Endothelial Hypertrophy in Acute Phase of Arteritis Induced by Fenoldopam, a Vasodilator, in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Fenoldopam, a dopaminergic (DA1) agonist, has been known to induce arteritis in the splanchnic arteries in rats by intravenous infusion. The arteritis was characterized by medial necrosis, hemorrhage, and endothelial hyperplasia in the acute phase and subsequent inflammatory responses in the adventitia. In the present study, the hypertrophic endothelial cells were examined immunohistochemically and electronmicroscopically. Immunohistochemical examination revealed marked positive reactions of von Wilbrand factor (vWF) and factor VIII in the endothelial cells. Electronmicroscopically, the number of rough endoplasmic reticulum (rER) and the size of the nucleolus were increased. These results suggest that endothelial hypertrophy in the acute phase of fenoldopam-induced arteritis is associated with increased protein synthesis of vWF and factor VIII in response to medial necrosis and hemorrhage.
- 日本毒性病理学会の論文
- 2002-06-30
著者
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Doi K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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土井 邦雄
産業医総研
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土井 邦雄
残留農薬研究所
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Nakayama H
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences University Of T
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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NAKAYAMA Hiroyuki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Nakayama Hiroyuki
東京大学 農学生命科学研究科獣医病理学
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Nakayama H
Dep. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Doi Kunio
日本生物科学研究所
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Ito K
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Ito Kohzo
Graduate School Of Frontier Sciences University Of Tokyo
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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KAJIKAWA Satoru
Drug Safety Research Laboratories, Astellas Pharma Inc.
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KAJIKAWA Satoru
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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IKEGAMI Hisashi
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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MIURA Hisaki
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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ITO Kyoko
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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OKAMIYA Hideaki
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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伊藤 今日子
Medicinal Safety Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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土井 邦雄
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Science The University O
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Ito K
Drug Safety Research Laboratories Astellas Pharma Inc.
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Miura Hisaki
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Nakayama Hiroyuki
Laboratory Of Veterinary Pathology Graduate School Of Agriculture And Life Science The University Of
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Ikegami Hisashi
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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池上 仁
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Kajikawa Satoru
Drug Safety Research Laboratories Astellas Pharma Inc.
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Kajikawa Satoru
アステラス製薬
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Kajikawa Satoru
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Okamiya Hideaki
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Okamiya Hideaki
Safety Research Laboratories Product Development Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Nakayama Hiroyuki
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Science The University O
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Kajikawa Satoru
Drug Safety Research Laboratories Astellas Pharma Inc. Itabashi
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Doi K
Nippon Inst. For Biological Sci.
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Nkayama Hiroyuki
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Science The University O
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Nakayama Hiroyuki
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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伊藤 今日子
Safety Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Ito Kyoko
Safety Research Laboratories, Yamanouchi Pharmaceutical Co Ltd.
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ITO Kyoko
Safety Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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