Ultrastructure of the Dorsal Skins of Hairless Descendants Derived from Mexican Hairless Dogs

概要

論文の詳細を見る
Ultrastructural characteristics of the dorsal skin of hairless descendants derived from Mexican hairless dogs (3-month-, 1-year-and 5-year-old) were investigated and compared with those of age-matched beagles. Except that beagles had no melanocytes in epidermis, there was no essential difference in ultrastructural characteristics of epidermis between hairless dogs and beagles. In the Stratum basale of epidermis of hairless dogs, a small number of melanocytes and a few Langerhans cell (LC)-like cells were observed among keratinocytes. Melanocytes contained many melanosomes and a few premelanosomes. LC-like cells were characterized by electron-lucent cytoplasm and lobulated nucleus and lacked melanin granules, tonofilaments and desmosomal attachments. Unlike LC in humans and rodents, these LC-like cells did not contain Birbeck granules. Although age-related ultrastructural changes of dorsal skin were generally not clear both in hairless dogs and in beagles, cells containing melanin granules were not infrequently observed among dermal collagen bundles in 5-year-old hairless dogs.
社団法人　日本実験動物学会の論文
1995-10-01