THIRTEEN-WEEK SUBACUTE TOXICITY STUDY OF 4-BROMOPHENYL CHLOROMETHYL SULFONE (BCS) IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Four groups of 12 Wistar SPF rats of both sexes were fed diets containing 4-bromophenyl chloromethyl sulfone (BCS) at the levels of 0,20, 100 or 500 ppm for 13 weeks to evaluate the subacute toxicity. Males and females in the 500 ppm group showed increases in plasma protein and calcium and a decreased A/G ratio. The values of plasma total cholesterol and uric acid increased in this female group. In addition, significant increases in both absolute and relative weights were seen in the liver, thyroid and adrenal of this group of both sexes, together with the increased kidney weight in males. All males and females in the 500 ppm group had centrilobular hepatocellular swelling of the liver consisting of proliferation of the smooth endoplasmic reticulum. Males of this group also showed increased incidences of hyalin droplet degeneration of the proximal tubular epithelium and focal tubular atrophy of the kidney. The maximum no-effect level of BCS was determined to be 100 ppm (males: 6.25 mg/kg/day, females: 6.80 mg/kg/day).
- 日本トキシコロジー学会の論文
- 1985-11-25
著者
-
Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
-
Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
-
Kosaka Tadashi
The Institute of Environmental Toxicology
-
Mitsumori Kunitoshi
杏林製薬研究センター
-
MIYAOKA Teiji
Institute of Accelerator Analysis Ltd.
-
Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
-
SHIRASU Yasuhiko
Toxicology Division, Institute of Environmental Toxicology
-
MITSUMORI Kunitoshi
Institute of Environmental Toxicology
-
TAKAHASHI Kazuaki
Institute of Environmental Toxicology
-
SHIRASU Yasuhiko
Institute of Environmental Toxicology
-
Miyaoka Teiji
Institute Of Environmental Toxicology
-
Miyaoka Teiji
Institute Of Accelerator Analysis (iaa) Ltd.
-
Kosaka T
Toxicology Division Institute Of Environmental Toxicology
-
Kosaka Tadashi
Institute Of Environmental Toxicology
-
MAITA Keizo
Institute of Environmental Toxicology
-
Shirasu Y
Inst. Environmental Toxicology Ibaraki Jpn
-
Kosaka T
Inst. Environmental Toxicology Tokyo Jpn
-
Shirasu Yasuhiko
Toxicology Division Institute Of Environmental Toxicology
-
Mitsumori K
The Institute Of Environmental Toxicology:agrotox Inc.
-
Takahashi Kazuaki
Institute Of Environmental Toxicology:(present Address)nippon Veterinary & Zootechnical College
関連論文
- The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice
- Low dose effects of dichlorodiphenyltrichloroethane (DDT) on gene transcription and DNA methylation in the hypothalamus of young male rats : implication of hormesis-like effects
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Lack of Modifying Effects of Combined Treatment of t-butylhydroquinone and Sodium Nitrite on Forestomach Carcinogenesis in rasH2 Mice Initiated with N-ethyl-N-nitrosourea
- Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
- Tumorigenic Susceptibility of Catechol on the Gastric Mucosa in rasH2 Mice
- Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Promoting Effects of Ethinylestradiol but not Atrazine on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in ICR Mice
- Modifying Effects of 2,6-Dimethylaniline on Nasal Carcinogenesis in RasH2 Mice Initiated with 4-Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Crosstalk between PTEN/Akt2 and TGFβ signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model
- A Case Report of a Cerebellar Neuroblastoma in a p53 Null Mutation Mouse(Pathology)
- Suppressive effect of Siraitia grosvenorii extract on dicyclanil-promoted hepatocellular proliferative lesions in male mice
- In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens
- Modifying effect of Siraitia grosvenori extract on piperonyl butoxide-promoted hepatocarcinogenesis in rats
- Concurrent administration of ascorbic acid enhances liver tumor-promoting activity of kojic acid in rats
- Reactive Oxygen Species Are Possibly Involved in the Mechanism of Flumequine-Induced Hepatocarcinogenesis in Mice
- Molecular Analysis on the Possible Mechanism of β-Naphthoflavone-Induced Hepatocarcinogenesis in Rats
