Histopathological Characteristics of Ito Cells and Kupffer Cells in the Feline Liver
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概要
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The histopathological characteristics of Ito cells and Kupffer cells were investigated in the liver of 21 cats (age range: 6 months -18 years) autopsied in our laboratory during 2003. Immunohistochemical examinations were performed using antibodies against lysozyme, desmin and α-smooth muscle actin. No Kupffer cells reacted with the antibody against lysozyme. However, macrophages in the lung and spleen showed a positive reaction with the antibody. This finding suggests a possibility that the amount of lysozyme in the Kupffer cells of feline liver is comparatively small. On the other hand, large vacuole-laden cells were observed in the hepatic perisinusoid of some feline cases, and these cells showed a positive reaction with antibodies against desmin and α-smooth muscle actin. These cells could be Ito cells with large lipid vacuoles. This conclusion was supported by electron microscopic observation and oil red O staining. However, no such large vacuole-laden perisinusoidal cells were detected in the liver of young cats less than 2 years old. The present study revealed the histopathological features of Kupffer cells and Ito cells in the feline liver.
- 公益社団法人 日本獣医学会の論文
著者
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Yasoshima Akira
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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Uetsuka Koji
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Nishikawa Satomi
Department Of Molecular Genetics Faculty Of Medicine And Graduate School Of Medicine
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Yasoshima Akira
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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NISHIKAWA Satomi
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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