかった.
著者
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Morozumi Motoji
Togasaki Animal Hospital
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Uchida Kazuyuki
Department Of Veterinary Pathology Graduated School Of Agricultural And Life Sciences The University
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Suzuki Mari
Department Of Dermatology Nissan Tamagawa Hospital
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YANAI Tokuma
Department of Pathogenetic Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
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Nakayama Hiroyuki
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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内田 和幸
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
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鈴木 麻理
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
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SUZUKI Mari
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
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