Involvement of Macrophages in the Development of Encephalomyocarditis (EMC) Virus-Induced Diabetes in Mice
スポンサーリンク
概要
- 論文の詳細を見る
The role of macrophages in the development of diabetes following infection with encephalomyocarditis (EMC) virus was examined in 3 strains of mice (DBA/2 and BALB/c: susceptible, C57BL/6: resistant). After infection with 100 plaque forming units (PFU) / head of EMC-D (highly diabetogenic variant), the incidence of diabetes at 3 days post infection (DPI) (DBA/2: 7/8, BALB/c: 3/8, C57BL/6: 0/8) was well correlated with the severity of macrophage infiltration with β cell damage in the pancreatic islets (DBA/2: sever, BALB/c: moderate, C57BL/6: slight). Silica-pretreatment depleted macrophage infiltration in the pancreatic islets and decreased the incidence of diabetes at 7 DPI from 100% to 40% in DBA/2 and from 80% to 0% in BALB/c mice, respectively. These results suggest that macrophages play a critical role in the process of pancreatic β cell damage in EMC virus infection in mice.
- 社団法人 日本実験動物学会の論文
著者
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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ITAGAKI Shin-ichi
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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HIRASAWA Kensuke
Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo
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土井 邦雄
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Takeda Makio
The Institute of Environmental Toxicology
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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武田 真記夫
Institute Of Environmental Toxicology
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Takeda M
Kobe-university
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Hirasawa Kazuo
Ina Research Laboratory Kitayama Labes Co. Ltd.
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Doi Kunio
Faculty Of Agriculture The University Of Tokyo
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武田 真記夫
The Institute of Environmental Toxicology
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Takeda Makio
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Hirosawa Kensuke
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Hirasawa Kensuke
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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板垣 慎一
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Itagaki Shin-ichi
Department Of Biomedical Science The University Of Tokyo
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Doi K
Faculty Of Agriculture The University Of Tokyo
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Itagaki Shin-ichi
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Itagaki Shin-ichi
Department Of Biomedical Science Faculty Of Agriculyure The University Of Tokyo
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Takeda Makio
Department of Biological and Environmental Sciences, Graduate School of Agricultural Science, Kobe University
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