- Molecular Pathological Analysis of Apoptosis Induced in Testicular Germ Cells after a Single Administration of Mono-(2-ethylhexyl) phthalate to F344 Rats
- The expression of Ras-related molecules in DMBA-induced forestomach tumors in rasH2 mice(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- In vitro genotoxic potential and liver initiation activity of ciprofloxacin(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Mechanistic study on hepatocarcinogenesis induced by dicyclanil in mice : possible involvement of oxidative stress(Proceedings of the 32nd Annual Meeting)
- Induction of Hepatocellular Proliferative Lesions in CBA Mice by a 26-week Dietary Administration of Kojic Acid
- Absence of DNA Damage in Comet Assay and Liver Initiation Activity of Cinnamaldehyde
- O-16 Analysis of gene expression profiles of forestomach tumors in rasH2 mice initiated with N-ethyl-N-nitrosourea(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st
- Testicular Toxicity of Thiamphenicol in Sprague-Dawley Rats
- マイクロドーズの^C標識化合物の静脈内投与と Accelerator Mass Spectrometry 分析を用いたイヌ経口バイオアベイラビリティの算出
- Analysis of Gene Expression Profile on Uterine Tumorigenesis Initiated with N-ethyl-N-nitrosourea and Inhibited by Ethinylestradiol in rasH2 Mice
- THIRTEEN-WEEK REPEATED DOSE TOXICITY OF RICE BRAN GLYCOSPHINGOLIPID IN WISTAR HANNOVER (GALAS) RATS
- THIRTEEN-WEEK REPEATED DOSE TOXICITY STUDY OF WORMWOOD (ARTEMISIA ABSINTHIUM) EXTRACT IN RATS
- Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
- Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
- Possible enhancing effects of atrazine on growth of 7, 12-dimethylbenz(a) anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats
- O-13 Genotoxic potential in vitro and liver initiation activity of norfloxacin(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- O-12 Molecular pathological analyses on hepatocarcinogenesis induced by dicyclanil in mouse two-stage liver carcinogenesis model(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- MULTIPLICITY OF SPONTANEOUS LUNG TUMORS IN CD-1 MICE
- SPONTANEOUS TUMORS IN F344/DuCrj RATS FROM 12 CONTROL GROUPS OF CHRONIC AND ONCOGENICITY STUDIES
- 24-MONTH CHRONIC TOXICITY STUDY WITH GUAZATINE IN MICE
- 24-MONTH CHRONIC TOXICITY STUDY WITH GUAZATINE IN RATS
- RENAL TUMOR INDUCED BY METHYLMERCURY CHLORIDE IN ICR MICE
- SUBACUTE TOXICITY STUDIES WITH ZNSO_4 IN RATS AND MICE (The 6th Meeting for the Study of Toxic Effect)
- THIRTY-MONTH CHRONIC TOXICITY STUDIES WITH METHYL MERCURY CHLORIDE IN RATS (The 5th Meeting for the Study of Toxic Effect)
- Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver
- THIRTY-MONTH CHRONIC TOXICITY STUDIES WITH ZINC ETHYLENE BISDITHIOCARBAMATE (ZINEB) IN RATS (The 6th Meeting for the Study of Toxic Effect)
- TWENTY-FOUR-MONTH CHRONIC TOXICITY STUDIES WITH DICHLORODIISOPROPYLETHER (DCIP) IN RATS (The Fourth Meeting for the Study of Toxic Effect)
- TWENTY-FOUR-MONTH CHRONIC TOXICITY STUDIES WITH DICHLORODIISOPROPYLETHER (DCIP) IN MICE (The Fourth Meeting for the Study of Toxic Effect)
- 214. CHRONIC TOXICITY STUDIES IN RATS WITH METHYL MERCURY CHLORIDE (The Third Meeting for the Study of Toxic Effect)
- ABSENCE OF IN VIVO GENOTOXICITY AND LIVER INITIATION ACTIVITY OF DICYCLANIL
- 6例のF344ラットの耳介に発生した無色素性黒色腫〔英文〕
- THIRTEEN-WEEK SUBACUTE TOXICITY STUDY OF 4-BROMOPHENYL CHLOROMETHYL SULFONE (BCS) IN RATS
- SPONTANEOUS RADICULONEUROPATHY IN AGING RATS
- TWENTY FOUR-MONTH CHRONIC TOXICITY STUDY WITH BIS (DIMETHYLTHIOCARBAMOYL) DISULFIDE (THIRAM) IN BEAGLES
- DELAYED NEUROTOXICITY STUDIES IN JAPANESE QUAIL (The 6th Meeting for the Study of Toxic Effect)
- The Influence of Pre- and Post-natal Exposure to Methoxychlor on the Immune System and Renal Function of Sprague-Dawley Rats
- Age-Related Hematological Changes in Normal F344 Rats: during the Neonatal Period
- Point Mutations of the c-H-ras Gene in Spontaneous Pulmonary Tumors of Transgenic Mice Carrying the Human c-H-ras Gene
- Immunohistochemical demonstration of ornithine decarboxylase (ODC) expression in altered liver cell foci of rats treated with peroxisome proliferators.
