The Influence of Pre- and Post-natal Exposure to Methoxychlor on the Immune System and Renal Function of Sprague-Dawley Rats
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概要
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We previously demonstrated that rat offspring exposed perinatally to methoxychlor (MXC) still exhibited immunotoxic changes in young adulthood at 10 weeks of age. That result led us to further investigate whether the influence of perinatal exposure to MXC on the rat immune system persistently remains in adult life. Sprague-Dawley rat offspring of both sexes from dams receiving MXC at dietary dose levels of 0, 30, 100, 300, and 1000 ppm were used for the present study. The pups exposed to MXC through the placenta, milk, and/or direct intake during the gestation and lactation periods were maintained on a normal diet from weaning up to 52 weeks of age. At the termination, a significant increase in plasma chloride was noted in both sexes at 300 and 1000 ppm MXC exposure. Females at 1000 ppm MXC exposure showed increases in serum IgM and urinary protein and had significantly increased relative weights (ratio to body weight) of the spleen and kidneys. An increased relative kidney weight was also noted in females at 300 ppm MXC exposure. Histopathologically, the incidence and severity of chronic nephropathy tended to be higher in females at 1000 ppm MXC exposure, and their kidneys had enlarged glomeruli with increased IgG and IgM deposits. In the immune system, however, there were neither notable histological changes nor significant alterations in the splenic lymphocyte subsets for any dose group of either sex. These results indicate that the immunotoxic damage caused by pre- and post-natal MXC exposure appears to be repaired during the process of growth, although the effect seems to remain in females even at 52 weeks after birth and consequently may accelerate the progression of chronic nephropathy.
- 日本毒性病理学会の論文
- 2005-06-30
著者
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
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Kojima Sayuri
The Institute of Environmental Toxicology
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Sasaki Junya
The Institute of Environmental Toxicology
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Yoshida Toshinori
The Institute of Environmental Toxicology
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Kosaka Tadashi
The Institute of Environmental Toxicology
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Harada Takanori
The Institute of Environmental Toxicology
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Mitsumori Kunitoshi
杏林製薬研究センター
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Maita Keizo
The Institute of Environmental Toxicology
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Kuwahara Maki
The Institute of Environmental Toxicology
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Takeuchi Yukiko
The Institute of Environmental Toxicology
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Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
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Sasaki Jyunya
The Institute Of Environmental Toxicology
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Kuwahara M
Inst. Environmental Toxicology Ibaraki Jpn
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Kuwahara Maki
Laboratory Of Pathology Toxicology Division Chemistry Division Institute Of Environmental Toxicology
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Harada Tomoko
協和醗酵工業
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Harada Tomoko
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Ohtsuka Ryoichi
The Institute Of Environmental Toxicology
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大塚 亮一
Institute Of Environmental Toxicology
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Ohtsuka Ryoichi
Department Of Biomedical Science The University Of Tokyo
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Takeda Makio
The Institute of Environmental Toxicology
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MITSUMORI Kunitoshi
Institute of Environmental Toxicology
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TAKAHASHI Kazuaki
Institute of Environmental Toxicology
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原田 孝則
The Institute of Environmental Toxicology
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武田 真記夫
Institute Of Environmental Toxicology
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Takeda M
Kobe-university
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Kosaka T
Toxicology Division Institute Of Environmental Toxicology
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Chiba Yuko
The Institute Of Environmental Toxicology
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TAKAHASHI Naofumi
The Institute of Environmental Toxicology
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HAYASHI Koichi
The Institute of Environmental Toxicology
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ISHIMINE Sayaka
The Institute of Environmental Toxicology
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武田 真記夫
The Institute of Environmental Toxicology
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Takeda Makio
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Kosaka T
Inst. Environmental Toxicology Tokyo Jpn
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Kojima Sayuri
残留農薬研究所
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Tajima Yukari
The Institute Of Environmental Toxicology
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Mitsumori K
The Institute Of Environmental Toxicology:agrotox Inc.
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Tanaka Naoki
Laboratory Of Animal Management And Testing Chemistry Division Institute Of Environmental Toxicology
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Yoshida Toshihiko
Toxicology Division Institute Of Environmental Toxicology
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Takahashi Kazuaki
Institute Of Environmental Toxicology:(present Address)nippon Veterinary & Zootechnical College
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Takahashi N
The Institute Of Environmental Toxicology
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