Fibrinoid Leukodystrophy (Alexanders Disease-Like Disorder) in a Young Adult French Bulldog
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概要
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The paper describes clinical and pathological features of Alexanders disease (AD)-like disorder in a 1 year and 8 months old French bulldog. Clinically, the dog exhibited megaesophagus, general emaciation and weakness without any specific neurological symptoms. The dog died due to aspiration pneumonia. By gross observation of formalin-fixed brain, discolored foci were observed in the white matter of the cerebellum and brain stem. Histologically, numerous Rothenthal fibers and hypertrophic astrocytes were distributed especially in the perivascular, subependymal and subpial area of both the cerebrum and cerebellum. The Rosenthal fibers were intensely immunopositive for GFAP and ubiquitin. The white matter demyelination was occasionally found in the brain stem. The present case is likely to be categorized in the adult form of AD, though previous AD-like cases in dogs were in the juvenile form.
著者
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NAKAYAMA Hiroyuki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Uchida Kazuyuki
Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
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ITO TSUYOSHI
Department of Agricultural Chemistry, Faculty of Agriculture, Okayama University
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NAKASHIMA Ko
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Suzuki Kazuhiko
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Nakamura Masatoshi
Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical
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Ito Tsuyoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Okayama University
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Uchida Kazuyuki
Department Of Veterinary Pathology Graduated School Of Agricultural And Life Sciences The University
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Suzuki Kazuhiko
Department Of Electrical Engineering Hokkaido Institute Of Technology
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Nakamura Masatoshi
Department Of Advanced Systems Control Engineering Saga University
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