- Molecular mechanisms of prostate enlargement induced with perinatal exposure of MXC in rats(Proceedings of the 32nd Annual Meeting)
- Alterations in the Developing Immune System of the Rat after Perinatal Exposure to Methoxychlor
- B25 HEPATOTOXICITY OF TOCP IN RATS
- EFFECTS OF CONTINUOUS ALCOHOL INGESTION ON LOCOMOTOR ACTIVITY AND EATING BEHAVIOR
- EFFECTS OF ALCOHOL ON SUBACUTE TOXICITY OF PESTICIDES
- RETARDATION OF EPIPHYSEAL CLOSURE OF THE TIBIA AND FEMUR IN RATS FOLLOWING THE CHRONIC ORAL ADMINISTRATION OF ZIRAM
- EFFECTS OF QUERCETIN AND BUTYLATED HYDROXYTOLUENE ON HAMSTERS EXPOSED TO TOBACCO SMOKE
- QUANTITATIVE EVALUATION OF THE BIOLOGICAL RESPONSES IN SYRIAN GOLDEN HAMSTERS EXPOSED TO CIGARETTE SMOKE AND THE EFFECT OF VITAMIN C ON SMOKE INHALATION TOXICITY
- TWENTY FOUR-MONTH CHRONIC TOXICITY STUDY WITH BIS (DIMETHYLTHIOCARBAMOYL) DISULFIDE (THIRAM) IN RATS
- THE EFFECT OF TESTOSTERONE PROPIONATE SUPPLEMENT ON TESTICULAR TOXICITY WITH THIAMPHENICOL IN MALE SPRAGUE-DAWLEY RATS
- Time-Course Change of Testicular Toxicity with Thiamphenicol in Male Sprague-Dawley Rats
- O11-08 Apoptosis of Thymic Lymphocytes in Immature Rats by Postnatal Methoxychlor Exposure.
- Morphological Variations in Trnasplanted Tumors Developed by Inoculation of Spontaneous Mesothelioma Cell Lines Derived from F344 Rats
- 2B-14 Carbamate insecticides selectively disrupt contextual fear memory in rats.
- A SAFETY STUDY ON RAT'S EYE AFTER 13-WEEK ORAL ADMINISTRATION WITH FENITROTHION
- MECHANISM OF NEMATICIDE : 1,3-DICHLOROPROPENE (DCP)-INDUCED HEPATOTOXICITY
- RELATIONSHIP BETWEEN TOXICITY AND CADMIUM ACCUMULATION IN RATS GIVEN LOW AMOUNTS OF CADMIUM CHLORIDE OR CADMIUM-POLLUTED RICE FOR 22 MONTHS
- CADMIUM ACCUMULATION IN RATS TREATED ORALLY WITH CADMIUM CHLORIDE FOR 8 MONTHS
- 21C-11-1 A study on mechanisms of the enhanced thyroidal tumorigenesis in rats by large amounts of vitamin A simultaneously given with thiourea : Effects on thyroidal hormone syntheses.
- Prevention of Stroke by a Japanese Traditional Medicine, Shichimotsu-koka-to, in Stroke-Prone Spontaneously Hypertensive Rats-a Histopathological Study
- Preventive Effects of Shinchimotsu-koka-to on Renal Lesions in Stroke-Prone Spontaneously Hypertensive Rats
- A basic research of regional variation of cholinesterase activity in the rat brain(Nervous system, Proceedings of the 32nd Annual Meeting)
- POSSIBLE MECHANISM ON ENHANCED CARCINOGENESIS OF GENOTOXIC CARCINOGENS AND UNSOLVED MECHANISMS ON LESSER CARCINOGENIC SUSCEPTIBILITY TO SOME CARCINOGENS IN RASH2 MICE
- COMPARISON OF WHOLE BODY EXPOSURE VERSUS SNOUT ONLY EXPOSURE IN INHALATION TOXICITY
- Accelerator mass spectrometry analysis of background ^C-concentrations in human blood : aiming at reference data for further microdosing studies
- MECHANISM OF POTENTIATION OF 2-sec-BUTYLPHENYL N-METHYLCARBAMATE TOXICITY BY FENTHION PRETREATMENT IN MICE
- Preparation and Characterization of Liposomal Microencapsulated Poly-γ-glutamic Acid for Prevention of Ca-Phosphate Precipitation under Intestinal Environment
- Intraperitoneal Insemination of the Guinea Pig with Synchronized Estrus Induced by Progesterone Implant
- Effects of long-term progesterone treatment on synchronized ovulation in guinea pigs
- Prevention of Stroke by a Japanese Traditional Medicine, Shichimotsu-koka-to, in Stroke-Prone Spontaneously Hypertensive Rats : a Histopathological Study
- Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action
- Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats
- Threshold dose of liver tumor promoting effect of β-naphthoflavone in rats
- Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action
- Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats
- Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats
- Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and β-naphthoflavone
- A Neuroendocrine Carcinoma of Undetermined Origin in a Dog
- A Mixed Apocrine Gland Tumor with Metastases to the Bone and Bone Marrow in a Miniature Poodle
- No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats
- Induction of hyperchromic microcytic anaemia by repeated oral administration of methotrexate in rats
- Transmission Electron and Immunoelectron Microscopic Studies on Microcystin-LR-Induced Hepatic Injuries in Mice