Age-Related Changes in Susceptibility of Mice to Low-Virulent Mouse Hepatitis Virus (MHV-2-CC) Infection

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概要

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• This study was performed to examine mouse age-dependent changes in susceptibility to MHV-2-CC-infection and participation of macrophages in such changes in BALB/c mice. One-week-old mice were fully susceptible (mortality, 100%), 2-week-old semi-susceptible (36%), and 3- and 4-week-old fully resistant (0%) to MHV-2-CC, respectively. Such age-dependent differences corresponded well with the differences in the virus titers in the liver, spleen and blood and in the severity of liver lesions. In 1-week-old mice with peritoneal exudate cells (PEC) transferred from 4-week-old mice and infected with MHV-2-CC, a slight prolongation of survival time was recorded, although there was no difference in mortality. In 3-week-old mice infected with MHV-2-CC after silica-treatment to suppress macrophages, there was no significant change in susceptibility. In macrophages infected with MHV-2-CC in vitro, the virus replicated better in macrophages obtained from younger mice. These results suggest that macrophages may play a small role in the age-related development of resistance to MHV-2-CC infection in BALB/c mice.

• 社団法人　日本実験動物学会の論文

著者

• 土井 邦雄

  残留農薬研究所

• Nakayama H

  Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences University Of T

• Doi Kunio

  Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo

• NAKAYAMA Hiroyuki

  Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit

• Kiatipattanasakul W

  Univ. Tokyo Tokyo Jpn

• Kiatipattanasakul Wijit

  Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo

• Nakayama Hiroyuki

  Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine

• 鈴木 浩悦

  日本獣医生命科学大学獣医学部

• Doi Kunio

  日本生物科学研究所

• TSUTSUI Shigeki

  Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University

• Doi Kunio

  Department Of Applied Chemistry Nagoya Institute Of Technology

• KAJIKAWA Satoru

  Drug Safety Research Laboratories, Astellas Pharma Inc.

• Suzuki Hodaka

  Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit

• KIATIPATTANSAKUL Wijit

  Department of Veterinary Pathology, The University of Tokyo

• KAJIKAWA Satoru

  Department of Veterinary Pathology, The University of Tokyo

• GOTO Naoki

  Shin Nippon Biomedical Laboratories, Ltd.

• 土井 邦雄

  Department Of Veterinary Pathology Graduate School Of Agricultural And Life Science The University O

• Kajikawa Satoru

  Drug Safety Research Laboratories Astellas Pharma Inc.

• Kajikawa Satoru

  アステラス製薬

• Suzuki Hiroetsu

  Department Of Veterinary Physiology Nippon Veterinary And Animal Science University

• Suzuki Hodaka

  Department Of Internal Medicine Iii Fukushima Medical University School Of Medicine

• Suzuki Hodaka

  Department Of Veterinary Pathology The University Of Tokyo

• Tsutsui Shigeki

  東京大学 農生命科研究

• Tsutsui Shigeki

  Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of

• Kajikawa Satoru

  Drug Safety Research Laboratories Astellas Pharma Inc. Itabashi

• Doi K

  Nippon Inst. For Biological Sci.

• Goto Naoki

  Shin Nippon Biomedical Laboratories Ltd.

• Kiatipattansakul Wijit

  Department Of Veterinary Pathology The University Of Tokyo

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